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Survival after hepatic resection in metastatic colorectal cancer
A population-based study
Article first published online: 19 JAN 2007
Copyright © 2007 American Cancer Society
Volume 109, Issue 4, pages 718–726, 15 February 2007
How to Cite
Cummings, L. C., Payes, J. D. and Cooper, G. S. (2007), Survival after hepatic resection in metastatic colorectal cancer. Cancer, 109: 718–726. doi: 10.1002/cncr.22448
- Issue published online: 2 FEB 2007
- Article first published online: 19 JAN 2007
- Manuscript Accepted: 13 NOV 2006
- Manuscript Revised: 8 NOV 2006
- Manuscript Received: 6 SEP 2006
- Postdoctoral Training Grant in Digestive Diseases. Grant Number: T32-DK61917
- American Cancer Society. Grant Number: RSGT-01-072-03-CPHPC
- Established Investigator in Cancer Prevention, Control and Population Science. Grant Number: (K05-CA90677)
- and End Results Program;
- colorectal neoplasm;
- neoplasm metastasis;
- surgical procedures, operative;
- outcome assessment
Hepatectomy is the standard of care for patients with colorectal cancer who have isolated hepatic metastases; however, the long-term survival benefits of hepatectomy in this population have not been characterized well outside of case series. For the current study, a population-based database was used to compare the survival of patients with liver metastases from colorectal cancer who did and did not undergo hepatectomy.
Patients aged ≥65 years with incident colorectal cancer who were diagnosed from 1991 to 2001 were identified from the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database. Liver metastasis diagnoses, colorectal resections, and hepatectomies were identified from hospital, outpatient, and physician-supplier claims. Patients who did not undergo colorectal resection were excluded. Five-year survival from the time of cancer diagnosis was determined by the Kaplan–Meier method. Cox proportional hazards models were used to evaluate survival.
Among 13,599 patients who were identified with incident colorectal cancer and liver metastases, 7673 patients (56.4%) presented with stage IV disease, and the remaining patients presented with earlier stage disease and developed subsequent metastases. Only 833 patients (6.1%) in the cohort underwent hepatic resection, and their 30-day mortality rate was 4.3%. The 5-year survival was 32.8% among patients who underwent hepatic resection, compared with 10.5% among patients who did not undergo hepatic resection (P < .0001), and better survival was observed in the subset of patients who presented initially with disease in stages I through III. In a Cox model, which was controlled for age, sex, race, comorbidities, and stage at presentation, lack of hepatic resection was associated with a 2.78-fold increased risk of death.
Although hepatectomy rates among patients with colorectal cancer were low, hepatic resection was associated with improved survival. Cancer 2007 © 2007 American Cancer Society.