• 1
    Nuovo GJ,Darfler MM,Impraim CC,Bromley SE. Occurrence of multiple types of human papillomavirus in genital tract lesions. Analysis by in situ hybridization and the polymerase chain reaction. Am J Pathol. 1991; 138: 5358.
  • 2
    Bosch FX,Manos MM,Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995; 87: 796802.
  • 3
    Walboomers JM,Jacobs MV,Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999; 189: 1219.
  • 4
    Munoz N,Bosch FX,de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003; 348: 518527.
  • 5
    Melnikow J,Nuovo J,Paliescheskey M,Stewart GK,Howell L,Green W. Detection of high-grade cervical dysplasia: impact of age and Bethesda system terminology. Diagn Cytopathol. 1997; 17: 321325.
  • 6
    Solomon D,Schiffman M,Tarone R. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst. 2001; 93: 293299.
  • 7
    Khan MJ,Castle PE,Lorincz AT, et al. The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. JNatl Cancer Inst. 2005; 97: 10721079.
  • 8
    Cooper K,Herrington CS,Stickland JE,Evans MF,McGee JO. Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridisation. J Clin Pathol. 1991; 44: 990996.
  • 9
    Berumen J,Unger ER,Casas L,Figueroa P. Amplification of human papillomavirus types 16 and 18 in invasive cervical cancer. Hum Pathol. 1995; 26: 676681.
  • 10
    Kristiansen E,Jenkins A,Holm R. Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix. J Clin Pathol. 1994; 47: 253256.
  • 11
    Peitsaro P,Johansson B,Syrjanen S. Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol. 2002; 40: 886891.
  • 12
    Crum CP. Contemporary theories of cervical carcinogenesis: the virus, the host, and the stem cell. Mod Pathol. 2000; 13: 243251.
  • 13
    von Knebel Doeberitz M. New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer. 2002; 38: 22292242.
  • 14
    Zehbe I,Rylander E,Strand A,Wilander E. Use of Probemix and OmniProbe biotinylated cDNA probes for detecting HPV infection in biopsy specimens from the genital tract. JClin Pathol. 1993; 46: 437440.
  • 15
    Zehbe I,Hacker GW,Su H,Hauser-Kronberger C,Hainfeld JF,Tubbs R. Sensitive in situ hybridization with catalyzed reporter deposition, streptavidin-nanogold, and silver acetate autometallography: detection of single-copy human papillomavirus. Am J Pathol. 1997; 150: 15531561.
  • 16
    Evans MF,Aliesky HA,Cooper K. Optimization of biotinyl-tyramide-based in situ hybridization for sensitive background-free applications on formalin-fixed, paraffin-embedded tissue specimens. BMC Clin Pathol. 2003; 3: 2.
  • 17
    Wiedorn KH,Kuhl H,Galle J,Caselitz J,Vollmer E. Comparison of in-situ hybridization, direct and indirect in-situ PCR as well as tyramide signal amplification for the detection of HPV. Histochem Cell Biol. 1999; 111: 8995.
  • 18
    Speel EJ,Hopman AH,Komminoth P. Amplification methods to increase the sensitivity of in situ hybridization: play card(s). J Histochem Cytochem. 1999; 47: 281288.
  • 19
    Speel EJ,Komminoth P. CARD in situ hybridization: sights and signals. Endocr Pathol. 1999; 10: 193198.
  • 20
    Cooper K,Grayson W. Interpretation of the signal patterns produced by NISH in cervical neoplasia harbouring HPV. J Pathol. 1997; 183: 126.
  • 21
    Gravitt PE,Burk RD,Lorincz A, et al. A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation. Cancer Epidemiol Biomarkers Prev. 2003; 12: 477484.
  • 22
    Meissner JD. Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines. J Gen Virol. 1999; 80(Pt 7): 17251733.
  • 23
    Hesselink AT,van den Brule AJ,Brink AA, et al. Comparison of hybrid capture 2 with in situ hybridization for the detection of high-risk human papillomavirus in liquid-based cervical samples. Cancer (Cancer Cytopathol). 2004; 102: 1118.
  • 24
    Schiller CL,Nickolov AG,Kaul KL, et al. High-risk human papillomavirus detection: a split-sample comparison of hybrid capture and chromogenic in situ hybridization. Am J Clin Pathol. 2004; 121: 537545.
  • 25
    Hopman AH,Kamps MA,Smedts F, et al. HPV in situ hybridization: impact of different protocols on the detection of integrated HPV. Int J Cancer. 2005; 115: 419428.
  • 26
    Snijders PJ,van den Brule AJ,Meijer CJ. The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity. J Pathol. 2003; 201: 16.
  • 27
    Flores-Munguia R,Siegel E,Klimecki WT,Giuliano AR. Performance assessment of eight high-throughput PCR assays for viral load quantitation of oncogenic HPV types. J Mol Diagn. 2004; 6: 115124.
  • 28
    Hopman AH,Smedts F,Dignef W, et al. Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J Pathol. 2004; 202: 2333.
  • 29
    Wentzensen N,Vinokurova S,von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res. 2004; 64: 38783884.
  • 30
    Melsheimer P,Vinokurova S,Wentzensen N,Bastert G,von Knebel Doeberitz M. DNA aneuploidy and integration of human papillomavirus type 16 e6/e7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin Cancer Res. 2004; 10: 30593063.
  • 31
    Lizard G,Roignot P,Brunet-Lecomte P,Chardonnet Y. Morphological analysis of in situ hybridization signals in cervical intraepithelial neoplasia containing human papillomavirus type 16 or 18: relationship with histological grade and DNA content. Cytometry. 1998; 34: 180186.
  • 32
    Rihet S,Lorenzato M,Clavel C. Oncogenic human papillomaviruses and ploidy in cervical lesions. J Clin Pathol. 1996; 49: 892896.