1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Fax: (011) 31 71-5248115
1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
Original Article
You have full text access to this OnlineOpen article
The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
Article first published online: 15 NOV 2007
DOI: 10.1002/cncr.23160
Copyright © 2007 American Cancer Society
Additional Information
How to Cite
Kodach, L. L., Bleuming, S. A., Musler, A. R., Peppelenbosch, M. P., Hommes, D. W., van den Brink, G. R., van Noesel, C. J. M., Offerhaus, G. J. A. and Hardwick, J. C. H. (2008), The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. Cancer, 112: 300–306. doi: 10.1002/cncr.23160
Publication History
- Issue published online: 4 JAN 2008
- Article first published online: 15 NOV 2007
- Manuscript Accepted: 9 AUG 2007
- Manuscript Revised: 7 AUG 2007
- Manuscript Received: 28 MAR 2007
REFERENCES
- 1,,,,,. Cancer statistics, 2003. CA Cancer J Clin. 2003; 53: 5–26.Direct Link:
- 2,. A genetic model for colorectal tumorigenesis. Cell. 1990; 61: 759–767.
- 3,,. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst. 2000; 92: 1388–1402.
- 4,. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003; 425: 577–584.
- 5,,, et al. Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues. Cancer Res. 2000; 60: 2840–2844.
- 6,,, et al. Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells. Oncogene. 2004; 23: 7651–7659.
- 7,,, et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science. 1998; 280: 1086–1088.
- 8,,, et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet. 2001; 28: 184–187.
- 9,,, et al. Risk of colorectal cancer in juvenile polyposis. Gut. 2007; 56: 965–967.
- 10,,, et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science. 2004; 303: 1684–1686.
- 11,,, et al. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology. 2004; 126: 111–121.
- 12,,, et al. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci USA. 1995; 92: 7632–7636.
- 13,,, et al. Mad-related genes in the human. Nat Genet. 1996; 13: 347–349.
- 14,,, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996; 271: 350–353.
- 15,,, et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 1995; 268: 1336–1338.
- 16,,, et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet. 1996; 13: 343–346.
- 17,,, et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet. 2004; 41: 484–491.
- 18,,, et al. Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res. 1998; 58: 3101–3104.
- 19,,,,,. Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability. Cancer Genet Cytogenet. 2005; 157: 18–24.
- 20,,, et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med. 2001; 344: 1196–1206.
- 21,,. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001; 29: 117–129.