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Colon cancer patient information seeking and the adoption of targeted therapy for on-label and off-label indications†
Article first published online: 23 FEB 2009
DOI: 10.1002/cncr.24186
Copyright © 2009 American Cancer Society
Additional Information
How to Cite
Gray, S. W., Armstrong, K., DeMichele, A., Schwartz, J. S. and Hornik, R. C. (2009), Colon cancer patient information seeking and the adoption of targeted therapy for on-label and off-label indications. Cancer, 115: 1424–1434. doi: 10.1002/cncr.24186
- †
The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations, or conclusions.
Publication History
- Issue published online: 19 MAR 2009
- Article first published online: 23 FEB 2009
- Manuscript Accepted: 21 OCT 2008
- Manuscript Revised: 25 SEP 2008
- Manuscript Received: 11 JUL 2008
Funded by
- National Cancer Institute. Grant Number: 5P50CA095856-05
References
- 1,. Regaining the initiative. Forging a new model of the patient-physician relationship. JAMA. 1996; 275: 887-891.
- 2,. Patient-centered medicine. A professional evolution. JAMA. 1996; 275: 152-156.
- 3,,,. Reconceptualizing the “patient”: health care promotion as increasing citizens' decision-making competencies. Health Commun. 1997; 9: 61-74.
- 4. Cancer-Related Information Seeking. Cresskill, NJ: Hampton Press, Inc.; 1997.
- 5,. Decision making in medicine and health care. Annu Rev Clin Psychol. 2005; 1: 525-556.
- 6,,,. The Health Information National Trends Survey: research from the baseline. J Health Commun. 2006; 11( suppl 1): vii-xvi.
- 7. Science and society: the communications revolution and cancer control. Nat Rev Cancer. 2005; 5: 828-835.
- 8. The impact of the Internet on cancer outcomes. CA Cancer J Clin. 2003; 53: 356-371.Direct Link:
- 9,,. The impact of CyberHealthcare on the physician-patient relationship. J Med Syst. 2003; 27: 67-84.
- 10,The Online Health Care Revolution: How the Web Helps Americans Take Better Care of Themselves: The Pew Internet and American Life Project, Volume 2007. Washington, DC: Pew Charitable Trusts; 2000.
- 11,,. American oncologists' views of Internet use by cancer patients: a mail survey of American Society of Clinical Oncology members. J Clin Oncol. 2003; 21: 942-947.
- 12,,, et al. Attitudes of oncology health professionals to information from the Internet and other media. Med J Aust. 2005; 183: 197-200.
- 13,. A new strategy for cancer control research. Cancer Epidemiol Biomarkers Prev. 1999; 8: 957-964.
- 14,,,,. An analysis of the diffusion of new antidepressants: variety, quality, and marketing efforts. J Ment Health Policy Econ. 2002; 5: 3-19.
- 15,. Turf battles in coronary revascularization. N Engl J Med. 2005; 352: 857-859.
- 16,. Regulatory perspectives on pharmacogenomics: a review of the literature on key issues faced by the United States Food and Drug Administration. Med Care Res Rev. 2006; 63: 301-326.
- 17,,. Racial disparity and technology diffusion: the case of cardioverter defibrillator implants, 1996-2001. J Natl Med Assoc. 2007; 99: 201-207.
- 18,,,,. Are minority children the last to benefit from a new technology? Technology diffusion and inhaled corticosteriods for asthma. Med Care. 2006; 44: 81-86.
- 19,,,. Diffusion of surgical techniques in early stage breast cancer: variables related to adoption and implementation of sentinel lymph node biopsy. Ann Surg Oncol. 2007; 14: 1662-1669.
- 20. Adoption of new surgical technology. BMJ. 2006; 332: 112-114.
- 21,,. The diffusion of an innovation among physicians. Sociometry. 1957; 20: 253-270.
- 22,,,. Information, marketing, and pricing in the US antiulcer drug market. Am Econ Rev. 1995; 85: 100-105.
- 23,,,,. Houseofficers' reactions to media coverage about the sequencing of the human genome. Soc Sci Med. 2003; 56: 2211-2220.
- 24,,,. Importance of the lay press in the transmission of medical knowledge to the scientific community. N Engl J Med. 1991; 325: 1180-1183.
- 25,,,,,. Relationship of Internet health information use with patient behavior and self-efficacy: experiences of newly diagnosed cancer patients who contact the National Cancer Institute's Cancer Information Service. J Health Commun. 2006; 11: 219-236.
