Fax: (011) 852 2645 0605.
Original Article
You have full text access to this OnlineOpen article
Increased inducible nitric oxide synthase in lung carcinoma of smokers
Article first published online: 15 NOV 2007
DOI: 10.1002/cncr.23166
Copyright © 2007 American Cancer Society
Additional Information
How to Cite
Chen, G. G., Lee, T. W., Xu, H., Yip, J. H. Y., Li, M., Mok, T. S. K. and Yim, A. P. C. (2008), Increased inducible nitric oxide synthase in lung carcinoma of smokers. Cancer, 112: 372–381. doi: 10.1002/cncr.23166
Publication History
- Issue published online: 4 JAN 2008
- Article first published online: 15 NOV 2007
- Manuscript Accepted: 8 AUG 2007
- Manuscript Revised: 30 MAY 2007
- Manuscript Received: 14 MAR 2007
Funded by
- Research Grants Council of the Hong Kong Special Administrative Region. Grant Number: Project Ref: CUHK 4390 of 03M
REFERENCES
- 1,. The Tobacco Atlas. Geneva: World Health Organization; 2002.
- 2. Molecular epidemiology of smoking and lung cancer. Oncogene. 2002; 21: 6870–6876.
- 3. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol. 2002; 3: 461–469.
- 4. Hong Kong tobacco deaths presage vast China epidemic. Bull WHO. 2001; 79: 999.
- 5,,,,,. Cancer statistics. CA Cancer J Clin. 2003; 53: 5–26.Direct Link:
- 6. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep. 2004; 24: 452–474.
- 7
- 8,,, et al. Abnormalities in nitric oxide and its derivatives in lung cancer. Am J Resp Crit Care Med. 2005; 172: 597–605.
- 9,,,,,. Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer. Bri J Cancer. 1998; 78: 534–541.
- 10,,, et al. Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma. Jpn J Cancer Res. 1998; 89: 696–702.
- 11,,, et al. Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Br J Cancer. 1998; 78: 233–239.
- 12,,, et al. Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res. 2000; 6: 4739–4744.
- 13,,,,. Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke. Thorax. 2001; 56: 456–461.
- 14,,,,,. Effects of cigarette smoke on nitric oxide synthase expression in the rat lung. Lab Invest. 1999; 79: 975–983.
- 15,,. Acute inhalation of cigarette smoke increases lower respiratory tract nitric oxide concentrations. Thorax. 1998; 53: 677–679.
- 16,. Role of nitric oxide in the induction of apoptosis by smokeless tobacco extract. Mol Cell Biochem. 1999; 200: 51–57.
- 17,,,,,. Nitric oxide formation in the oropharyngeal tract: possible influence of cigarette smoking. Nitric Oxide. 2004; 11: 247–255.
- 18,,, et al. Cigarette smoke decreases inducible nitric oxide synthase in lung epithelial cells. Expl Lung Res. 2003; 29: 17–28.
- 19,,,,,. Infection with respiratory syncytial virus and water-soluble components of cigarette smoke alter production of tumour necrosis factor alpha and nitric oxide by human blood monocytes. FEMS Immunol Med Microbiol. 1999; 24: 387–394.
- 20,,,,. Long-term smoking impairs platelet-derived nitric oxide release. Circulation. 1996; 94: 3109–3114.
- 21,,. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O2 or cigarette smoke. Am J Resp Cell Mol Biol. 2000; 23: 350–354.
- 22,,,,,. Plasma nitric oxide before and after smoking cessation with nicotine nasal spray. J Clin Pharmacol. 1998; 38: 22–27.
- 23,,,. Real-life environmental tobacco exposure does not affect exhaled nitric oxide levels in asthmatic children. J Asthma. 2005; 42: 113–118.
- 24,,,. Nitric oxide in cancer and chemoprevention. Free Radic Biol Med. 2003; 34: 955–968.
- 25,,, et al. Differential expression of inducible nitric oxide synthase and peroxisome proliferator-activated receptor gamma in non-small cell lung carcinoma. Eur J Cancer. 2003; 39: 1296–1301.
- 26,. Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res. 2001; 89: 224–236.
- 27
- 28,,,,. Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL. Anticancer Drugs. 2003; 14: 761–766.
- 29,. Nitric oxide as a modulator of apoptosis. Cancer Lett. 2005; 226: 1–15.
- 30,,, et al. High expression of nitric oxide synthases is a favorable prognostic sign in non-small cell lung carcinoma. APMIS. 2003; 111: 1137–1146.Direct Link:
- 31,,,. The role of nitric oxide on cigarette smoke-induced programmed cell death in the gastric mucosa. Scand J Gastroenterol. 2001; 36: 235–240.
- 32,,,,,. Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast Cancer Res Treatment. 2003; 79: 95–105.
- 33,,, et al. Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. J Biol Chem. 2004; 279: 7584–7590.
- 34. Nitric oxide suppression triggers apoptosis through the FKHRL1 (FOXO3A)/ROCK kinase pathway in human breast carcinoma cells. Cancer. 2003; 97: 1358–1363.Direct Link:
- 35,,, et al. Carbon monoxide and nitric oxide protect against tumor necrosis factor-alpha-induced apoptosis in osteoblasts: HO-1 is necessary to mediate the protection. Clin Chim Acta. 2006; 365: 270–278.
- 36,,,. Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. Int J Cancer. 2003; 106: 666–675.Direct Link:
- 37,,. Nitrosylation of cytochrome c during apoptosis. J Biol Chem. 2003; 278: 18265–18270.
- 38,,,,. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res. 1996; 24: 2236–2242.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)