• 1
    Parkin DM,Bray F,Ferlay J,Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55: 74108.
  • 2
    Papadimitrakopoulou VA. Chemoprevention of head and neck cancer: an update. Curr Opin Oncol. 2002; 14: 318322.
  • 3
    Enzinger PC,Mayer RJ. Esophageal cancer. N Engl J Med. 2003; 349: 22412252.
  • 4
    Zeka A,Gore R,Kriebel D. Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis. Cancer Causes Control. 2003; 14: 897906.
  • 5
    American Institute for Cancer Research, World Cancer Research Fund. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research; 1997.
  • 6
    Mayne ST,Lippman SM. Cancer prevention: diet and chemopreventive agents. Retinoids, carotenoids, and micronutrients. In: DeVitaVT, HellmanS, RosenbergSA, editors. Principles & Practice of Oncology,6th ed. Philadelphia: Lippincott Williams & Wilkins; 2001: 575590.
  • 7
    The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann Epidemiol. 1994; 4: 110.
  • 8
    The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994; 330: 10291035.
  • 9
    Korhonen P,Malila N,Pukkala E,Teppo L,Albanes D,Virtamo J. The Finnish Cancer Registry as follow-up source of a large trial cohort—accuracy and delay. Acta Oncol. 2002; 41: 381388.
  • 10
    Bears OH. Manual for Staging of Cancer, 4th ed.American Joint Committee on Cancer, American Cancer Society. Philadelphia: Lippincott; 1992.
  • 11
    Pietinen P,Hartman AM,Haapa E, et al. Reproducibility and validity of dietary assessment instruments. I. A self-administered food use questionnaire with a portion size picture booklet. Am J Epidemiol. 1988; 128: 655666.
  • 12
    Milne DB,Botnen J. Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography. Clin Chem. 1986; 32: 874876.
  • 13
    Willett W. Nutritional Epidemiology, 2nd ed. New York: Oxford University Press; 1998.
  • 14
    Blot WJ,Li JY,Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993; 85: 14831492.
  • 15
    Li JY,Taylor PR,Li B, et al. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J Natl Cancer Inst. 1993; 85: 14921498.
  • 16
    Mayne ST,Cartmel B,Baum M, et al. Randomized trial of supplemental beta-carotene to prevent second head and neck cancer. Cancer Res. 2001; 61: 14571463.
  • 17
    Toma S,Bonelli L,Sartoris A, et al. Beta-carotene supplementation in patients radically treated for stage I-II head and neck cancer: results of a randomized trial. Oncol Rep. 2003; 10: 18951901.
  • 18
    Bairati I,Meyer F,Gelinas M, et al. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst. 2005; 97: 481488.
  • 19
    Albanes D,Heinonen OP,Taylor PR, et al. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst. 1996; 88: 15601570.
  • 20
    McLarty JW,Holiday DB,Girard WM,Yanagihara RH,Kummet TD,Greenberg SD. Beta-carotene, vitamin A, and lung cancer chemoprevention: results of an intermediate endpoint study. Am J Clin Nutr. 1995; 62(6 Suppl): 1431S1438S.
  • 21
    International Agency for Research on Cancer. IARC Handbooks of Cancer Prevention. Carotenoids. Vol. 2. Chapel Hill, NC: Oxford University Press; 1998.
  • 22
    Liu C,Russell RM,Wang XD. Exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome P450 enzymes. J Nutr. 2003; 133: 173179.
  • 23
    Wang XD,Liu C,Bronson RT,Smith DE,Krinsky NI,Russell M. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst. 1999; 91: 6066.
  • 24
    Nomura AM,Ziegler RG,Stemmermann GN,Chyou PH,Craft NE. Serum micronutrients and upper aerodigestive tract cancer. Cancer Epidemiol Biomarkers Prev. 1997; 6: 407412.
  • 25
    Zheng W,Blot WJ,Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res. 1993; 53: 795798.
  • 26
    Abnet CC,Qiao YL,Dawsey SM, et al. Prospective study ofserum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Cancer Causes Control. 2003; 14: 645655.
  • 27
    Taylor PR,Qiao YL,Abnet CC, et al. Prospective study of serum vitamin E levels and esophageal and gastric cancers. J Natl Cancer Inst. 2003; 95: 14141416.
  • 28
    Knekt P,Aromaa A,Maatela J, et al. Serum micronutrients and risk of cancers of low incidence in Finland. Am J Epidemiol. 1991; 134: 356361.
  • 29
    Kasum CM,Jacobs DRJr,Nicodemus K,Folsom AR. Dietary risk factors for upper aerodigestive tract cancers. Int J Cancer. 2002; 99: 267272.
  • 30
    Eastwood MA. Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease? QJM. 1999; 92: 527530.
  • 31
    Lawlor DA,Davey Smith G,Kundu D,Bruckdorfer KR,Ebrahim S. Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence? Lancet. 2004; 363: 17241727.
  • 32
    Rock CL. Carotenoids: biology and treatment. Pharmacol Ther. 1997; 75: 185197.
  • 33
    Ricciarelli R,Zingg JM,Azzi A. Vitamin E: protective role of a Janus molecule. FASEB J. 2001; 15: 23142325.
  • 34
    Bowman BA,Russell RM. International Life Sciences Institute-Nutrition Foundation. Present Knowledge in Nutrition, 8th ed. Washington, DC: ILSI Press International Life Sciences Institute; 2001.