• sex;
  • women;
  • research;
  • neoplasms;
  • publications



Adequate representation of women in research has been deemed essential.


Cancer research published in 8 journals in 2006 was reviewed. The percentage of women among study participants was compared with the proportion expected from population-based estimates of sex-specific cancer incidence, using binomial tests. Differences were assessed in sex distribution of participants by funding source, author sex, and focus of research with the Student t test, and in a linear regression model controlling for cancer type.


A total of 1534 cancer research articles were identified, of which 661 (representing 1,096,098 participants) were prospective clinical studies and were analyzed further. For all 7 non-sex–specific cancer types assessed, the majority of studies analyzed included a lower proportion of women than the proportion of women among patients having cancer of that type in the general population. Among studies focusing on cancer treatment, women constituted a significantly lower overall proportion of the participants in the analyzed studies than expected for 6 of 7 non-sex–specific cancer types (P < .001). Among non-sex–specific studies, the mean percentage of participants who were women was 38.8%. Non-sex–specific studies reporting government funding had a higher percentage of female participants (mean 41.3% vs 36.9%; P = .005). In a regression model controlling for cancer type, lack of government funding (P = .03) and focus on cancer treatment (P = .03) were found to be independent significant predictors of a lower percentage of female participants.


Women were under-represented as participants in recently published, high-impact studies of non-sex–specific cancers. Studies that received government funding included a higher proportion of female subjects. Cancer 2009. © 2009 American Cancer Society.