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The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival†
Version of Record online: 4 SEP 2007
Copyright © 2007 American Cancer Society
Volume 110, Issue 8, pages 1738–1744, 15 October 2007
How to Cite
Kidd, E. A., Siegel, B. A., Dehdashti, F. and Grigsby, P. W. (2007), The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival. Cancer, 110: 1738–1744. doi: 10.1002/cncr.22974
See related editorial on pages 000-000, this issue.
- Issue online: 19 SEP 2007
- Version of Record online: 4 SEP 2007
- Manuscript Accepted: 17 APR 2007
- Manuscript Revised: 9 APR 2007
- Manuscript Received: 20 FEB 2007
- F-18 fluorodeoxyglucose-positron emission tomography;
- standardized uptake value
The objective of this study was to evaluate cervical tumor uptake of F-18 fluorodeoxyglucose (FDG) measured as the maximal standardized uptake value (SUVmax) by positron emission tomography (PET) and its association with treatment response and prognosis in patients with cervical cancer.
The study population consisted of 287 patients with stage IA2 through IVB cervical cancer who underwent pretreatment FDG-PET studies. SUVmax, tumor volume, and sites of lymph node metastasis were recorded. Therapy included surgery, chemoradiation, or palliation.
The mean SUVmax was 11.4 (range, 1–50.4). The mean tumor volume by stage was 42.1 cm3 for stage I tumors (using International Federation of Gynecology and Obstetrics [FIGO] staging criteria), 63.7 cm3 for stage II tumors, 129.2 cm3 for stage III tumors, and 166.2 cm3 for stage IV tumors. There was no correlation between tumor volume and SUVmax (correlation coefficient [R2] = 0.01). No significant difference in SUVmax was observed between squamous histology (n = 247 patients) and nonsquamous histology (n = 40 patients; P = .089). Higher SUVmax was associated with an increased risk of lymph node metastasis at diagnosis (P = .0009). A Cox proportional-hazards model for death from cervical cancer was used to evaluate tumor histology, lymph node metastasis, tumor volume, and SUVmax. The results indicated that SUVmax was the only significant independent factor (P = .0027). Three prognostic groups were established using SUVmax. The overall survival rates at 5 years were 95% for an SUVmax ≤ 5.2, 70% for an SUVmax > 5.2 and ≤13.3, and 44% for an SUVmax > 13.3 (P < .0001). Increasing SUVmax was associated with persistent abnormal FDG uptake in the cervix on 3-month FDG-PET studies in 238 patients who received curative chemoradiation (P = .04).
The SUVmax of the cervical tumor at diagnosis was a sensitive biomarker of treatment response and prognosis for patients with cervical cancer. Cancer 2007. © 2007 American Cancer Society.