- 26,,. The determinants and consequences of information seeking among cancer patients. J Health Commun. 2003; 8: 529-562.
- 27,, Cancer information scanning and seeking behavior is associated with knowledge, lifestyle choices, and screening. J Health Commun. 2006; 11( suppl 1): 157-172.
- 28,,, et al. Study of the media's potential influence on prospective research participants' understanding of and motivations for participation in a high-profile phase I trial. J Clin Oncol. 2002; 20: 3785-3791.
- 29Mail and Internet Surveys: The Tailored Design Method, 2nd ed. New York, NY: John Wiley & Sons; 2000.
- 30American Association for Public Opinion Research. Standard Definitions: Final Dispositions of Case Codes and Outcome Rates for Surveys, 4th ed. Lenexa, Kan: American Association for Public Opinion Research; 2006.
- 31,,, et al. Influence of patients' requests for direct-to-consumer advertised antidepressants: a randomized controlled trial. JAMA. 2005; 293: 1995-2002.
- 32,,, et al. How does direct-to-consumer advertising (DTCA) affect prescribing? A survey in primary care environments with and without legal DTCA. CMAJ. 2003; 169: 405-412.
- 33,,,,,. Consumers' reports on the health effects of direct-to-consumer drug advertising [supplemental web exclusives]. Health Aff (Millwood). 2003; W3( suppl): 82-95.
- 34,,. Off-label prescribing among office-based physicians. Arch Intern Med. 2006; 166: 1021-1026.
- 35,. Reimbursement policies constrain the practice of oncology. JAMA. 1991; 266: 2996-2999.
- 36,. Effect of off-label use of oncology drugs on pharmaceutical costs: the rituximab experience. Am J Manag Care. 2003; 9: 393-400; quiz 401-402.
- 37,,, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007; 25: 1539-1544.
- 38,,, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004; 350: 2335-2342.
- 39,,, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004; 351: 337-345.
- 40Biological therapy and other novel therapies in early-stage disease: are they appropriate? Clin Cancer Res. 2007; 13(22 pt 2): 6909s-6912s.
- 41. Regulating off-label drug use—rethinking the role of the FDA. N Engl J Med. 2008; 358: 1427-1429.
- 42,,. National trends in cyclooxygenase-2 inhibitor use since market release: nonselective diffusion of a selectively cost-effective innovation. Arch Intern Med. 2005; 165: 171-177.
- 43US lawmakers seek J&J, Amgen anemia drug records. Washington, DC: Reuters; 2008. Available at: http://www.reuters.com/article/marketsNews/idUSN0130607820080401. [Accessed on September 23, 2008.]
- 44. Two steps forward in the treatment of colorectal cancer. N Engl J Med. 2004; 350: 2406-2408.
- 45,, Falling Through the Net: Defining the Digital Divide. A Report on the Telecommunications and Information Technology Gap in America. Washington, DC: National Telecommunications and Information Administration, U.S. Department of Commerce; 1999.
- 46,,,,,. Health information, the Internet, and the digital divide. Health Aff (Millwood). 2000; 19: 255-265.
- 47,. Health and the information nonseeker: a profile. Health Commun. 2006; 20: 131-139.
- 48,,. Cancer-related information seeking: hints from the 2003 Health Information National Trends Survey (HINTS). J Health Commun. 2006; 11( suppl 1): 147-156.
- 49. Cancer patients seeking information from sources outside the health care system. Support Care Cancer. 2000; 8: 453-457.
- 50,,,,,. Cancer patients seeking a second surgical opinion: results of a study on motives, needs, and expectations. J Clin Oncol. 2003; 21: 1492-1497.
- 51,,,. Quality assurance of second opinion pathology in gynecologic oncology. Obstet Gynecol. 1999; 94: 302-306.
- 52,,,,,. Discrepancy between second and first opinion in surgical oncological patients. Eur J Surg Oncol. 2006; 32: 108-112.
- 53,,,,,. Agreement between patient report and medical record review for medications used for rheumatoid arthritis: the accuracy of self-reported medication information in patient registries. Arthritis Rheum. 2007; 57: 234-239.Direct Link:
- 54,,,,,. Agreement between self-reported antihypertensive drug use and pharmacy records in a population-based study in the Netherlands. Pharm World Sci. 1999; 21: 217-220.
- 55,,,,. Cardiovascular diseases and risk factors in a population-based study in the Netherlands: agreement between questionnaire information and medical records. Neth J Med. 1999; 55: 177-183.

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