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Desmoplastic neurotropic melanoma
A clinicopathologic analysis of 128 cases
Article first published online: 29 SEP 2008
Copyright © 2008 American Cancer Society
Volume 113, Issue 10, pages 2770–2778, 15 November 2008
How to Cite
Chen, J. Y., Hruby, G., Scolyer, R. A., Murali, R., Hong, A., FitzGerald, P., Pham, T. T., Quinn, M. J. and Thompson, J. F. (2008), Desmoplastic neurotropic melanoma. Cancer, 113: 2770–2778. doi: 10.1002/cncr.23895
- Issue published online: 3 NOV 2008
- Article first published online: 29 SEP 2008
- Manuscript Accepted: 30 JUN 2008
- Manuscript Revised: 4 JUN 2008
- Manuscript Received: 26 MAR 2008
- adjuvant radiation treatment;
- local recurrence;
Several studies have suggested that desmoplastic neurotropic melanoma (DNM) is associated with higher local recurrence rates than other types of melanoma. The authors investigated the local recurrence rates for patients with DNM after surgery alone or surgery followed by radiotherapy (RT).
One hundred twenty-eight patients with DNM were treated at the Sydney Melanoma Unit and the Sydney Cancer Center from 1996 to 2007. All patients underwent local excision, 27 patients also received RT. For both groups, clinical and pathologic features, treatment details, and local recurrence data were analyzed.
The median age at diagnosis was 65.5 years. The ratio of men to women was 2.7:1. The head and neck was the most common location (51%). The median Breslow thickness was 4 mm, and 99% of patients had Clark Level IV or V primary tumors. Patients who received adjuvant RT had thicker tumors (P = .003), deeper Clark level invasion (P < .001), and narrower excision margins (P < .001). There were 8 local recurrences, including 6 (6%) in the surgery only group and 2 (7%) in the adjuvant RT group. A positive margin (P < .001) and head and neck location (P = .03) were significant predictors of local recurrence.
The local recurrence rate in this series was lower than the rates reported in historic control groups and in the authors' previous temporal cohort. The results indicated that clear surgical margins are of paramount importance in minimizing local recurrence; when margins are compromised, the addition of RT may reduce local recurrence rates compared with historic controls. A prospective randomized trial is needed to quantify the risk reduction with adjuvant RT. Cancer 2008. © 2008 American Cancer Society.