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Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial†
The Yale Exercise and Survivorship Study
Version of Record online: 21 APR 2008
Copyright © 2008 American Cancer Society
Supplement: Cancer Survivorship: Embracing the Future
Volume 112, Issue Supplement 11, pages 2593–2606, 1 June 2008
How to Cite
Irwin, M. L., Cadmus, L., Alvarez-Reeves, M., O'Neil, M., Mierzejewski, E., Latka, R., Yu, H., DiPietro, L., Jones, B., Knobf, M. T., Chung, G. G. and Mayne, S. T. (2008), Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial. Cancer, 112: 2593–2606. doi: 10.1002/cncr.23446
This supplement was sponsored by the American Cancer Society's Behavioral Research Center and the National Cancer Institute's Office of Cancer Survivorship.
- Issue online: 19 MAY 2008
- Version of Record online: 21 APR 2008
- Manuscript Accepted: 2 JAN 2008
- Manuscript Received: 5 DEC 2007
- American Cancer Society. Grant Number: MRSG-04-006-01-CPPB
- Susan G. Komen Breast Cancer Foundation. Grant Number: BCTR0201916
- General Clinical Research Center grant from the National Center of Research Resources
- National Institutes of Health. Grant Number: M01-RR00125
- Yale University School of Medicine
- physical activity;
- body fat;
Given observational findings that physical activity reduces breast cancer risk, improves survival, and improves quality of life in breast cancer survivors, a need has been identified for randomized controlled trials that testthe efficacy of exercise on biological mechanisms associated with breast cancer survival. The primary aims of the Yale Exercise and Survivorship Study were to 1) determine the feasibility of recruiting breast cancer survivors into a randomized controlled trial of the effects of exercise on biological markers and/or mechanisms associated with survival, 2) compare the effectiveness of various recruitment strategies on accrual rates and baseline characteristics, and 3) report adherence to the exercise trial.
Seventy-five postmenopausal breast cancer survivors self-referred into the trial or were recruited through the Connecticut Tumor Registry and randomly assigned to an exercise (n = 37) or usual-care (n = 38) group. The exercise group participated in 150 min/wk of supervised gym-based and home-based aerobic exercise for 6 months. The usual-care group was instructed to maintain current physical activity level.
A total of 75 women (an accrual rate of 9.5%) were randomized to the trial. Rates of accrual were higher for women who self-referred into the study (19.8%) compared with women recruited via the cancer registry (7.6%); however, demographic, physiologic, and prognostic characteristics did not differ between the 2 recruitment strategies. On average, exercisers increased moderate- intensity to vigorous-intensity aerobic exercise by 129 minutes per week compared with 44 minutes per week among usual-care participants (P < .001). Women in the exercise-intervention group increased their average pedometer steps by 1621 steps per day compared with a decrease of 60 steps per day among women in the usual-care group (P < .01).
Findings from this study will provide useful information for investigators who are conducting exercise trials in cancer populations, clinicians who are treating women diagnosed with breast cancer, and exercise professionals who are developing community-based exercise programs for cancer survivors. Cancer 2008. © 2008 American Cancer Society.