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Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients†
A pilot study
Article first published online: 5 NOV 2008
Copyright © 2008 American Cancer Society
Volume 113, Issue 12, pages 3430–3439, 15 December 2008
How to Cite
Jones, L. W., Eves, N. D., Peterson, B. L., Garst, J., Crawford, J., West, M. J., Mabe, S., Harpole, D., Kraus, W. E. and Douglas, P. S. (2008), Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients. Cancer, 113: 3430–3439. doi: 10.1002/cncr.23967
Poster presented at the 44th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, May 30, 2008–June 3, 2008.
- Issue published online: 4 DEC 2008
- Article first published online: 5 NOV 2008
- Manuscript Accepted: 6 JUN 2008
- Manuscript Revised: 23 MAY 2008
- Manuscript Received: 20 MAR 2008
- Lance Armstrong Foundation
- aerobic exercise;
- nonsmall cell lung cancer;
- cardiopulmonary fitness;
- quality of life
A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted.
Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic cycle ergometry sessions per week at 60% to 100% of peak workload for 14 weeks. Peak oxygen consumption (VO2peak) was assessed using an incremental exercise test. QOL and fatigue were assessed using the Functional Assessment of Cancer Therapy–Lung (FACT-L) scale.
Nineteen patients completed the study. Intention-to-treat analysis indicated that VO2peak increased 1.1 mL/kg−1/min−1 (95% confidence interval [CI], −0.3-2.5; P = .109) and peak workload increased 9 W (95% CI, 3-14; P = .003), whereas FACT-L increased 10 points (95% CI, −1-22; P = .071) and fatigue decreased 7 points (95% CI; −1 to −17; P = .029) from baseline to postintervention. Per protocol analyses indicated greater improvements in cardiopulmonary and QOL endpoints among patients not receiving adjuvant chemotherapy.
This pilot study provided proof of principle that supervised aerobic training is safe and feasible for postsurgical NSCLC patients. Aerobic exercise training is also associated with significant improvements in QOL and select cardiopulmonary endpoints, particularly among patients not receiving chemotherapy. Larger randomized trials are warranted. Cancer 2008. © 2008 American Cancer Society.