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Prediction of sexual function after radical prostatectomy†

  1. Alberto Briganti MD1,‡,*,
  2. Umberto Capitanio MD1,
  3. Felix K.-H. Chun MD2,
  4. Pierre I. Karakiewicz MD3,
  5. Andrea Salonia MD1,
  6. Marco Bianchi MD1,
  7. Andrea Cestari MD1,
  8. Giorgio Guazzoni MD1,
  9. Patrizio Rigatti MD1,
  10. Francesco Montorsi MD1

Article first published online: 19 JUN 2009

DOI: 10.1002/cncr.24349

Issue

Cancer

Cancer

Supplement: Predictive Modeling in Prostate Cancer, Supplement to Cancer

Volume 115, Issue Supplement 13, pages 3150–3159, 1 July 2009

Additional Information

How to Cite

Briganti, A., Capitanio, U., Chun, F. K.-H., Karakiewicz, P. I., Salonia, A., Bianchi, M., Cestari, A., Guazzoni, G., Rigatti, P. and Montorsi, F. (2009), Prediction of sexual function after radical prostatectomy. Cancer, 115: 3150–3159. doi: 10.1002/cncr.24349

Author Information

  1. 1

    Department of Urology, Vita-Salute University, San Raffaele Hospital, Milan, Italy

  2. 2

    Department of Urology, University of Hamburg, Hamburg, Germany

  3. 3

    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Canada

  1. ‡

    Fax: (011) 39-02-26437298

*Department of Urology, Vita Salute University-San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy

  1. †

    Presented at the Inside Track Conference, “Predictive Modeling in Prostate Cancer,” organized by the European School of Oncology, Venice, Italy, April 17-19, 2008.

Publication History

  1. Issue published online: 19 JUN 2009
  2. Article first published online: 19 JUN 2009
  3. Manuscript Accepted: 6 FEB 2009
  4. Manuscript Revised: 3 FEB 2009
  5. Manuscript Received: 22 SEP 2008

Funded by

  • ASTRA Zeneca
  • European School of Oncology

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Keywords:

  • erectile dysfunction;
  • radical prostatectomy;
  • treatment;
  • predictive factors

Abstract

Radical prostatectomy (RP) is a commonly used procedure in the treatment of clinically localized prostate cancer. For this report, the authors critically analyzed the factors associated with recovery of erectile function after surgery. A systematic review of the literature using the Medline and CancerLit databases was conducted. Keywords for the literature search included prostate cancer, radical prostatectomy, erectile dysfunction, impotence, treatment, and prophylaxis. Accurate patient selection (based on patient age, preoperative erectile function, and comorbidity profile) and adequate surgical technique (ie, the preservation of neurovascular bundles) were the major determinants of postoperative erectile function. Moreover, better results were achieved when an appropriate pharmacologic treatment using either oral or local approaches was given. Therefore, the authors concluded that, if patients are stratified correctly according to preoperative, intraoperative, and postoperative factors, then a satisfactory functional recovery may be expected after surgery. For these reasons, an ideal multivariate model predicting the restoration of erectile function after surgery should include patient, surgeon, and postsurgical treatment variables. The authors also concluded that the stratification of patients with regard to their risk of developing erectile dysfunction after surgery was feasible based on several parameters, which should be taken into account for correct patient treatment and counseling. To address this objective, accurate tools for predicting the likelihood of complete functional recovery after surgery are needed. Cancer 2009;115(13 suppl):3150–9. © 2009 American Cancer Society.

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