Original Article

You have full text access to this OnlineOpen article

VEGF and VEGFR-1 are coexpressed by epithelial and stromal cells of renal cell carcinoma

  1. Jacqueline Rivet MD1,
  2. Samia Mourah MD, PhD2,
  3. Hideyuki Murata MD, PhD1,
  4. Nicolas Mounier MD, PhD1,
  5. Helena Pisonero1,
  6. Pierre Mongiat-Artus MD, PhD3,
  7. Pierre Teillac MD, PhD3,
  8. Fabien Calvo MD, PhD2,
  9. Anne Janin MD, PhD1,
  10. Christine Dosquet MD, PhD4,†,*

Article first published online: 26 NOV 2007

DOI: 10.1002/cncr.23186

Issue

Cancer

Cancer

Volume 112, Issue 2, pages 433–442, 15 January 2008

Additional Information

How to Cite

Rivet, J., Mourah, S., Murata, H., Mounier, N., Pisonero, H., Mongiat-Artus, P., Teillac, P., Calvo, F., Janin, A. and Dosquet, C. (2008), VEGF and VEGFR-1 are coexpressed by epithelial and stromal cells of renal cell carcinoma. Cancer, 112: 433–442. doi: 10.1002/cncr.23186

Author Information

  1. 1

    Laboratoire de Pathologie and U728, INSERM, Université Paris 7, Hôpital Saint-Louis, AP-HP, and Institut Universitaire d'Hématologie, Paris, France

  2. 2

    Laboratoire de Pharmacologie and U716, INSERM, Université Paris 7, Hôpital Saint-Louis, AP-HP, and Institut Universitaire d'Hématologie, Paris, France

  3. 3

    Service d'Urologie, Hôpital Saint-Louis, AP-HP, and Institut Universitaire d'Hématologie, Paris, France

  4. 4

    Unité de Thérapie cellulaire and U553, INSERM, Université Paris 7, Hôpital Saint-Louis, AP-HP, and Institut Universitaire d'Hématologie, Paris, France

  1. †

    Fax: (011) 33 1 42 49 95 65.

*Unité de Thérapie Cellulaire, Hôpital St.-Louis, 1 avenue Claude Vellefaux 75475 Paris cedex 10 France

Publication History

  1. Issue published online: 4 JAN 2008
  2. Article first published online: 26 NOV 2007
  3. Manuscript Accepted: 9 AUG 2007
  4. Manuscript Revised: 3 AUG 2007
  5. Manuscript Received: 23 APR 2007

Funded by

  • University Paris 7
  • Inserm
  • GIP/HMR
  • PHRC

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (2363K)

