Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung

Authors

  • Shin Myung Kang MD,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
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  • Hyun Ju Kang,

    1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    2. Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
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  • Ju Hye Shin MS,

    1. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea
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  • Hoguen Kim MD,

    1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
    2. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea
    3. Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
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  • Dong Hwan Shin MD,

    1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
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  • Se Kyu Kim MD,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea
    3. Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    4. Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea
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  • Joo-Hang Kim MD,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Brain Korea 21 Projects for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    3. Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
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  • Kyung Young Chung MD,

    1. Department of Cardiovascular and Thoracic Surgery, Yonsei University College of Medicine, Seoul, Korea
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  • Sung Kyu Kim MD,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea
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  • Joon Chang MD

    Corresponding author
    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea
    • Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, 120-752, Korea
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    • Fax: (011) 82 2 393 6884


Abstract

BACKGROUND.

Adenosquamous carcinoma of the lung is composed of adenocarcinomatous and squamous cell carcinomatous components. The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. Attempts to investigate the EGFR mutation status in each component of adenosquamous carcinoma and to characterize the patients according to mutation status may help to understand the histogenesis of adenosquamous carcinoma.

METHODS.

The mutation status of EGFR kinase domain from exon 18 to 21 was investigated in 25 Korean patients with adenosquamous carcinoma by polymerase chain reaction–single strand conformation polymorphism using the tissues of each component from the adenosquamous carcinoma tumor. Clinicopathologic characteristics of the patients according to the status of EGFR mutations were compared.

RESULTS.

EGFR mutations were identified in 11 (44%) patients: 9 mutations were in exon 19, 1 in exon 20, and 1 in exon 21. EGFR mutations were significantly more frequent (P = .005) in women (n = 8, 80%) than men (n = 3, 20%). Never-smokers (n = 8, 62%) had EGFR mutations more commonly than smokers (n = 3, 25%; P = .111). Identical EGFR mutations in both components of adenosquamous carcinoma were confirmed by nucleotide sequencing.

CONCLUSIONS.

The frequency of EGFR mutation and clinicopathologic characteristics of the EGFR mutants in adenosquamous carcinoma are similar to those of Asian patients with adenocarcinomas. Identical EGFR mutations in both components suggest the possibility of monoclonality in the histogenesis of adenosquamous carcinoma. Cancer 2007;109:581–587. © 2006 American Cancer Society.

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