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Gene expression signature for recurrence in stage III colorectal cancers

  1. Toshiaki Watanabe MD, PhD1,†,*,
  2. Takashi Kobunai MSc1,
  3. Etsuko Sakamoto MSc2,
  4. Yoko Yamamoto PhD1,
  5. Tsuyoshi Konishi MD, PhD3,
  6. Atsushi Horiuchi MD1,
  7. Ryu Shimada MD1,
  8. Toshinori Oka PhD2,
  9. Hirokazu Nagawa MD, PhD3

Article first published online: 17 NOV 2008

DOI: 10.1002/cncr.24023

Issue

Cancer

Cancer

Volume 115, Issue 2, pages 283–292, 15 January 2009

Additional Information

How to Cite

Watanabe, T., Kobunai, T., Sakamoto, E., Yamamoto, Y., Konishi, T., Horiuchi, A., Shimada, R., Oka, T. and Nagawa, H. (2009), Gene expression signature for recurrence in stage III colorectal cancers. Cancer, 115: 283–292. doi: 10.1002/cncr.24023

Author Information

  1. 1

    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan

  2. 2

    Personalized Medicine Research Laboratory, Tokushima Research Center, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan

  3. 3

    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan

  1. †

    Fax: (011) 81-3-5375-6097

*Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

Publication History

  1. Issue published online: 7 JAN 2009
  2. Article first published online: 17 NOV 2008
  3. Manuscript Accepted: 13 AUG 2008
  4. Manuscript Revised: 6 AUG 2008
  5. Manuscript Received: 11 FEB 2008

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Keywords:

  • colorectal cancer;
  • recurrence;
  • lymph node metastasis;
  • stage III;
  • microarray;
  • prediction;
  • copy number;
  • CABIN1;
  • Duke stage C;
  • tailored therapy

The study showed that gene expression profiling is useful in predicting recurrence in stage III colorectal cancer. The authors identified CABIN1 among discriminating genes that may play a key role in the development of recurrence.

Abstract

BACKGROUND:

Colorectal cancer patients with lymph node metastases (stage III) show poorer prognosis than those without. Predicting development of recurrence may guide the need for intensive follow-up and/or adjuvant chemotherapy in such patients. The authors' objective was to identify a set of discriminating genes that could predict recurrence in stage III colorectal cancer.

METHODS:

Thirty-six stage III colorectal cancer patients were studied. Tumor samples were obtained from surgically resected specimens. Thirteen patients developed recurrence, whereas 23 patients did not. Gene expression profiles were determined using human HG-U133 Plus 2.0 Gene Chip (Affymetrix, Santa Clara, Calif).

RESULTS:

The authors identified 45 discriminating genes between patients with and without recurrence. By using this gene set, they established a new model to predict recurrence with an accuracy of 90.9%. The discriminating genes included calcineurin-binding protein 1 (CABIN1), whose expression differed remarkably between patients with and without recurrence (P = .0073). The authors further examined the DNA copy number of CABIN1 and were able to show a significant relation with recurrence (P < .012). Patients having CABIN1 gene loss demonstrated a higher risk of recurrence (odds ratio, 18.8). DNA copy number of CABIN1 alone could predict recurrence with an accuracy of 80.0%.

CONCLUSIONS:

The results of the current study demonstrated that gene expression profiling is useful in predicting recurrence in stage III colorectal cancer. The authors identified CABIN1 among discriminating genes that may play a key role in the development of recurrence. These results may help to establish an individualized therapy for stage III colorectal cancer. Cancer 2009. © 2009 American Cancer Society.

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