Fax: (011) 33 3 80 66 82 51
Original Article
You have full text access to this OnlineOpen article
Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer
A population-based study
Article first published online: 2 JUN 2008
DOI: 10.1002/cncr.23629
Copyright © 2008 American Cancer Society
Additional Information
How to Cite
Bouvier, A.-M., Jooste, V., Bonnetain, F., Cottet, V., Bizollon, M.-H., Bernard, M.-P. and Faivre, J. (2008), Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer. Cancer, 113: 879–886. doi: 10.1002/cncr.23629
Publication History
- Issue published online: 1 AUG 2008
- Article first published online: 2 JUN 2008
- Manuscript Accepted: 13 MAR 2008
- Manuscript Revised: 25 FEB 2008
- Manuscript Received: 8 JAN 2008
Funded by
- The Hospital Clinical Research Program (PHRC)
- Health French Ministry (2004)
- Regional Council of Bourgogne (2004)
REFERENCES
- 1,,, et al. Incidence of digestive cancers in France. Gastroenterol Clin Biol. 2004; 28: 877–881.
- 2,,, et al. The effect of treatment for colorectal cancer on long-term health-related quality of life. Ann Surg Oncol. 2001; 8: 44–49.
- 3,,, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990; 322: 352–358.
- 4,,, et al. Changes in the practice of adjuvant radiotherapy in resectable rectal cancer within a French well-defined population. Radiother Oncol. 2000; 57: 137–142.
- 5,,, et al. Chemotherapy for colon cancer in a well-defined French population: is it under- or over-prescribed? Aliment Pharmacol Ther. 2002; 16: 353–359.Direct Link:
- 6,,, et al. Use of adjuvant chemotherapy and radiation therapy for colorectal cancer in a population-based cohort. J Clin Oncol. 2003; 21: 1293–1300.
- 7,,, et al. Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: a population-based study. Cancer J. 2001; 7: 213–218.
- 8,,, et al. Trends in the management and survival of digestive tract cancers among patients aged over 80 years. Aliment Pharmacol Ther. 2005; 22: 233–241.Direct Link:
- 9,,, et al. EORTC QLQ-C30 Scoring Manual. 3rd ed. Brussels, Belgium: EORTC Study Group on Quality of Life; 2001.
- 10,,. Critical review of the international assessments of health-related quality of life. Qual Life Res. 1993; 2: 369–395.
- 11,,, et al. Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis. 1981; 34: 585–597.
- 12World Health Organization. International Classification of Diseases for Oncology. Geneva: World Health Organization; 1992.
- 13,. TNM staging atlas. Geneva: World Health Organization; 2007.
- 14,,, et al. Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic. J Clin Oncol. 1989; 7: 1447–1456.
- 15Conference de Consensus. Prevention, depistage et prise en charge des cancers du colon. Gastroenterol Clin Biol. 1998; 22: S275–S288.
- 16,,, et al. Use of adjuvant chemotherapy and radiation therapy for rectal cancer among the elderly: a population-based study. J Clin Oncol. 2002; 20: 2643–2650.
- 17,. Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial. Ann Surg. 1990; 211: 187–195.
- 18,,, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004; 351: 1731–1740.
- 19,,, et al. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol. 1998; 16: 139–144.
- 20
- 21,,. Pattern mixture models for longitudinal quality of life studies in advanced stage disease. Stat Med. 2003; 22: 795–809.Direct Link:
- 22,,, et al. Evaluation of quality of life in a clinical trial with nonrandom dropout: the effect of epoetin alfa in anemic cancer patients. Qual Life Res. 2003; 12: 1013–1027.
- 23,,, et al. Comparison of several model-based methods for analysing incomplete quality of life data in cancer clinical trials. Stat Med. 1998; 17: 781–796.Direct Link:
- 24,,. Quality of Life (QoL) in advanced colorectal cancer (ACC): a comparison of QoL during bolus plus infusion 5FU/Leucovorin (LV5FU2) with or without oxaliplatin [abstract]. Proc Am Soc Clin Oncol. 1999; 18: 234a.
- 25. Lessons learned from measuring health-related quality of life in oncology. J Clin Oncol. 1994; 12: 608–616.
- 26,,, et al. Adjuvant chemotherapy for colon carcinoma with positive lymph nodes: use and benefit in routine health care practice. Br J Cancer. 2001; 85: 1251–1257.
- 27,,, et al. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomic status, gender, and comorbidity. Ann Oncol. 2005; 16: 767–772.
- 28,. Cancer treatment and age: patient perspectives. J Natl Cancer Inst. 1993; 85: 1580–1584.
- 29,,, et al. Health quality of life and colorectal cancer. Cancer. 1992; 70( 5 suppl): 1450–1456.Direct Link:
- 30,,. Quality of life and independence in activities of daily living preoperatively and at follow-up in patients with colorectal cancer. Support Care Cancer. 1997; 5: 402–409.

1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470)