The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver tumors. However, no matter now astounding these past achievements may be, it is clear that the future holds even greater promise. Cancer 2008;113(7 suppl):1888–96. © 2008 American Cancer Society.