• antioxidants;
  • dietary supplements;
  • breast cancer;
  • chemotherapy;
  • radiation therapy;
  • hormonal therapy


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References


Although many patients take antioxidant dietary supplements during breast cancer treatment, the benefits of such supplementation are unproven. The authors of this report analyzed the prevalence of and factors associated with antioxidant supplement use during breast cancer (BC) treatment among women who participated in the Long Island Breast Cancer Study Project.


From 2002 through 2004, women with BC who had participated a case-control study from 1996 to 1997 were invited to participate in a follow-up interview. Antioxidant supplement use was defined as any self-reported intake of supplemental vitamin C, vitamin E, β-carotene, or selenium in individual supplements or multivitamins.


Follow-up interview participants were younger, more predominantly white, and of higher socioeconomic status than women who did not respond. Among 764 participants who completed the follow-up interview, 663 (86.8%) reported receiving adjuvant treatment for their BC. Of those 663 women, 401 (60.5%) reported using antioxidants during adjuvant treatment: One hundred twenty of 310 women (38.7%) used antioxidants during chemotherapy, 196 of 464 women (42.2%) used them during radiation, and 286 of 462 women (61.9%) used them during tamoxifen therapy. Of 401 antioxidant users, 278 women (69.3%) used high doses (doses higher than those contained in a Centrum multivitamin). The factors that were associated with high antioxidant supplement use during treatment were higher fruit and vegetable intake at diagnosis (relative risk [RR], 1.71; 95% confidence interval [CI], 1.13-2.59), tamoxifen use (RR, 3.66; 95% CI, 2.32-5.78), ever using herbal products (RR, 3.49; 95% CI, 2.26-5.38), and ever engaging in mind-body practices (RR, 1.72; 95% CI, 1.13-2.64).


Given the common use of antioxidant supplements during BC treatment, often at high doses and in conjunction with other complementary therapies, future research should address the effects of antioxidant supplementation on BC outcomes. Cancer 2009. © 2009 American Cancer Society.

An estimated 45% to 87% of patients with breast cancer use antioxidant supplements after diagnosis.1-9 However, to our knowledge, the characteristics of women who use antioxidants specifically during treatment for breast cancer have not been described previously.

Many patients with breast cancer take antioxidant supplements, because they believe antioxidants will protect them from the side effects of breast cancer treatment, help prevent breast cancer recurrence, and improve their overall health.7 However, the actual consequences of using antioxidant supplements during cancer treatment are poorly understood and controversial.10-18 In the past few decades, the idea that antioxidant supplementation could protect normal tissue from the adverse effects of cancer treatments has become widespread.19

Radiation therapy and some chemotherapeutic agents induce apoptosis by generating reactive oxygen species, which damage tumor cell DNA and disrupt mitochondrial membranes.20-22 Many medical and radiation oncologists believe that antioxidant supplements interfere with this process and that antioxidant use during treatment may reduce therapeutic efficacy.14 However, the effects of taking antioxidant supplements during cancer therapy on cancer recurrence or mortality and the characteristics of antioxidant users have not been well studied.18, 23

We determined the prevalence and predictors of antioxidant supplement use, taken as multivitamins and as single vitamin supplements, during breast cancer treatment among women with breast cancer who participated in the population-based Long Island Breast Cancer Study Project (LIBCSP). To our knowledge, ours is the first detailed study of antioxidant use during treatment in a cohort study setting.


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References


The LIBCSP began as a federally mandated, population-based, case-control study to investigate whether breast cancer risk was associated with environmental exposures among women in Nassau and Suffolk counties in New York State.24 A subsequent follow-up study was conducted among cases to determine whether environmental exposures were associated with mortality. The LIBCSP case-control study cases (n = 1508) were women who were diagnosed with a first primary in situ or invasive breast cancer between August 1, 1996 and July 31, 1997. Cases were identified by rapid ascertainment methods through daily or weekly contact with local pathology departments of hospitals known to diagnose and treat residents of Nassau and Suffolk counties with newly diagnosed breast cancer, including some hospitals in New York City. Once a case was identified, her physician was contacted to verify the diagnosis and to obtain permission to contact the patient. Among eligible cases, the response rate for the parent case-control study was 82.1%.

For the LIBCSP follow-up, which was conducted between 2002 and 2004, interviewers attempted to conduct telephone interviews with all cases who previously agreed to be contacted again (n = 1414; 93.8%),24 and 1098 cases (77.7%) completed a full or short-form interview in person or by proxy. The study reported here is based on the 784 cases (55.4%) who personally completed the full follow-up interview.

Written, signed informed consent was obtained from all participants before the beginning of the in-person baseline interview. The study protocol was approved by all institutional review boards of the collaborating institutions.

Data Collection

Baseline case-control questionnaire

The baseline questionnaire was administered to participants in their homes shortly after they were diagnosed (mean, 96 days) with a first primary breast cancer. The questionnaire asked about known and suspected risk factors for breast cancer (available at:; accessed on October 10, 2008). A 101-item, modified Block food frequency questionnaire was self-administered. Baseline questionnaire variables that were used in the analyses presented here included age at diagnosis, race/ethnicity, education, annual household income, marital status, body mass index, family history of breast cancer, menopausal status at diagnosis, mammogram history, oral contraceptive use, hormone-replacement therapy use, lifetime physical activity, smoking history, previous alcohol use, and fruit and vegetable intake.

