The first two authors contributed equally to this article.
Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma
Article first published online: 20 FEB 2009
Copyright © 2009 American Cancer Society
Volume 115, Issue 9, pages 1995–2003, 1 May 2009
How to Cite
Liu, L., Liang, S., Li, L., Mao, Y., Tang, L., Tian, L., Liao, X., Cui, C., Lin, A. and Ma, J. (2009), Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer, 115: 1995–2003. doi: 10.1002/cncr.24201
- Issue published online: 20 APR 2009
- Article first published online: 20 FEB 2009
- Manuscript Accepted: 21 OCT 2008
- Manuscript Revised: 20 SEP 2008
- Manuscript Received: 23 JUN 2008
- Science Foundation of Key Hospital Clinical Program of the Ministry of Health P.R. China. Grant Number: 2007-353
- Hi-Tech Research and Development Program of China. Grant Number: 2006AA02AA404
- Science Foundation of the Sci-Tech Office of Guangdong Province. Grant Number: 2005B30301003
- nasopharyngeal carcinoma;
- MRI-detected cranial nerve involvement;
The purpose of this study was to evaluate the prognostic value of magnetic resonance imaging (MRI)-detected cranial nerve (CN) involvement in nasopharyngeal carcinoma (NPC).
Retrospective analysis was made of the magnetic resonance images and medical records of 924 consecutive patients with newly diagnosed NPC.
Of 924 patients, 82 (8.9%) initially presented with CN palsy. CN involvement was seen on MRI in 333 (36%) patients. In T3-4 disease, MRI-evidenced CN involvement was associated with poor 3-year overall survival (OS) (35.7% vs 89.2%, P = .001) and distant metastasis-free survival (DMFS) (77.1% vs 87.8%, P = .002) rates. The survival curves of OS and DMFS for T3 disease with MRI-detected CN involvement approximated those of T4 disease (P = .322 and P = .809, respectively). In patients with MRI-detected CN involvement, no significant differences were observed in 3-year OS (78.3% vs 72.9%, P = .120), local relapse-free survival (LRFS) (89.7% vs 84.1%, P = .154), or DMFS (79.6% vs 74.8%, P = .466) rates between those with and without intracranial or orbital CN involvement. Furthermore, in patients with clinical and/or MRI-detected CN involvement, there were no significant differences in the 3-year OS (74.2% vs 80.1%, P = .067), LRFS (86.7% vs 87.9%, P = .899), or DMFS (74.6% vs 84.6%, P = .094) rates between symptomatic and asymptomatic patients.
The incidence of MRI-detected CN involvement was higher than CN palsy. MRI-detected CN involvement has a negative impact on the prognosis independent of lesion localization and symptoms. Cancer 2009. © 2009 American Cancer Society.