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Neck treatment of patients with early stage oral tongue cancer

Comparison between observation, supraomohyoid dissection, and extended dissection

  1. Shiang-Fu Huang MD1,2,
  2. Chung-Jan Kang MD1,2,
  3. Chen-Yu Lin MD2,3,
  4. Kang-Hsing Fan MD2,3,
  5. Tzu-Chen Yen MD, PhD2,4,
  6. Hung-Ming Wang MD2,5,
  7. I-How Chen MD1,2,
  8. Chun-Ta Liao MD1,2,
  9. Ann-Joy Cheng PhD2,6,
  10. Joseph Tung-Chieh Chang MD, MHA2,3,7,†,*

Article first published online: 1 FEB 2008

DOI: 10.1002/cncr.23278

Issue

Cancer

Cancer

Volume 112, Issue 5, pages 1066–1075, March 2008

Additional Information

How to Cite

Huang, S.-F., Kang, C.-J., Lin, C.-Y., Fan, K.-H., Yen, T.-C., Wang, H.-M., Chen, I.-H., Liao, C.-T., Cheng, A.-J. and Chang, J. T.-C. (2008), Neck treatment of patients with early stage oral tongue cancer. Cancer, 112: 1066–1075. doi: 10.1002/cncr.23278

Author Information

  1. 1

    Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  2. 2

    Head and Neck Oncology Group, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  3. 3

    Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  4. 4

    Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  5. 5

    Department of Internal Medicine, Division of Hematology/Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  6. 6

    Department of Medical Biotechnology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

  7. 7

    Chang Gung Institute of Technology, Taoyuan, Taiwan

  1. †

    Fax: (011) 886-3-3280797

*Department of Radiation Oncology, Chang Gung Memorial Hospital at No. Five Fu-Shin Street, Kwei-Shan, Taoyuan, Taiwan

  1. †

    Fax: (011) 886-3-3280797

Publication History

  1. Issue published online: 19 FEB 2008
  2. Article first published online: 1 FEB 2008
  3. Manuscript Accepted: 25 SEP 2007
  4. Manuscript Revised: 3 SEP 2007
  5. Manuscript Received: 7 JUN 2007

Funded by

  • National Science Council of Taiwan. Grant Number: NSC-96-2628B -182A -098-MY3

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Keywords:

  • early stage;
  • tongue cancer;
  • neck dissection;
  • supraomohyoid neck dissection;
  • CT scan;
  • MRI

Abstract

BACKGROUND.

The role of elective and therapeutic selective neck dissection in patients with early stage cancer of the oral tongue remains controversial. The purpose was to investigate the role of neck treatment in the management of this condition.

METHODS.

A total of 380 patients with cT1-2N0 oral tongue cancer were retrospectively reviewed. Patients were staged by means of computed tomography (CT) or magnetic resonance imaging (MRI) scans. A total of 324 patients received elective neck dissection (END), whereas 56 participants received observation (OBS). In all, 287 patients received supraomohyoid neck dissection (SOND), whereas 37 patients received modified radical neck dissection (MRND). Overall survival (OS) and neck control rates (NCR) were investigated according to the treatment modality.

RESULTS.

In the END group the occult metastasis (OM) rates in cervical lymph nodes were 5.2% for cT1 lesions and 14.6% for cT2 lesion (P = .005). The 5-year OS (P = .029) and NCR rates (P = .001) were significantly better in the END group compared with the OBS group. Patients who received MRND had a better 5-year NCR compared with SOND, albeit not significantly (91.4% vs 85.3%, P = .415). Multivariate analysis showed that END and stage were independent predictors of both NCR and OS.

CONCLUSIONS.

END should be performed routinely in patients with early-stage oral tongue cancer, even in the presence of negative neck by CT scans and MRI. Cancer 2008. © 2008 American Cancer Society

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