Brain tumor epidemiology: Consensus from the Brain Tumor Epidemiology Consortium

Authors

  • Melissa L. Bondy PhD,

    Corresponding author
    1. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
    • Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, TX 77030
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    • Fax: (713) 792-8478

  • Michael E. Scheurer PhD,

    1. Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas
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  • Beatrice Malmer MD,

    1. Department of Radiation Sciences and Oncology, Umea University, Umea, Sweden
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  • Jill S. Barnholtz-Sloan PhD,

    1. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio
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  • Faith G. Davis PhD,

    1. Division of Epidemiology/Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois
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  • Dora Il'yasova PhD,

    1. Department of Community and Family Medicine, Duke Comprehensive Cancer Center, Duke University, Durham, North Carolina
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  • Carol Kruchko,

    1. Central Brain Tumor Registry of the United States, Hinsdale, Illinois
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  • Bridget J. McCarthy PhD,

    1. Division of Epidemiology/Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois
    2. Central Brain Tumor Registry of the United States, Hinsdale, Illinois
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  • Preetha Rajaraman PhD,

    1. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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  • Judith A. Schwartzbaum PhD,

    1. Division of Epidemiology, School of Public Health, Ohio State University, Columbus, Ohio
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  • Siegal Sadetzki MD, MPH,

    1. Cancer and Radiation Epidemiology Unit, Gernter Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
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  • Brigitte Schlehofer PhD,

    1. Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany
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  • Tarik Tihan MD,

    1. Department of Pathology, University of California, San Francisco, California
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  • Joseph L. Wiemels PhD,

    1. Department of Epidemiology and Biostatistics, University of California, San Francisco, California
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  • Margaret Wrensch PhD,

    1. Department of Neurological Surgery, University of California, San Francisco, California
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  • Patricia A. Buffler PhD,

    1. Division of Epidemiology, School of Public Health, University of California, Berkeley, California
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  • On behalf of the Brain Tumor Epidemiology Consortium

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    • Members of the Brain Tumor Epidemiology Consortium (in alphabetical order): Phyllis Adatto, MPH (M. D. Anderson Cancer Center), Jill Barnholtz-Sloan, PhD (Case Comprehensive Cancer Center), Fabienne Bauchet (Groupe de Neuro-Oncologie du Languedoc-Roussillon), Luc Bauchet, MD (Hopital Gui de Chauliac), Melissa Bondy, PhD (M. D. Anderson Cancer Center), Jennifer Brusstar (The Tug McGraw Foundation), Patricia Buffler, PhD (University of California, Berkeley), Mary Ann Butler, PhD (CDC/NIOSH), Elizabeth Cardis, PhD (IARC), Tania Carreon-Valencia, PhD (CDC/NIOSH), Jeffrey Chang, PhD (University of California, San Francisco), Anand Chokkalingam, PhD (University of California, Berkeley), Charles Cobbs, MD (CPMC Research Institute), Jimmy Efrid, PhD (University of Hawaii), Paul Graham Fisher, MD (Stanford University), James Gurney, PhD (University of Michigan), Trisha Hartge, PhD (NCI/NIH), Dora Il'yasova, PhD (Duke University Medical Center), Alice Kang (University of California, Berkeley), Carol Kruchko (Central Brain Tumor Registry of the United States), Amy Kyle, PhD (University of California, Berkeley), Rose Lai, MD (Columbia University), Sharon Lamb (National Brain Tumor Foundation), Ching Lau, MD, PhD (Baylor College of Medicine), Beatrice Malmer, MD (Umea University), Bridget McCarthy, PhD (University of Illinois at Chicago), Roberta McKean-Cowdin, PhD (University of Southern California), Eckart Meese, PhD (University of Saarland), Catherine Metayer, PhD (University of California, Berkeley), Dominique Michaud, SD (Imperial College London), Isis Mikhail, MD, DrPH (NCI/NIH), Lloyd Morgan (Central Brain Tumor Registry of the United States), Beth Mueller, PhD (Fred Hutchinson Cancer Research Center), Michael Murphy, PhD (University of Oxford), John Neuberger, DrPH (University of Kansas), Manuela Orjuela, MD (Columbia University), Harriet Patterson, MPH (National Brain Tumor Foundation), Susan Preston-Martin, PhD (University of Southern California), Preetha Rajaraman, PhD (NCI/NIH), Steve Rappaport, PhD (University of California, Berkeley), Avima Ruder, PhD (CDC/NIOSH), Siegal Sadetzki, MD (Gertner Institute), Michael Scheurer, PhD (BaylorCollege of Medicine), Brigitte Schlehofer, PhD (German Cancer Research Center), Joerg Schlehofer, MD (German Cancer Research Center), Judith Schwartzbaum, PhD (Ohio State University), Jenni Spezeski, MPH (National Brain Tumor Foundation), Tarik Tihan, MD (University of California, San Francisco), Rob Tufel, MPH (National Brain Tumor Foundation), Kevin Urayama, MPH (University of California, Berkeley), Joseph Wiemels, PhD (University of California, San Francisco), John Wiencke, PhD (University of California, San Francisco), Margaret Wrensch, PhD (University of California, San Francisco).


Abstract

Epidemiologists in the Brain Tumor Epidemiology Consortium (BTEC) have prioritized areas for further research. Although many risk factors have been examined over the past several decades, there are few consistent findings, possibly because of small sample sizes in individual studies and differences between studies in patients, tumor types, and methods of classification. Individual studies generally have lacked samples of sufficient size to examine interactions. A major priority based on available evidence and technologies includes expanding research in genetics and molecular epidemiology of brain tumors. BTEC has taken an active role in promoting understudied groups, such as pediatric brain tumors; the etiology of rare glioma subtypes, such as oligodendroglioma; and meningioma, which, although it is not uncommon, has only recently been registered systematically in the United States. There also is a pressing need for more researchers, especially junior investigators, to study brain tumor epidemiology. However, relatively poor funding for brain tumor research has made it difficult to encourage careers in this area. In this report, BTEC epidemiologists reviewed the group's consensus on the current state of scientific findings, and they present a consensus on research priorities to identify which important areas the science should move to address. Cancer 2008;113(7 suppl):1953–68. © 2008 American Cancer Society.

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