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Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: A case-control study
Version of Record online: 9 MAY 2007
Copyright © 2007 American Cancer Society
Volume 109, Issue 12, pages 2547–2556, 15 June 2007
How to Cite
Hassan, M. M., Abbruzzese, J. L., Bondy, M. L., Wolff, R. A., Vauthey, J.-N., Pisters, P. W., Evans, D. B., Khan, R., Lenzi, R., Jiao, L. and Li, D. (2007), Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: A case-control study. Cancer, 109: 2547–2556. doi: 10.1002/cncr.22724
- Issue online: 4 JUN 2007
- Version of Record online: 9 MAY 2007
- Manuscript Accepted: 20 FEB 2007
- Manuscript Received: 27 DEC 2006
- National Institutes of Health RO1. Grant Number: CA098380 (to D.L.)
- Specialized Program in Research Excellence P20. Grant Number: CA101936 (to J.L.A.)
- National Institute of Environmental Health Science. Grant Number: ES07784
- Lockton Research Funds (to D.L.)
- passive smoking;
- tobacco product;
- pancreatic cancer;
- case-control study
The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear.
In this case-control study, the authors collected information on passive smoking and the use of noncigarette tobacco products in 808 patients with pancreatic adenocarcinoma and 808 healthy controls by personal interview. Multivariable logistic regression was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (95% CI).
The results confirmed the previously reported association between active smoking and increased risk for pancreatic cancer. The AOR was 1.7 (95% CI, 1.4–2.2) for regular smokers, 1.8 (95% CI, 1.4–2.4) for long-term smokers, and 3.1 (95% CI, 2.2–4.3) for former smokers. Although passive smoking showed a nonsignificantly elevated risk for pancreatic cancer in the entire study population (AOR, 1.3; 95% CI, 0.9–1.7), the association was present among ever smokers (AOR, 1.7; 95% CI, 1.03–2.6) but was absent among never smokers (AOR, 1.1; 95% CI, 0.8–1.6). Neither intensity nor duration of passive smoking modified the risk of pancreatic cancer among never smokers. The use of chewing tobacco, snuff, and pipes showed no significant risk elevation for pancreatic cancer after controlling for the confounding effects of demographics and other known risk factors. The use of cigars in never smokers showed a borderline significant increase of risk for pancreatic cancer (AOR, 2.2; 95% CI, 1.0–4.7; P = .05).
The current observations did not support a role for passive smoking or the use of noncigarette tobacco products in the etiology of pancreatic cancer. The association between cigar use and the risk of pancreatic cancer needs to be confirmed in other study populations. Cancer 2007. © 2007 American Cancer Society.