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Cardiovascular risk in long-term survivors of testicular cancer
Article first published online: 13 MAR 2008
Copyright © 2008 American Cancer Society
Volume 112, Issue 9, pages 1949–1953, 1 May 2008
How to Cite
Vaughn, D. J., Palmer, S. C., Carver, J. R., Jacobs, L. A. and Mohler, E. R. (2008), Cardiovascular risk in long-term survivors of testicular cancer. Cancer, 112: 1949–1953. doi: 10.1002/cncr.23389
Fax: (215) 662-7804
- Issue published online: 21 APR 2008
- Article first published online: 13 MAR 2008
- Manuscript Accepted: 10 DEC 2007
- Manuscript Revised: 29 NOV 2007
- Manuscript Received: 20 SEP 2007
- National Cancer Institute Grant. Grant Number: 1R21CA097355-01
- Pennsylvania Department of Health
- testicular cancer;
- endothelial dysfunction
Long-term survivors of testicular cancer (TC) who received cisplatin-based chemotherapy have an increased risk of cardiovascular disease. A cross-sectional study was performed to objectively assess cardiovascular risk, subclinical atherosclerosis, and endothelial function in long-term survivors of TC.
Long-term survivors of TC underwent evaluation including determination of body mass index (BMI), Framingham relative risk (RR), brachial artery flow-mediated dilatation (FMD), carotid artery intima-media thickness (IMT), soluble intercellular adhesion molecule-1 (sICAM-1), high sensitivity C-reactive protein (hs-CRP), and flow cytometric analysis of peripheral blood for levels of endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs). TC survivors who received chemotherapy were compared with a chemotherapy naive cohort.
Twenty-four patients received cisplatin-based chemotherapy (CBCT) and 15 were chemotherapy-naive (CN). The CBCT cohort demonstrated more impairment of brachial artery FMD than the CN group (5.6% vs 8.8%; P = .05). The mean sICAM was also found to be higher in the CBCT cohort compared with the CN group (P = .04). No significant differences between the groups were noted with regard to BMI, Framingham RR, carotid IMT, or hs-CRP. In a subset of patients, TC survivors who received chemotherapy had a significantly increased level of CECs compared with CN patients (P = .04). No significant difference in EPC levels was detected.
Long-term survivors of TC who received chemotherapy demonstrate objective evidence of endothelial injury and dysfunction, a potential mechanism for increased cardiovascular risk. Cancer 2008. © 2008 American Cancer Society.