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Risk of cholecystitis in patients with cancer
A population-based cohort study in Denmark
Article first published online: 24 OCT 2008
Copyright © 2008 American Cancer Society
Volume 113, Issue 12, pages 3410–3419, 15 December 2008
How to Cite
Thomsen, R. W., Thomsen, H. F., Nørgaard, M., Cetin, K., McLaughlin, J. K., Tarone, R. E., Fryzek, J. P. and Sørensen, H. T. (2008), Risk of cholecystitis in patients with cancer. Cancer, 113: 3410–3419. doi: 10.1002/cncr.23961
- Issue published online: 4 DEC 2008
- Article first published online: 24 OCT 2008
- Manuscript Accepted: 21 JUL 2008
- Manuscript Revised: 15 JUL 2008
- Manuscript Received: 28 JAN 2008
- International Epidemiology Institute
- Amgen Inc., Thousand Oaks, California
- cohort study
To the authors' knowledge, little information is available regarding the incidence of cholecystitis among patients with cancer.
The authors conducted a population-based historical cohort study of 51,228 patients with incident cancer, identified in medical databases of western Denmark between 1995 and 2003. A general population comparison cohort of 512,280 persons was assembled using the Danish Civil Registration System. The occurrence of cholecystitis in the 2 groups was determined by linkage to the regional Hospital Discharge Registry.
In all, 230 incident diagnoses of cholecystitis were identified in the cancer cohort during 130,185 person-years (median follow-up time: 1.6 years), corresponding to an incidence rate of 1.8 of 1000 person-years. After adjustment for confounders, the relative risk (RR) for cholecystitis among cancer patients compared with the general population cohort was 1.38 (95% confidence interval [95% CI], 1.20-1.58). Overall, the RR for cholecystitis was doubled during the first 6 months after cancer diagnosis (RR = 1.95; 95% CI, 1.50-2.54), after which the RR declined but remained greater than 1 throughout the rest of the follow-up period (RR = 1.23; 95% CI, 1.05-1.45). Cancer patients between the ages of 51 and 70 years had the highest risk increase for cholecystitis compared with other age groups. During the first 6 months after a cancer diagnosis, pancreatic cancers (12 cholecystitis events; RR = 9.44 [95% CI, 5.18-17.18]) and colorectal cancers (10 cholecystitis events; RR = 4.98 [95% CI, 2.65-9.34]) were found to be associated with the greatest cholecystitis risk increase compared with other tumor types. After 6 months, most cancers were associated with a relatively small increased risk, although there was an RR of 4.72 (95% CI, 1.99-11.21) based on 5 cholecystitis events among thyroid cancer patients.
The results of the current study indicate that cholecystitis occurs more frequently among cancer patients than in the general population, particularly within the first 6 months after a cancer diagnosis. Clinicians who treat cancer patients should remain vigilant about this type of infection. Cancer 2008. © 2008 American Cancer Society.