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Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions †
Article first published online: 20 JUN 2007
Copyright © 2007 American Cancer Society
Volume 110, Issue 3, pages 590–598, 1 August 2007
How to Cite
Jones, L. W., Peddle, C. J., Eves, N. D., Haykowsky, M. J., Courneya, K. S., Mackey, J. R., Joy, A. A., Kumar, V., Winton, T. W. and Reiman, T. (2007), Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions . Cancer, 110: 590–598. doi: 10.1002/cncr.22830
Presented in part at the 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, Georgia, June 2–6, 2006.
- Issue published online: 18 JUL 2007
- Article first published online: 20 JUN 2007
- Manuscript Accepted: 15 MAR 2007
- Manuscript Revised: 13 MAR 2007
- Manuscript Received: 11 JAN 2007
- Alberta Cancer Board, Canada
- exercise training;
- lung cancer;
- cardiorespiratory fitness
To determine the effects of preoperative exercise training on cardiorespiratory fitness in patients undergoing thoracic surgery for malignant lung lesions.
Using a single-group design, 25 patients with suspected operable lung cancer were provided with structured exercise training until surgical resection. Exercise training consisted of 5 endurance cycle ergometry sessions per week at intensities varying from 60% to 100% of baseline peak oxygen consumption (VO2peak). Participants underwent cardiopulmonary exercise testing, 6-minute walk (6MW), and pulmonary function testing at baseline, immediately before, and 30 days after surgical resection.
Five patients were deemed ineligible before surgical resection and were removed from the analysis. Of the remaining 20 patients follow-up assessments were obtained for 18 (90%) before resection and 13 (65%) patients postresection. The overall adherence rate was 72%. Intention-to-treat analysis indicated that mean VO2peak increased by 2.4 mL · kg−1 · min−1(95% confidence interval [CI], 1.0–3.8; P = .002) and 6MW distance increased 40m (95% CI, 16–64; P = .003) baseline to presurgery. Per protocol analyses indicated that patients who attended ≥80% of prescribed sessions increased VO2peak and 6MWD by 3.3 mL·kg−1·min−1 (95% CI, 1.1–5.4; P = .006) and 49 meters (95% CI, 12–85; P = .013), respectively. Exploratory analyses indicated that presurgical exercise capacity decreased postsurgery, but did not decrease beyond baseline values.
Preoperative exercise training is a beneficial intervention to improve cardiorespiratory fitness in patients undergoing pulmonary resection. This benefit may have important implications for surgical outcome and postsurgical recovery in this population. Larger randomized controlled trials are warranted. Cancer 2007. © 2007 American Cancer Society.