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Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population†
Article first published online: 20 APR 2009
Copyright © 2009 American Cancer Society
Volume 115, Issue 12, pages 2693–2700, 15 June 2009
How to Cite
Xu, W.-H., Long, J.-r., Zheng, W., Ruan, Z.-x., Cai, Q., Cheng, J.-r., Xiang, Y.-B. and Shu, X.-O. (2009), Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population. Cancer, 115: 2693–2700. doi: 10.1002/cncr.24289
This study would not have been possible without the support of the study participants and research staff of the Shanghai Endometrial Cancer Study.
- Issue published online: 4 JUN 2009
- Article first published online: 20 APR 2009
- Manuscript Accepted: 26 NOV 2008
- Manuscript Revised: 20 NOV 2008
- Manuscript Received: 23 JUN 2008
- Vanderbilt Ingram Cancer Center. Grant Number: P30 CA68485
- Vanderbilt Diabetes Research and Training Center. Grant Number: P60 DK20593
- Vanderbilt Digestive Disease Center. Grant Number: P30 DK58404
- Vanderbilt Vision Center. Grant Number: P30 EY08126
- progesterone receptor gene;
- single nucleotide polymorphism;
- endometrial cancer
Single nucleotide polymorphisms (SNPs) in the progesterone receptor (PGR) gene have been associated with the risk of endometrial cancer. However, to the authors' knowledge, no study to date has systematically evaluated the role of the PGR gene in endometrial carcinogenesis.
Exposure information and DNA samples collected in the Shanghai Endometrial Cancer Study, a population-based case-control study of 1204 incident cases and 1212 age- and frequency-matched population controls, were used in this study. Seven tag SNPs were identified for the PGR gene plus the 5-kilobase (kb) flanking regions using the Han Chinese data from the HapMap project with a pairwise correlation coefficient (r2) ≥ 0.90. These 7 SNPs captured 92% of SNPs in the region with a pairwise r2 ≥ 0.90 or 100% of SNPs with a pairwise r2 ≥ 0.80. Genotyping of polymorphisms was performed by using the Affymetrix MegAllele Targeted Genotyping System. A logistic regression model was used to compute adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs).
Of 7 tag SNPs that were assessed, 2 polymorphisms in the 3′ flanking region of the PGR gene, reference SNP identification number (rs) 11224561 (rs11224561) and rs471767, were associated with the risk of endometrial cancer. The cytosine/cytosine (CC) genotype of SNP rs11224561 was associated with decreased risk (OR, 0.68; 95% CI, 0.50-0.92) compared with the thymine/thymine (TT) genotype. Carrying the guanine (G) allele of the rs471767 SNP also was associated with decreased risk, although the association was not statistically significant (OR, 0.78, 95%CI, 0.59-1.04 and OR, 0.32, 95%CI, 0.03-3.05 for the adenine [A]G and GG genotypes, respectively, compared with the homozygote AA).
The current findings suggested that polymorphisms in the 3′ flanking region of the PGR gene may be associated with the risk of endometrial cancer. Cancer 2009. © 2009 American Cancer Society.