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Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer
Article first published online: 5 MAR 2007
Copyright © 2007 American Cancer Society
Volume 109, Issue 8, pages 1493–1498, 15 April 2007
How to Cite
Efstathiou, J. A., Chen, M.-H., Renshaw, A. A., Loffredo, M. J. and D'Amico, A. V. (2007), Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer. Cancer, 109: 1493–1498. doi: 10.1002/cncr.22564
Fax: (617) 632-2742.
- Issue published online: 4 APR 2007
- Article first published online: 5 MAR 2007
- Manuscript Accepted: 8 JAN 2007
- Manuscript Revised: 4 JAN 2007
- Manuscript Received: 8 DEC 2006
- prostate cancer;
- PSA failure;
- radiation therapy;
- hormonal therapy
Increasing body mass index (BMI) is associated with shorter time to prostate-specific antigen (PSA) failure after radical prostatectomy. Whether BMI is associated with time to PSA failure was investigated in men treated with androgen suppression therapy (AST) and radiation therapy (RT) for clinically localized prostate cancer.
The observational prospective cohort study consisted of 102 men with clinically localized prostate cancer who received 70 Gy RT with 6 months of AST on a single arm of a randomized trial between December 1995 and April 2001. Height and weight data were available at baseline for 99 (97%) of the men, from which BMI was calculated. Adjusting for age (continuous) and known prognostic factors including PSA level (continuous), Gleason score, and T-category, Cox regression analyses were performed to analyze whether BMI (continuous) was associated with time to PSA failure (PSA >1.0 ng/mL and increasing >0.2 ng/mL on 2 consecutive visits).
Median age and median BMI (interquartile range [IQR]) at baseline was 72 (69.1–74.7) years and 27.4 (24.8–30.7) kg/m,2 respectively. In addition to an increasing PSA level (P = .006) and Gleason 8–10 cancer (P = .024), after a median follow-up (IQR) of 6.9 (5.6–8.5) years, an increasing BMI was also significantly associated with a shorter time to PSA failure (adjusted hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.01–1.19; P = .026) after RT and AST.
After adjusting for known prognostic factors, baseline BMI is significantly associated with time to PSA failure after RT and AST for men with clinically localized prostate cancer. Further study is warranted to assess the impact of an increasing BMI after AST administration on PSA failure, prostate cancer-specific, and all-cause mortality. Cancer 2007. © 2007 American Cancer Society.