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Validation and comparison of contemporary prognostic models in primary myelofibrosis
Analysis based on 334 patients from a single institution
Article first published online: 3 APR 2007
Copyright © 2007 American Cancer Society
Volume 109, Issue 10, pages 2083–2088, 15 May 2007
How to Cite
Tefferi, A., Huang, J., Schwager, S., Li, C.-Y., Wu, W., Pardanani, A. and Mesa, R. A. (2007), Validation and comparison of contemporary prognostic models in primary myelofibrosis. Cancer, 109: 2083–2088. doi: 10.1002/cncr.22630
- Issue published online: 25 APR 2007
- Article first published online: 3 APR 2007
- Manuscript Revised: 11 JAN 2007
- Manuscript Accepted: 11 JAN 2007
- Manuscript Received: 27 DEC 2006
- primary myelofibrosis;
- prognostic scoring systems
Survival in primary myelofibrosis (PMF) is predicted by several prognostic scoring systems (PSSs); the most widely recognized is that of Dupriez. Two other PSSs, Cervantes and Mayo, were recently reported as being more useful in younger patients. The current study compares these 3 PSSs among all age groups.
The Mayo Clinic PMF database was queried to identify a consecutive series of patients in whom pretreatment bone marrow and complete blood count (CBC), obtained within 6 months of diagnosis, were available for review.
Among 334 study patients (median age, 57 years), median survival was 70 months. Multivariable analysis of all 6 adverse prognostic factors utilized in the aforementioned PSSs (ie, hemoglobin <10 g/dL, leukocyte count <4 or >30 × 109/L, constitutional symptoms, circulating blasts ≥1%, platelet count <100 × 109/L, absolute monocyte count ≥1 × 109/L) identified all but platelet count as being significant. The Mayo PSS, which is based on the 4 CBC-derived parameters (ie, hemoglobin, platelet, leukocyte, and monocyte counts), displayed a better hazard ratio profile compared with the other 2 PSSs in identifying long-lived patients as well as delineating intermediate-risk disease category. The latter effect was even more pronounced in patients younger than age 60 years.
The Mayo PSS for survival in PMF is an objective CBC-derived prognostic model that might be superior in its performance over that of either the Dupriez and Cervantes PSSs. Cancer 2007. © 2007 American Cancer Society.