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Neuroendocrine tumor epidemiology
Contrasting Norway and North America
Article first published online: 13 OCT 2008
Copyright © 2008 American Cancer Society
Volume 113, Issue 10, pages 2655–2664, 15 November 2008
How to Cite
Hauso, O., Gustafsson, B. I., Kidd, M., Waldum, H. L., Drozdov, I., Chan, A. K. C. and Modlin, I. M. (2008), Neuroendocrine tumor epidemiology. Cancer, 113: 2655–2664. doi: 10.1002/cncr.23883
- Issue published online: 3 NOV 2008
- Article first published online: 13 OCT 2008
- Manuscript Accepted: 19 JUN 2008
- Manuscript Revised: 17 JUN 2008
- Manuscript Received: 28 MAR 2008
- Norwegian Research Council
- Caroline Musæus Aarvolds legacy
- Bruggeman Medical Foundation
- Norwegian Registry of Cancer
The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program has proven to be a significant resource in US neuroendocrine tumor (NET) epidemiology. Norway also holds a robust and detailed cancer registry: the Norwegian Registry of Cancer (NRC).
SEER NET data were compared with corresponding NRC data in the time period 1993 to 2004 to determine whether there are differences in NET epidemiology between Norway and the United States.
The SEER and NRC reported 17,312 and 2030 NETs, respectively. The overall Caucasian SEER NET incidence was 4.44, compared with 3.24 in the NRC. In the SEER white subset, bronchopulmonary NETs were the most common (incidence = 1.42; 32% of all NETs), compared with small intestinal NETs in the NRC (0.81; 26%). A marked increase in SEER NET incidence (37%-40%) was observed in the period 2000 to 2004, compared with 1993 to 1997; an even more pronounced increase (72%) was seen in the NRC. African Americans exhibited a remarkably high overall NET incidence of 6.50; furthermore, among African Americans, rectal NETs were most common (1.65; 27%). Small intestinal NET incidence was ∼30% higher in men compared with women in all populations. The highest 5-year survival rates were for rectal NETs (74%-88%) in both databases, whereas prostatic NETs had the worst outcome (0%-23%). At diagnosis, NETs were localized in 27% to 46% of patients.
NET incidence in the US Caucasian population and in Norway is similar, but considerably higher (∼50%) among African Americans. NETs have been regarded as indolent tumors; however, the 5-year survival is only ∼55%. Cancer 2008. © 2008 American Cancer Society.