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Original Article
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Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy†
Article first published online: 23 JAN 2009
DOI: 10.1002/cncr.24166
Copyright © 2009 American Cancer Society
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How to Cite
Rudloff, U., Brogi, E., Brockway, J. P., Goldberg, J. I., Cranor, M., Wynveen, C. A., Nehhozina, T., Reiner, A. S., Patil, S. and Van Zee, K. J. (2009), Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. Cancer, 115: 1203–1214. doi: 10.1002/cncr.24166
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Presented in part at the 2008 Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, May 30 to June 3, 2008.
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Publication History
- Issue published online: 3 MAR 2009
- Article first published online: 23 JAN 2009
- Manuscript Accepted: 20 OCT 2008
- Manuscript Received: 26 AUG 2008
Corrected by:
Correction: Correction
Vol. 116, Issue 8, 2064, Article first published online: 11 FEB 2010
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Keywords:
- high-risk proliferative breast cancer lesions;
- ductal carcinoma in situ;
- lobular carcinoma in situ;
- lobular neoplasia;
- ipsilateral breast tumor recurrence;
- breast conservation
Abstract
BACKGROUND:
Multiple clinicopathologic factors have been analyzed for their association with an increased risk of ipsilateral breast tumor recurrence (IBTR) after women receive breast-conserving treatment (BCT) for ductal carcinoma in situ (DCIS). The reported incidence of proliferative lesions, such as atypical ductal hyperplasia (ADH), columnar cell changes (CCC), and lobular neoplasia associated with breast cancer, has been as high as 23%; however, the relevance of these lesions on the natural history of DCIS and the risk of IBTR remains unknown.
METHODS:
Two hundred ninety-four patients with DCIS who received BCT between 1991 and 1995 were identified from the authors' institutional database. Slides were reviewed by a dedicated breast pathologist with particular attention to the presence of lobular neoplasia, ADH, and CCC. The actuarial 5-, 10-, and 15-year IBTR rates were calculated using the Kaplan-Meier method and were compared using the log-rank test.
RESULTS:
Concurrent lobular neoplasia was present in 41 of 294 patients (14%), ADH was present in 37 of 294 patients (13%), and CCC was present in 71 of 294 patients (24%). The median follow-up was 11 years. IBTR occurred in 40 of 227 patients without lobular neoplasia (18%) versus 15 of 41 patients with lobular neoplasia (37%; P=.005; hazard ratio [HR], 2.49). The 5-, 10-, and 15-year cumulative incidence rates of IBTR were twice as high in women who had DCIS and lobular neoplasia compared with women who had DCIS alone (P=.002). Concomitant ADH (HR, 1.53) and CCC (HR, 1.24) were not associated significantly with IBTR (P=.20 and P=.44, respectively).
CONCLUSIONS:
Concurrent lobular neoplasia is associated with a significantly higher risk of IBTR in women with DCIS who received BCT. Women with coexisting DCIS and lobular neoplasia who receive BCT should consider using additional risk-reducing strategies. Cancer 2009. © 2009 American Cancer Society.