• 1
    Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985; 66: 848858.
  • 2
    Delsol G, Al Saati T, Gatter C, et al. Coexpression of epithelial membrane antigen (EMA), Ki-1 and interleukin-2 receptor by anaplastic large cell lymphomas: diagnostic value in so-called malignant histiocytosis. Am J Pathol. 1988; 130: 5970.
  • 3
    Egeler RM, Schmitz L, Sonneveld P, Mannival C, Nesbit ME. Malignant histiocytosis: a reassessment of cases formerly classified as histiocytic neoplasms and review of the literature. Med Pediatr Oncol. 1995; 25: 17.
  • 4
    Stein H, Foss HD, Durkop H, et al. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 2000; 96: 36813695.
  • 5
    JaffeSE, HarrisS NL, SteinH, WardimanJW, editors. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. In: World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2001.
  • 6
    Rimokh R, Magaud JP, Berger F, et al. A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma (‘Ki-1 lymphoma’). Br J Haematol. 1989; 71: 3136.
  • 7
    Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma [letter]. Science. 1994; 263: 12811284.
  • 8
    Wright D, McKeever P, Carter R. Childhood non-Hodgkin lymphomas in the United Kingdom: findings from the UK Children's Cancer Study Group. J Clin Pathol. 1997; 50: 128134.
  • 9
    Gudgin E, Rashbass J, Pulford KJ, Erber WN. Primary and isolated anaplastic large cell lymphoma of the bone marrow. Leuk Lymphoma. 2005; 46: 461463.
  • 10
    Bhagwati NS, Oiseth SJ, Abebe LS, Wiernik PH. Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity. Ann Hematol. 2004; 83: 247250. Epub 2003 Dec 5.
  • 11
    Wong KF, Chan JK, Ng CS, Chu YC, Lam PW, Yuen HL. Anaplastic large cell Ki-1 lymphoma involving bone marrow: marrow findings and association with reactive hemophagocytosis. Am J Hematol. 1991; 37: 112119.
  • 12
    Invernizzi R, Paulli M, Rosso R, et al. Reactive hemophagocytosis in Ki-l positive large cell lymphoma: a case study. Haematologica. 1989; 74: 155159.
  • 13
    Trapani JA, Smyth MJ. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol. 2002; 2: 735747.
  • 14
    Lowin B, Peitsch MC, Tschopp J. Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. Curr Top Microbiol Immunol. 1995; 198: 124.
  • 15
    Trambas CM, Griffiths GM. Delivering the kiss of death. Nat Immunol. 2003; 4: 399403.
  • 16
    Uellner R, Zvelebil MJ, Hopkins J, et al. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. EMBO J. 1997; 16: 72877296.
  • 17
    Masson D, Peters PJ, Geuze HJ, Borst J, Tschopp J. Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH. Biochemistry. 1990; 29: 1122911235.
  • 18
    Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999; 286: 19571959.
  • 19
    Arico M, Janka G, Fischer A, et al. Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry.FHL Study Group of the Histiocyte Society. Leukemia. 1996; 10: 197203.
  • 20
    Burnham JM, Kreiger PA, Paessler M, Kersun LS, Cron RQ. Picture of the month: anaplastic large cell lymphoma with hemophagocytic lymphohistiocytosis. Arch Pediatr Adolesc Med. 2006; 160: 11771179.
  • 21
    Falini B, Pileri S, De Solas I, et al. Peripheral T-cell lymphoma associated with hemophagocytic syndrome. Blood. 1990; 75: 434444.
  • 22
    Arico M. Peripheral T-cell lymphoma associated with hemophagocytic syndrome and hemophagocytic lymphohistiocytosis of children: do they share something? Blood. 1990; 76: 21632164.
  • 23
    Clementi R, Locatelli F, Dupre L, et al. A proportion of patients with lymphoma may harbor mutations of the perforin gene. Blood. 2005; 105: 44244428. Epub 2005 Feb 22.
  • 24
    Clementi R, Chiocchetti A, Cappellano G, et al. Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function. Blood. 2006; 108: 30793084.
  • 25
    Benharroch D, Meguerian-Bedoyan Z, Lamant L, et al. ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood. 1998; 91: 20762084.
  • 26
    Pulford K, Lamant L, Morris SW, et al. Detection of ALK and NPM-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK-1. Blood. 1997; 89: 13941404.
  • 27
    Goransdotter Ericson K, Fadeel B, Nilsson-Ardnor S, et al. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis. Am J Hum Genet. 2001; 68: 590597. Epub 2001 Feb 6.
  • 28
    Molleran Lee S, Villanueva J, Sumegi J, et al. Characterisation of diverse PRF1 mutations leading to decreased natural 29. killer cell activity in North American families with haemophagocytic lymphohistiocytosis. J Med Genet. 2004; 41: 137144.
  • 29
    Feldmann J, Le Deist F, Ouachee-Chardin M, et al. Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis. Br J Haematol. 2002; 117: 965972.
  • 30
    Busiello R, Adriani M, Locatelli F, et al. Atypical features of familial hemophagocytic lymphohistiocytosis. Blood. 2004; 103: 46104612. Epub 2004 Jan 22.
  • 31
    Zur Stadt U, Beutel K, Kolberg S, et al. Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A. Hum Mutat. 2006; 27: 6268.
  • 32
    Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006; 6: 715727.
  • 33
    Corthay A, Skovseth DK, Lundin KU, et al. Primary antitumor immune response mediated by CD4+ T cells. Immunity. 2005; 22: 371783.
  • 34
    Street SE, Hayakawa Y, Zhan Y, et al. Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells. J Exp Med. 2004; 199: 879884. Epub 2004 Mar 8.
  • 35
    Zur Stadt U, Beutel K, Weber B, Kabisch H, Schneppenheim R, Janka G. A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype. Blood. 2004; 104: 1909; author reply 1910.
  • 36
    Voskoboinik I, Thia MC, Trapani JA. A functional analysis of the putative polymorphisms A91V and N252S, and 22 missense perforin mutations associated with hemophagocytic lymphohistiocytosis. Blood. 2005; 105: 47004706. Epub 2005 Mar 8.
  • 37
    Trambas C, Gallo F, Pende D, et al. A single amino acid change, A91V, lead to conformational changes which can impair processing to the active form of perforin. Blood. 2005; 106: 932937.