SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Lynch TJ,Bell DW,Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004; 350: 21292139.
  • 2
    Paez JG,Janne PA,Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004; 304: 14971500.
  • 3
    Bell DW,Lynch TJ,Haserlat SM, et al. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol. 2005; 23: 80818092.
  • 4
    Shigematsu H,Lin L,Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005; 97: 339346.
  • 5
    Suzuki M,Shigematsu H,Iizasa T, et al. Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer. 2006; 106: 22002207.
  • 6
    Pao W,Miller V,Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004; 101: 1330613311.
  • 7
    Huang SF,Liu HP,Li LH, et al. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res. 2004; 10: 81958203.
  • 8
    Chou TY,Chiz CH,Li CY, et al. Mutations in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small-cell lung cancer. Clin Cancer Res. 2005; 11: 37503757.
  • 9
    Han SW,Kim TY,Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol. 2005; 23: 24932501.
  • 10
    Tam YSI,Chung LP,Suen WS, et al. Distinct epidermal growth factor receptor and KRAS mutation pattern in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res. 2006; 12: 16471653.
  • 11
    Cappuzzo F,Hirsh FR,Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst. 2005; 97: 643655.
  • 12
    Sonobe M,Manabe T,Wada H, et al. Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma. Br J Cancer. 2005; 93: 355363.
  • 13
    Marchetti A,Martela C,Felicioni L, et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol. 2005; 23: 857865.
  • 14
    Tokumo M,Toyooka S,Kiura K, et al. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clin Cancer Res. 2005; 11: 11671173.
  • 15
    Tomizawa Y,Iijima H,Sunaga N, et al. Clinicopathological significance of mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer. Clin Cancer Res. 2005; 11: 68166822.
  • 16
    Kosaka T,Yatabe Y,Endoh H,Kuwano H,Takahashi T,Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 2004; 64: 89198923.
  • 17
    Sugio K,Uramoto H,Oyama T, et al. Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking. Br J Cancer. 2006; 94: 896903.
  • 18
    Worm K,Dabbagh P,Schwechheimer K. Reverse transcriptase polymerase chain reaction as a reliable method to detect epidermal growth factor receptor exon 2–7 gene deletion in human glioblastomas. Hum Pathol. 1999; 30: 222226.
  • 19
    Garcia de Palazzo IE,Adams GP,Sundareshan P, et al. Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. Cancer Res. 1993; 53: 32173220.
  • 20
    Jungbluth AA,Stockert E,Su Huang HJ, et al. A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2003; 100: 639644.
  • 21
    Okamoto I,Kenyon LC,Emlet DR, et al. Expression of constitutively activated EGFRvIII in non-small cell lung cancer. Cancer Sci. 2003; 94: 5056.
  • 22
    Ji H,Zhao X,Yuza Y, et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2006; 103: 78177822.
  • 23
    Ohtsuka K,Ohnishi H,Furuyashiki G, et al. Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma. J Thorac Oncol. 2006; 1: 787795.
  • 24
    Travis WD,Colby TV,Corrin B,Shimosato Y,Brambilla E. Historical Typing of Lung and Pleural Tumors, World Health Organization International Histological Classification of Tumors. Berlin: Springer; 1999.
  • 25
    Sordella R,Bell DW,Haber DA,Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science. 2004; 305: 11631167.
  • 26
    Mellinghoff IK,Wang MY,Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005; 353: 20122024.
  • 27
    Ohnishi H,Ohtsuka K,Ooide A, et al. A simple and sensitive method for detecting major mutations within the tyrosine kinase domain of the epidermal growth factor receptor gene in non-small-cell lung carcinoma. Diagn Mol Pathol. 2006; 15: 101108.
  • 28
    Nakamura H,Kawasaki N,Taguchi M, et al. Survival impact of epidermal growth factor receptor overexpression in patients with non-small-cell lung cancer: a meta-analysis. Thorax. 2006; 61: 140145.
  • 29
    Nagai Y,Miyazawa H,Huqun, et al. Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp. Cancer Res. 2005; 65: 72767282.
  • 30
    Goya T,Asamura H,Yoshimura H, et al. Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese lung cancer registry study. Lung Cancer. 2005; 50: 227234.
  • 31
    Toyooka S,Yatabe Y,Tokumo M, et al. Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung. Int J Cancer. 2006; 118: 15881590.
  • 32
    Yang CH,Shih JY,Chen KC, et al. Survival outcome and predictors of gefitinib antitumor activity in East Asian chemonaive patients with advanced non small cell lung cancer. Cancer. 2006; 107: 18731882.