• 1
    Sonmezer M,Oktay K. Fertility preservation in female patients. Hum Reprod Update. 2004; 10: 251266.
  • 2
    Lutchman Singh K,Davies M,Chatterjee R. Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing. Hum Reprod Update. 2005; 11: 6989.
  • 3
    Morita Y,Perez GI,Paris F et al. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med. 2000; 10: 11091114.
  • 4
    Plowchalk DR,Mattison DR. Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide. Toxicol Appl Pharmacol. 1991; 107: 472481.
  • 5
    Oktay K. Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection? Hum Reprod. 2006; 21: 13451348.
  • 6
    Faddy MJ,Gosden RG. A model conforming the decline in follicle numbers to the age of menopause in women. Hum Reprod. 1996; 11: 14841486.
  • 7
    Oktay K,Oktem O,Reh A, et al. Measuring the impact of chemotherapy on fertility in women with breast cancer. JClin Oncol. 2006; 24: 40444046.
  • 8
    Scheffer GJ,Broekmans FJ,Looman CW, et al. The number of antral follicles in normal women with proven fertility is the best reflection of reproductive age. Hum. Reprod. 2003; 18: 700706.
  • 9
    Johnson J,Bagley J,Skaznik-Wikiel M, et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005; 122: 303315.
  • 10
    Johnson J,Canning J,Kaneko T, et al. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004; 428: 145150.
  • 11
    Oktay K,Karlikaya G,Akman O, et al. Interaction of extracellular matrix and activin-A in the initiation of follicle growth in the mouse ovary. Biol Reprod. 2000; 63: 457461.
  • 12
    Oktay K,Oktem O. A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve. Fertil Steril. 2006; 86( suppl 1): S95S96.
  • 13
    Meirow D,Lewis H,Nugent D, et al. Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool. Hum Reprod. 1999; 14: 19031907.
  • 14
    Cobleigh MA,Bines J,Harris D, et al. Amenorrhea following adjuvant chemotherapy for breast cancer. Proc Am Soc Clin Oncol. 1995; 14: A158.
  • 15
    Reh AE,Oktem O,Lostritto K, et al. Impact of breast cancer chemotherapy on ovarian reserve: a prospective analysis by menstrual history and ovarian reserve markers. Fertil Steril. 2006; 86( suppl 1): S97S98.
  • 16
    Bonadonna G,Santoro A,Viviani S, et al. Gonadal damage in Hodgkin's disease from cancer chemotherapy regimens. Arch Toxicol. 1984; 7: 140145.
  • 17
    Santoro A,Bonnadonna G,Valagussa P, et al. Long-term results of combined chemotherapy-radiotherapy approach in Hodgkin's disease: superiority of ABVD plus radiotherapy versus MOPP plus radiotherapy. J Clin Oncol. 1987; 5: 2737.
  • 18
    Lemez P,Urbanek V. Chemotherapy for acute myeloid leukemias with cytosine arabinoside, daunorubicin, etoposide, and mitoxantrone may cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. Neoplasma. 2005; 52: 398401.
  • 19
    Oktay K,Newton H,Mullan J, et al. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Hum Reprod. 1998; 13: 11331138.
  • 20
    Oktay K,Briggs D,Gosden RG. Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocrinol Metab. 1997; 82: 37483751.
  • 21
    Ryu BY,Orwig KE,Oatley JM, et al. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells. 2006; 24: 15051511.
  • 22
    Lee HJ,Selesniemi K,Niikura T, et al. Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. J Clin Oncol. 2007; 25: 31983204.
  • 23
    Schwartz GN,Warren MK,Rothwell SW, et al. Post-chemotherapy and cytokine pretreated marrow stromal cell layers suppress hematopoiesis from normal donor CD34+ cells. Bone Marrow Transplant. 1998; 22: 457468.