Study of radiolabeled indium-111 and yttrium-90 ibritumomab tiuxetan in primary central nervous system lymphoma

Authors

  • Fabio M. Iwamoto MD,

    1. Department of Neurology, Memorial Sloan- Kettering Cancer Center, New York, New York
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  • Jazmin Schwartz PhD,

    1. Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
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  • Neeta Pandit-Taskar MD,

    1. Department of Radiology (Nuclear Medicine), Memorial Sloan-Kettering Cancer Center, New York, New York
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  • Scott Peak MD,

    1. Department of Neurology, Memorial Sloan- Kettering Cancer Center, New York, New York
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  • Chaitanya R. Divgi MD,

    1. Department of Radiology (Nuclear Medicine), Memorial Sloan-Kettering Cancer Center, New York, New York
    Current affiliation:
    1. Department of Radiology, University of Pennsylvania, Philadelphia, PA
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  • Andrew D. Zelenetz MD,

    1. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York
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    • Lauren E. Abrey and Andrew D. Zelenetz received research funding from Biogen IDEC. Biogen-IDEC provided the drug and financial support.

  • John Humm PhD,

    1. Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
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  • Lauren E. Abrey MD

    Corresponding author
    1. Department of Neurology, Memorial Sloan- Kettering Cancer Center, New York, New York
    • Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021
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    • Lauren E. Abrey and Andrew D. Zelenetz received research funding from Biogen IDEC. Biogen-IDEC provided the drug and financial support.

    • Fax: (917) 432-2310;


Abstract

BACKGROUND.

Therapeutic options for refractory or recurrent primary central nervous system lymphoma (PCNSL) are limited. The blood–brain barrier makes many agents used in systemic lymphomas ineffective in CNS lymphomas. The objective of this study was to determine whether intravenous radioimmunotherapy using anti-CD20 antibody can be delivered to PCNSL.

METHODS.

This was a single-institution prospective study. Indium-111 ibritumomab tiuxetan was used for imaging and dosimetry. Yttrium-90 ibritumomab tiuxetan at doses of 0.3 to 0.4 mCi/kg were subsequently given for the treatment of recurrent or refractory PCNSL. 111In data were used to estimate radiation doses to lesions delivered by 90Y ibritumomab tiuxetan therapy.

RESULTS.

Six patients (4 men, 2 women) with a median age of 60 years and median Karnofsky performance status of 70 received both indium-111 and yttrium-90 ibritumomab tiuxetan. The median absorbed dose delivered to the CNS lymphoma was 701 cGy compared with 70 cGy to normal brain. The median progression-free and overall survival times were 6.8 weeks and 14.3 weeks, respectively.

CONCLUSIONS.

The results from this study suggest that it may be feasible to deliver radiolabeled monoclonal anti-CD20 antibodies as a component of therapy for PCNSL. Cancer 2007. © 2007 American Cancer Society.

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