• 1
    Wolff AC, Davidson NE. Primary systemic therapy in operable breast cancer. J Clin Oncol. 2000; 18: 15581569.
  • 2
    Clark J, Rosenman J, Cance W, Halle J, Graham M. Extending the indications for breast–conserving treatment to patients with locally advanced breast cancer. Int J Radiat Oncol Biol Phys. 1998; 42: 345350.
  • 3
    Danforth DNJr, Zujewski J, O'Shaughnessy J, et al. Selection of local therapy after neoadjuvant chemotherapy in patients with stage IIIA,B breast cancer. Ann Surg Oncol. 1998; 5: 150158.
  • 4
    Rouzier R, Pusztai L, Garbay JR, et al. Development and validation of nomograms for predicting residual tumor size and the probability of successful conservative surgery with neoadjuvant chemotherapy for breast cancer. Cancer. 2006; 107: 14591466.
  • 5
    Fisher B, Bryant J, Wolmark N, et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol. 1998; 16: 26722685.
  • 6
    Kuerer HM, Newman LA, Smith TL, et al. Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin–based neoadjuvant chemotherapy. J Clin Oncol. 1999; 17: 460469.
  • 7
    Rouzier R, Extra JM, Klijanienko J, et al. Incidence and prognostic significance of complete axillary downstaging after primary chemotherapy in breast cancer patients with T1 to T3 tumors and cytologically proven axillary metastatic lymph nodes. J Clin Oncol. 2002; 20: 13041310.
  • 8
    Bear HD, Anderson S, Brown A, et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B–27. J Clin Oncol. 2003; 21: 41654174.
  • 9
    Buzdar AU, Ibrahim NK, Francis D, et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2–positive operable breast cancer. J Clin Oncol. 2005; 23: 36763685.
  • 10
    Fisher B, Brown A, Mamounas E, et al. Effect of preoperative chemotherapy on local–regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B–18. J Clin Oncol. 1997; 15: 24832493.
  • 11
    Gonzalez–Angulo AM, Broglio K, Kau SW, et al. Women age ≤ 35 years with primary breast carcinoma: disease features at presentation. Cancer. 2005; 103: 24662472.
  • 12
    Green MC, Buzdar AU, Smith T, et al. Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks. J Clin Oncol. 2005; 23: 59835992.
  • 13
    Heys SD, Hutcheon AW, Sarkar TK, et al. Neoadjuvant docetaxel in breast cancer: 3–year survival results from the Aberdeen trial. Clin Breast Cancer. 2002; 3( suppl 2): S69S74.
  • 14
    Huang EH, Tucker SL, Strom EA, et al. Predictors of locoregional recurrence in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy, mastectomy, and radiotherapy. Int J Radiat Oncol Biol Phys. 2005; 62: 351357.
  • 15
    Kurosumi M. Significance of histopathological evaluation in primary therapy for breast cancer–recent trends in primary modality with pathological complete response (pCR) as endpoint. Breast Cancer. 2004; 11: 139147.
  • 16
    Amat S, Abrial C, Penault–Llorca F, et al. High prognostic significance of residual disease after neoadjuvant chemotherapy: a retrospective study in 710 patients with operable breast cancer. Breast Cancer Res Treat. 2005; 94: 255263.
  • 17
    Billgren AM, Rutqvist LE, Tani E, Wilking N, Fornander T, Skoog L. Proliferating fraction during neoadjuvant chemotherapy of primary breast cancer in relation to objective local response and relapse–free survival. Acta Oncol. 1999; 38: 597601.
  • 18
    Davis DW, Buchholz TA, Hess KR, Sahin AA, Valero V, McConkey DJ. Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response. Clin Cancer Res. 2003; 9: 955960.
  • 19
    Ganem G, Tubiana–Hulin M, Fumoleau P, et al. Phase II trial combining docetaxel and doxorubicin as neoadjuvant chemotherapy in patients with operable breast cancer. Ann Oncol. 2003; 14: 16231628.
  • 20
    Lippman ME, Allegra JC, Thompson EB, et al. The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N Engl J Med. 1978; 298: 12231228.
  • 21
    Mamounas EP. NSABP Protocol B–27. Preoperative doxorubicin plus cyclophosphamide followed by preoperative or postoperative docetaxel. Oncology (Williston Park). 1997; 11: 3740.
  • 22
    Nabholtz JM. Docetaxel (Taxotere) plus doxorubicin–based combinations: the evidence of activity in breast cancer. Semin Oncol. 1999; 26: 713.
  • 23
    Penault–Llorca F, Cayre A, Bouchet MF, et al. Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. Int J Oncol. 2003; 22: 13191325.
  • 24
    Stearns V, Singh B, Tsangaris T, et al. A prospective randomized pilot study to evaluate predictors of response in serial core biopsies to single agent neoadjuvant doxorubicin or paclitaxel for patients with locally advanced breast cancer. Clin Cancer Res. 2003; 9: 124133.
  • 25
    Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000; 406: 747752.
  • 26
    Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A. 2001; 98: 1086910874.
  • 27
    Sorlie T. Molecular portraits of breast cancer: tumour subtypes as distinct disease entities. Eur J Cancer. 2004; 40: 26672675.
  • 28
    Sorlie T, Wang Y, Xiao C, et al. Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms. BMC Genomics. 2006; 7: 127.
