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Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma†
Are response evaluation criteria in solid tumors reliable?
Article first published online: 30 DEC 2008
Copyright © 2008 American Cancer Society
Volume 115, Issue 3, pages 616–623, 1 February 2009
How to Cite
Forner, A., Ayuso, C., Varela, M., Rimola, J., Hessheimer, A. J., de Lope, C. R., Reig, M., Bianchi, L., Llovet, J. M. and Bruix, J. (2009), Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma. Cancer, 115: 616–623. doi: 10.1002/cncr.24050
We thank Mrs. Diana Segarra for her editorial assistance.
- Issue published online: 20 JAN 2009
- Article first published online: 30 DEC 2008
- Manuscript Accepted: 15 AUG 2008
- Manuscript Revised: 13 AUG 2008
- Manuscript Received: 7 JUL 2008
- Carlos III Institute of Health. Grant Numbers: PI 06/132, PI 05/645
- BBVA Foundation
- Scientific Foundation of the Spanish Cancer Association
- hepatocellular carcinoma;
- locoregional therapies;
- Response Evaluation Criteria in Solid Tumors;
- tumor response assessment
Evaluation of response to treatment is a key aspect in cancer therapy. Response Evaluation Criteria in Solid Tumors (RECIST) are used in most oncology trials, but those criteria evaluate only unidimensional tumor measurements and disregard the extent of necrosis, which is the target of all effective locoregional therapies. Therefore, the European Association for the Study of the Liver (EASL) guidelines recommended that assessment of tumor response should incorporate the reduction in viable tumor burden. The current report provides an assessment of the agreement/concordance between both RECIST and the EASL guidelines for the evaluation of response to therapy.
The authors evaluated a cohort of 55 patients within prospective studies, including 24 patients with hepatocellular carcinoma who underwent transarterial chemoembolization (TACE) with drug eluting beads (DEB-TACE) and 31 patients who underwent percutaneous ablation (percutaneous ethanol injection [PEI]/radiofrequency [RF]). Triphasic helical computed tomography scans were performed at baseline, at 1 month, and at 3 months after procedure, and 2 independent radiologists evaluated tumor response.
Evaluating response according to RECIST criteria, no patients achieved a complete response (CR), 21.8% of patients achieved a partial response (PR) (none in the PEI/RF group), 47.3% of patients had stable disease (SD), and 30.9% of patients had progressive disease (PD). When response was evaluated according to the EASL guidelines, 54.5% of patients achieved a CR, 27.3% of patients achieved a PR, 3.6% of patients had SD, and 14.5% had PD. The κ coefficient was 0.193 (95% confidence interval, 0.0893-0.2967; P < .0001).
RECIST missed all CRs and underestimated the extent of partial tumor response because of tissue necrosis, wrongly assessing the therapeutic efficacy of locoregional therapies. This evaluation should incorporate the reduction in viable tumor burden as recognized by nonenhanced areas on dynamic imaging studies. Cancer, 2009. © 2008 American Cancer Society.