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Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot
Version of Record online: 19 FEB 2008
Copyright © 2008 American Cancer Society
Volume 112, Issue 7, pages 1625–1631, 1 April 2008
How to Cite
Scotté, F., Banu, E., Medioni, J., Levy, E., Ebenezer, C., Marsan, S., Banu, A., Tourani, J. M., Andrieu, J.-M. and Oudard, S. (2008), Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer, 112: 1625–1631. doi: 10.1002/cncr.23333
- Issue online: 19 MAR 2008
- Version of Record online: 19 FEB 2008
- Manuscript Accepted: 23 OCT 2007
- Manuscript Revised: 11 OCT 2007
- Manuscript Received: 7 SEP 2007
- cold therapy;
- nail changes;
- cutaneous toxicity;
Onycholysis occurs in approximately 30% of patients treated with docetaxel. The efficacy and safety of an Elasto-Gel frozen sock (FS) was investigated for the prevention of docetaxel-induced nail and skin toxicity of the feet.
Patients receiving docetaxel at a dose of 70 to 100 mg/m2 every 3 weeks were eligible for this matched case-control study. Each patient wore an FS for 90 minutes on the right foot. The unprotected left foot acted as control. Nail and skin toxicities were assessed using National Cancer Institute Common Toxicity Criteria (version 3) and compared using a 2-sample Wilcoxon matched-pairs rank test adjusted for tied values.
Fifty consecutive patients were included between April 2005 and January 2007. Nail toxicity was significantly lower in the FS-protected foot compared with the control foot (grade 0: 100% versus 79%; and grade 1 and 2: 0% versus 21%, respectively) (P = .002). Skin toxicity was grade 0: 98% versus 94%; and grade 1 and 2: 2% versus 6% in the FS-protected and the control feet, respectively. The median times until toxicity occurrence were not found to differ significantly between the groups. One patient experienced discomfort because of cold intolerance.
Cold therapy using FS significantly reduced the incidence of docetaxel-induced foot nail toxicity, as previously demonstrated using frozen gloves for the hands. Cancer 2008. © 2008 American Cancer Society.