REFERENCES

  • 1
    Carmeliet P,Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407: 249–257.
  • 2
    Ferrara N,Gerber HP,LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9: 669–676.
  • 3
    Rini BI,Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol. 2005; 23: 1028–1043.
  • 4
    Nathan P,Chao D,Brock C, et al. The place of VEGF inhibition in the current management of renal cell carcinoma. Br J Cancer. 2006; 94: 1217–1220.
  • 5
    Millauer B,Wizigmann-Voos S,Schnurch H, et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993; 72: 835–846.
  • 6
    Poltorak Z,Cohen T,Sivan R, et al. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem. 1997; 272: 7151–7158.
  • 7
    Leung DW,Cachianes G,Kuang WJ,Goeddel DV,Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246: 1306–1309.
  • 8
    Keyt BA,Nguyen HV,Berleau LT, et al. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem. 1996; 271: 5638–5646.
  • 9
    Ohta Y,Endo Y,Tanaka M, et al. Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Clin Cancer Res. 1996; 2: 1411–1416.
  • 10
    Tokunaga T,Oshika Y,Abe Y, et al. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer. 1998; 77: 998–1002.
  • 11
    Olsson AK,Dimberg A,Kreuger J,Claesson-Welsh L. VEGF receptor signalling—in control of vascular function. Nat Rev Mol Cell Biol. 2006; 7: 359–371.
  • 12
    Tlsty TD,Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 2001; 11: 54–59.
  • 13
    Fukumura D,Xavier R,Sugiura T, et al. Tumor induction of VEGF promoter activity in stromal cells. Cell. 1998; 94: 715–725.
  • 14
    Lopez-Beltran A,Scarpelli M,Montironi R,Kirkali Z. 2004 WHO classification of the renal tumors of the adults. Eur Urol. 2006; 49: 798–805.
  • 15
    Javidan J,Stricker HJ,Tamboli P, et al. Prognostic significance of the 1997 TNM classification of renal cell carcinoma. J Urol. 1999; 162: 1277–1281.
  • 16
    Fuhrman SA,Lasky LC,Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982; 6: 655–663.
  • 17
    Brown LF,Berse B,Jackman RW, et al. Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol. 1993; 143: 1255–1262.
  • 18
    Nicol D,Hii SI,Walsh M,Teh B, et al. Vascular endothelial growth factor expression is increased in renal cell carcinoma. J Urol. 1997; 157: 1482–1486.
  • 19
    Paradis V,Lagha NB,Zeimoura L, et al. Expression of vascular endothelial growth factor in renal cell carcinomas. Virchows Arch. 2000; 436: 351–356.
  • 20
    Slaton JW,Inoue K,Perrotte P, et al. Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol. 2001; 158: 735–743.
  • 21
    Ljungberg B,Jacobsen J,Haggstrom-Rudolfssson S,Rasmuson T,Lindh G,Grankvist K. Tumour vascular endothelial growth factor (VEGF) mRNA in relation to serum VEGF protein levels and tumour progression in human renal cell carcinoma. Urol Res. 2003; 31: 335–340.
  • 22
    Gasparini G,Toi M,Gion M, et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst. 1997; 89: 139–147.
  • 23
    Linderholm B,Grankvist K,Wilking N,Johansson M,Tavelin B,Henriksson R. Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol. 2000; 18: 1423–1431.
  • 24
    Takahashi A,Sasaki H,Kim SJ, et al. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res. 1994; 54: 4233–4237.
  • 25
    Tomisawa M,Tokunaga T,Oshika Y, et al. Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma. Eur J Cancer. 1999; 35: 133–137.
  • 26
    Hemmerlein B,Kugler A,Ozisik R,Ringert RH,Radzun HJ,Thelen P. Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas. Virchows Arch. 2001; 439: 645–652.
  • 27
    Tsuchiya N,Sato K,Akao T, et al. Quantitative analysis of gene expressions of vascular endothelial growth factor-related factors and their receptors in renal cell carcinoma. Tohoku J Exp Med. 2001; 195: 101–113.
  • 28
    Wu Y,Hooper AT,Zhong Z, et al. The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma. Int J Cancer. 2006; 2: 2.
  • 29
    Herold-Mende C,Steiner HH,Andl T, et al. Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab Invest. 1999; 79: 1573–1582.
  • 30
    Yoshimura I,Mizuguchi Y,Miyajima A,Asano T,Tadakuma T,Hayakawa M. Suppression of lung metastasis of renal cell carcinoma by the intramuscular gene transfer of a soluble form of vascular endothelial growth factor receptor I. J Urol. 2004; 171: 2467–2470.
  • 31
    Kaplan RN,Riba RD,Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005; 438: 820–827.
  • 32
    Lesslie DP,Summy JM,Parikh NU, et al. Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. Br J Cancer. 2006; 94: 1710–1717.
  • 33
    Dias S,Hattori K,Zhu Z, et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest. 2000; 106: 511–521.
  • 34
    Hayashibara T,Yamada Y,Miyanishi T, et al. Vascular endothelial growth factor and cellular chemotaxis: a possible autocrine pathway in adult T-cell leukemia cell invasion. Clin Cancer Res. 2001; 7: 2719–2726.
View Full Article (HTML) Get PDF (2363K)