  • 29
    Bergamaschi A, Kim YH, Wang P, et al. Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene–expression subtypes of breast cancer. Genes Chromosomes Cancer. 2006; 45: 10331040.
  • 30
    Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A. 2003; 100: 84188423.
  • 31
    Chang HY, Nuyten DS, Sneddon JB, et al. Robustness, scalability, and integration of a wound–response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A. 2005; 102: 37383743.
  • 32
    Ambrogi F, Biganzoli E, Querzoli P, et al. Molecular subtyping of breast cancer from traditional tumor marker profiles using parallel clustering methods. Clin Cancer Res. 2006; 12: 781790.
  • 33
    Jacquemier J, Ginestier C, Rougemont J, et al. Protein expression profiling identifies subclasses of breast cancer and predicts prognosis. Cancer Res. 2005; 65: 767779.
  • 34
    Makretsov NA, Huntsman DG, Nielsen TO, et al. Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma. Clin Cancer Res. 2004; 10: 61436151.
  • 35
    Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal–like subtype of invasive breast carcinoma. Clin Cancer Res. 2004; 10: 53675374.
  • 36
    Abd El–Rehim DM, Ball G, Pinder SE, et al. High–throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer. 2005; 116: 340350.
  • 37
    GreeneFL, PageDL, FlemingID, editors. AJCC cancer staging manual. 6 ed. New York: Springer–Verlag; 2002.
  • 38
    World Health Organization. Tumors of the Breast. In: Classification of Tumors. Pathology and Genetics of Tumors of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003: 9112.
  • 39
    Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long–term follow–up. Histopathology. 1991; 19: 403410.
  • 40
    Fechner RE. Histologic variants of infiltrating lobular carcinoma of the breast. Hum Pathol. 1975; 6: 373378.
  • 41
    Martinez V, Azzopardi JG. Invasive lobular carcinoma of the breast: incidence and variants. Histopathology. 1979; 3: 467488.
  • 42
    Foote FW, Stewart FW. A histologic classification of carcinoma of the breast. Surgery. 1946; 19: 7499.
  • 43
    Middleton LP, Palacios DM, Bryant BR, Krebs P, Otis CN, Merino MJ. Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis. Am J Surg Pathol. 2000; 24: 16501656.
  • 44
    Eusebi V, Magalhaes F, Azzopardi JG. Pleomorphic lobular carcinoma of the breast: an aggressive tumor showing apocrine differentiation. Hum Pathol. 1992; 23: 655662.
  • 45
    Pu RT, Schott AF, Sturtz DE, Griffith KA, Kleer CG. Pathologic features of breast cancer associated with complete response to neoadjuvant chemotherapy: importance of tumor necrosis. Am J Surg Pathol. 2005; 29: 354358.
  • 46
    Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998; 11: 155168.
  • 47
    Abd El–Rehim DM, Pinder SE, Paish CE, et al. Expression and co–expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma. Br J Cancer. 2004; 91: 15321542.
  • 48
    Abd El–Rehim DM, Pinder SE, Paish CE, et al. Expression of luminal and basal cytokeratins in human breast carcinoma. J Pathol. 2004; 203: 661671.
  • 49
    Putti TC, Abd El–Rehim DM, Rakha EA, et al. Estrogen receptor–negative breast carcinomas: a review of morphology and immunophenotypical analysis. Mod Pathol. 2005; 18: 2635.
  • 50
    Rakha EA, Boyce RW, Abd El–Rehim D, et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005; 18: 12951304.
  • 51
    Rakha EA, Abd El–Rehim DA, Paish C, et al. Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer. 2006; 42: 31493156. Epub 2006 Oct 19.
  • 52
    Rakha EA, Putti TC, Abd El–Rehim DM, et al. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. J Pathol. 2006; 208: 495506.
  • 53
    Smith IC, Heys SD, Hutcheon AW, et al. Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel. J Clin Oncol. 2002; 20: 14561466.
  • 54
    Smith IE, Dowsett M, Ebbs SR, et al. Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double–blind randomized trial. J Clin Oncol. 2005; 23: 51085116.
  • 55
    Colleoni M, Viale G, Zahrieh D, et al. Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. Clin Cancer Res. 2004; 10: 66226628.
  • 56
    Zhang F, Yang Y, Smith T, et al. Correlation between HER–2 expression and response to neoadjuvant chemotherapy with 5–fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma. Cancer. 2003; 97: 17581765.
  • 57
    Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2–positive breast cancer. N Engl J Med. 2005; 353: 16731684.
  • 58
    Cocquyt VF, Blondeel PN, Depypere HT, et al. Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma. Eur J Surg Oncol. 2003; 29: 361367.
  • 59
    Cristofanilli M, Gonzalez–Angulo A, Sneige N, et al. Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes. J Clin Oncol. 2005; 23: 4148.
  • 60
    Mathieu MC, Rouzier R, Llombart–Cussac A, et al. The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile. Eur J Cancer 2004; 40: 342351.
  • 61
    Rouzier R, Mathieu MC, Sideris L, et al. Breast–conserving surgery after neoadjuvant anthracycline–based chemotherapy for large breast tumors. Cancer. 2004; 101: 918925.
  • 62
    Tubiana–Hulin M, Stevens D, Lasry S, et al. Response to neoadjuvant chemotherapy in lobular and ductal breast carcinomas: a retrospective study on 860 patients from one institution. Ann Oncol. 2006; 17: 12281233.