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Routine perioperative chemotherapy instillation with initial bladder tumor resection
A reconsideration of economic benefits
Article first published online: 22 JAN 2009
Copyright © 2009 American Cancer Society
Volume 115, Issue 5, pages 997–1004, 1 March 2009
How to Cite
Rao, P. K. and Stephen Jones, J. (2009), Routine perioperative chemotherapy instillation with initial bladder tumor resection. Cancer, 115: 997–1004. doi: 10.1002/cncr.24104
- Issue published online: 18 FEB 2009
- Article first published online: 22 JAN 2009
- Manuscript Accepted: 15 SEP 2008
- Manuscript Revised: 18 AUG 2008
- Manuscript Received: 10 JUN 2008
- urinary bladder;
- perioperative care;
- drug therapy;
Level-1 evidence has demonstrated decreased recurrence of low-grade bladder tumors when initial transurethral resection (TUR) is followed by perioperative instillation (PI) of chemotherapy. A meta-analysis determined that the number needed to treat (NNT) was 8.5 patients to prevent 1 recurrence. No benefit was demonstrated for tumors classified as T0, tumor in situ, or T2; thus, patients with those tumors were excluded from the analysis, which potentially may have resulted in underestimating the true NNT. Economic benefits were suggested, but cost calculations were not presented. The objectives of the current analysis were to recalculate the NNT considering patients who previously were excluded and to examine the economic implications based on various management alternatives for tumor recurrence.
For each study that was included in the current meta-analysis, the number of patients excluded because of ‘inappropriate’ pathology results was determined. A potentially more accurate NNT was calculated, and pertinent Medicare reimbursements were obtained to estimate costs.
The added cost for 8.5 patients who underwent inpatient TUR to receive PI was $1711. Inpatient TUR ($7025) was extremely costly compared with hospital outpatient TUR ($2666), ambulatory surgery center TUR ($2113), and physician office fulguration ($1167). Although the inclusion of patients who previously were excluded resulted in a recalculated NNT of 9.6 patients, the authors used a more conservative NNT if 8.5 patients to estimate the economic impact of the ‘best-case scenario.’
Routine PI significantly lowered the overall cost if recurrences were managed in the inpatient setting, but these benefits were offset mostly or completely by outpatient management in the United States. Thus, the authors concluded that the decision to use routine PI of chemotherapy should be based on clinical effects and not on presumed economic benefits. Cancer 2009. © 2009 American Cancer Society.