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Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998–2003†‡§

  1. A. Blythe Ryerson MPH1,¶,*,
  2. Edward S. Peters DMD, ScD2,
  3. Steven S. Coughlin PhD, MPH1,
  4. Vivien W. Chen PhD2,
  5. Maura L. Gillison MD, PhD3,
  6. Marsha E. Reichman PhD4,
  7. Xiaocheng Wu MD, MPH2,
  8. Anil K. Chaturvedi PhD5,
  9. Kelly Kawaoka MD1

Article first published online: 3 NOV 2008

DOI: 10.1002/cncr.23745

Issue

Cancer

Cancer

Supplement: Assessing the Burden of HPV-Associated Cancers in the United States

Volume 113, Issue Supplement 10, pages 2901–2909, 15 November 2008

Additional Information

How to Cite

Ryerson, A. B., Peters, E. S., Coughlin, S. S., Chen, V. W., Gillison, M. L., Reichman, M. E., Wu, X., Chaturvedi, A. K. and Kawaoka, K. (2008), Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998–2003. Cancer, 113: 2901–2909. doi: 10.1002/cncr.23745

Author Information

  1. 1

    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia

  2. 2

    Louisiana Tumor Registry, Epidemiology Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana

  3. 3

    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

  4. 4

    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland

  5. 5

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland

  1. Fax: (770) 488-4639.

*Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, K-55, Atlanta, GA 30341-3724

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    We appreciate the in-kind support from all the contributors to this supplement. We also thank Amy Chen, MD, MPH, for her input on the categorization of anatomic sites for this analysis.

  3. §

    The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Publication History

  1. Issue published online: 3 NOV 2008
  2. Article first published online: 3 NOV 2008
  3. Manuscript Accepted: 2 JUN 2008
  4. Manuscript Revised: 29 MAY 2008
  5. Manuscript Received: 14 APR 2008

Funded by

  • Cooperative Agreement. Grant Number: U50 DP424071-04
  • Centers for Disease Control and Prevention (CDC)

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Keywords:

  • cancer;
  • human papillomavirus;
  • oral cancer;
  • oropharyngeal cancer

Abstract

BACKGROUND.

As human papillomavirus (HPV) vaccination becomes widely available in the US for cervical cancer prevention, it may also affect the rates of other cancers potentially associated with HPV. The objective of the current study was to describe the incidence rates of oropharyngeal and oral cavity cancers in the US with a focus on anatomic sites potentially associated with HPV infection.

METHODS.

Incident cases diagnosed between 1998 and 2003 identified through 39 population-based registries that participate in the National Program of Cancer Registries and/or the Surveillance, Epidemiology, and End Results Program were examined. The incidence rates of potentially HPV-associated oropharyngeal and oral cavity cancers by various characteristics were estimated. The 1998 through 2003 trends in these rates were also compared with rates for sites not previously shown to be associated with HPV (comparison sites).

RESULTS.

In all, 44,160 cases of potentially HPV-associated cancers of the oropharynx and oral cavity were identified, including 19,239 (43.6%) tonsillar, 16,964 (38.4%) base of tongue, and 7957 (18.0%) other oropharyngeal cancers. The incidence rates for these sites were highest among blacks, and higher among non-Hispanics and men than among Hispanics and women. The annual incidence rates of potentially HPV-associated cancers of the tonsil and base of tongue both increased significantly from 1998 through 2003 (annual percentage change [APC], 3.0; P < .05 for both sites), whereas the incidence rates of cancer at the comparison sites generally decreased.

CONCLUSIONS.

The results of the current study provide baseline incidence rates of potentially HPV-associated cancers of the oropharynx and oral cavity that can be compared with rates after the widespread implementation of the HPV vaccination. Cancer 2008;113(10 suppl):2901–9. Published 2008 by the American Cancer Society.

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