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Emotional well-being does not predict survival in head and neck cancer patients†
A radiation therapy oncology group study
Article first published online: 22 OCT 2007
Copyright © 2007 American Cancer Society
Volume 110, Issue 11, pages 2568–2575, 1 December 2007
How to Cite
Coyne, J. C., Pajak, T. F., Harris, J., Konski, A., Movsas, B., Ang, K. and Watkins Bruner, D. (2007), Emotional well-being does not predict survival in head and neck cancer patients. Cancer, 110: 2568–2575. doi: 10.1002/cncr.23080
Presented at the Annual Meeting of the American Psychosomatic Society, Orlando, Florida, March 3–6, 2004.
- Issue published online: 19 NOV 2007
- Article first published online: 22 OCT 2007
- Manuscript Accepted: 7 SEP 2007
- Manuscript Revised: 23 JUN 2007
- Manuscript Received: 25 APR 2007
- head and neck;
- emotional well-being
The objective of the current study was to examine whether emotional well-being predicted survival in a large sample of patients with head and neck cancer who were participating in multicenter clinical trials.
Participants were enrolled in 2 Radiation Oncology Group (RTOG) clinical trials (RTOG 9003 and RTOG 9111) and completed a baseline measure of quality of life (the Functional Assessment of Cancer Therapy-General [FACT-G]), which included an Emotional Well-Being subscale. The outcome measure was overall survival. Main statistical analyses included overall survival rates, which were estimated by using the Kaplan-Meier method with univariate comparisons analyzed using the log-rank test. A multivariate Cox proportional hazards model was used to determine whether emotional well-being had prognostic impact on survival after accounting for tumor-related and sociodemographic variables. Additional exploratory analyses examined possible subgroup effects.
No statistically significant univariate or multivariate effects were observed for emotional well-being, and there were no effects limited to subgroups. These results stand in sharp contrast to the prognostic value of a variety of demographic and clinical variables.
The current results add to the weight of the evidence that emotional functioning is not an independent predictor of survival in cancer patients. The study had the advantage of a large number of deaths to be explained in a sample with the uniformity of treatment and quality of care that is required in clinical trials. Cancer 2007. © 2007 American Cancer Society.