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Kaposi sarcoma of the musculoskeletal system
A review of 66 patients
Version of Record online: 30 JAN 2007
Copyright © 2007 American Cancer Society
Volume 109, Issue 6, pages 1040–1052, 15 March 2007
How to Cite
Caponetti, G., Dezube, B. J., Restrepo, C. S. and Pantanowitz, L. (2007), Kaposi sarcoma of the musculoskeletal system. Cancer, 109: 1040–1052. doi: 10.1002/cncr.22500
- Issue online: 7 MAR 2007
- Version of Record online: 30 JAN 2007
- Manuscript Accepted: 1 DEC 2006
- Manuscript Revised: 24 NOV 2006
- Manuscript Received: 16 OCT 2006
- Kaposi sarcoma;
Kaposi sarcoma (KS) of bone and skeletal muscle is unusual. In this report, the authors review 66 published patients with KS who had involvement of the musculoskeletal system reported from 1925 to 2006. In only 3 patients was acquired immunodeficiency syndrome (AIDS)-related KS identified within skeletal muscle. Osseous KS lesions were more frequent and occurred with African, classic, and AIDS-related KS and occurred rarely in transplantation-associated KS. Patients seldom were asymptomatic. They usually had bone pain with limited mobility or infrequently developed serious sequelae like spinal cord compression. Locally aggressive African and classic KS lesions typically involved the peripheral skeleton; whereas, in patients with AIDS, the axial (vertebrae, ribs, sternum, and pelvis) and/or maxillofacial bones more commonly were involved. Almost all patients had concomitant nonosseous KS lesions. Joint involvement was exceptional, and pathologic fractures were not observed. Computed tomography scans and magnetic resonance images were better at detecting osseous KS lesions, which frequently went undetected on plain x-ray films or bone scans. Pathologic diagnosis was important to exclude similar lesions like bacillary angiomatosis. Treatment options, including surgery and, in more recent patients, radiation and/or chemotherapy, had limited success. Cancer 2007 © 2007 American Cancer Society.