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Cystic pancreatic endocrine tumor
A variant commonly confused with cystic adenocarcinoma
Article first published online: 15 DEC 2006
Copyright © 2006 American Cancer Society
Volume 111, Issue 1, pages 47–53, 25 February 2007
How to Cite
Deshpande, V. and Lauwers, G. Y. (2007), Cystic pancreatic endocrine tumor. Cancer, 111: 47–53. doi: 10.1002/cncr.22422
- Issue published online: 15 FEB 2007
- Article first published online: 15 DEC 2006
- Manuscript Accepted: 25 SEP 2006
- Manuscript Revised: 17 SEP 2006
- Manuscript Received: 5 JUL 2006
- pancreatic endocrine tumor;
- cystic pancreatic neoplasm;
- fine-needle aspiration biopsy;
- endoscopic ultrasound;
Most cystic pancreatic neoplasms are currently evaluated by an endoscopic ultrasound-guided fine-needle aspiration biopsy (FNAB). In the authors' experience, FNAB of cystic pancreatic endocrine tumors (PETs) frequently causes diagnostic difficulties, partly because of unexpected overlapping features with cystic ductal adenocarcinomas.
The authors identified 5 histologically confirmed cystic PETs that were evaluated by FNAB and compared their cytomorphologic features to cystic ductal adenocarcinomas (n = 5) and solid PETs (n = 39) of the pancreas.
Cytologically, 2 of the aspirates of cystic PETs were devoid of tumor cells whereas the other 3 were variably cellular and composed of cohesive aggregates of monomorphic cellular elements with variably coarse chromatin. Tumor necrosis and nuclear membrane irregularities were not identified in cystic PETs. Alternatively, in contrast to PETs, cystic ductal adenocarcinomas were characterized by nuclear pleomorphism, nuclear membrane irregularities, and tumor necrosis.
Given the clinical implications, awareness of cystic PETs and their deceptive cytologic features would assist in distinguishing these lesions from cystic ductal adenocarcinomas. Cancer (Cancer Cytopathol) 2007 © 2006 American Cancer Society.