Follow-up questionnaire among cases

The follow-up questionnaire asked about breast cancer recurrence risk factors, including demographics, health behaviors, medical history, first course of treatment received, and other clinical variables. The questionnaire included detailed questions about complementary and alternative medicine (CAM) therapy use during 3 separate periods: before, during, and after breast cancer diagnosis and treatment. The CAM modalities that were assessed included multivitamins, single vitamins, minerals, herbal products, other over-the-counter health products, mind-body activities (eg, spirituality, support groups, meditation), special treatments (eg, biofeedback, colon cleansing, hydrotherapy), alternative cancer clinics, special diets (eg, vegan, macrobiotic, low-fat diets), and visits with CAM practitioners. The analyses presented here focus on antioxidant supplement use during treatment. Analyses of other CAM use will be presented in a separate article.

Study participants who reported ever using multivitamins were asked whether they used them during specific phases of their treatment, including surgery, chemotherapy, radiation therapy, and tamoxifen therapy. In addition, participants were asked how many tablets were consumed per week since diagnosis. The questionnaire asked about specific types of multivitamins: multivitamins with minerals, multivitamins without minerals, antioxidant combination types with vitamins A, C, and E; stress-tab types, women's formula types; multivitamins with herbs; and other multivitamins. For the current analysis, we assumed that each multivitamin pill contained the doses of specific micronutrients present in the commonly used Centrum multivitamin circa 2002 (60 mg vitamin C, 30 IU vitamin E, 20 μg selenium, 5000 IU β-carotene).25 To estimate the daily doses consumed during treatment of vitamin C, vitamin E, selenium, and β-carotene from multivitamins, we multiplied the Centrum dose of each individual micronutrient by the number of multivitamin tablets a participant reported taking per week and dividing by 7.

Data were collected in a similar fashion on the use of individual antioxidant supplements during breast cancer treatment, including vitamin C, vitamin E, selenium, and β-carotene. For each individual supplement, data were collected on dose per tablet and number of tablets taken per week since diagnosis and were used to estimate daily doses consumed during treatment.

Less than 4% of participants were missing data on individual antioxidant supplement use (β-carotene, 1.3%; vitamin C, 2.5%; vitamin E; 3.5%, selenium, 2.4%). We assumed that participants who reported taking 1 of these supplements but who provided no information on dose had taken the lowest dose. We conducted sensitivity analyses to determine whether assuming the median dose or the highest dose would make any appreciable differences in our results, and it did not.

To estimate individual intake of each antioxidant during treatment (vitamin C, vitamin E, selenium, and β-carotene), we added the daily dose values for the multivitamins and the individual supplements. Then, intake of each supplement was categorized as none, low, or high. High doses were defined as >60 mg vitamin C, >30 IU vitamin E, >20 μg selenium, and >5000 IU β-carotene; these cutoff points were based on the doses in a typical Centrum multivitamin circa 2002. Between 1997 and 2004, the Food and Nutrition Board of the Institute of Medicine revised its nutrient intake recommendations, now termed Dietary Reference Intakes (DRIs).26, 27 The current DRIs are 90 mg vitamin C, 22 IU natural vitamin E (33 IU synthetic vitamin E), and 55 μg selenium.28 There is no DRI for β-carotene.

We created a composite antioxidant index to summarize total intake of supplemental β-carotene, vitamin C, vitamin E, and selenium during treatment. We computed a categorical variable with a range from 0 points to 8 points based on scoring the intake of each antioxidant as never (0), low (1), or high (2). The antioxidant index itself was divided into 3 categories: none (score, 0), low (score,1-4), and high (score, 5-8).

Medical records

Signed medical records release forms were obtained from case women at the baseline and follow-up interviews. Medical records were obtained from inpatient and outpatient facilities involved in the diagnosis, treatment, and follow-up of breast cancer cases. Medical records were abstracted at baseline and at follow-up to ascertain tumor characteristics and first course of treatment for the primary breast cancer diagnosis. For the 598 women who had complete medical records data available on the first course of treatment, the agreement between self-reported breast cancer treatment and treatment recorded on the medical record was high for chemotherapy (κ = 0.96), radiation therapy (κ = 0.97), and hormone therapy (κ = 0.92).29 Thus, for the current analyses, we used treatment information collected through self-report during the follow-up interview.

Statistical Analyses

Chi-square tests and Student t tests were used to evaluate the statistical significance of the associations of the demographic, health behavior, clinical, and CAM use variables with antioxidant supplement use during treatment. Multivariate logistic and polytomous regression analyses were performed to identify independent predictors of antioxidant use, which were categorized as either none/any or none/low dose/high dose. Model-building procedures were performed in the following 3 basic steps. In Step 1, candidate predictors were identified as the predictors that were statistically significant (P < .10) in unadjusted analyses30 as well as any a priori confounders. Step 2 involved fitting a full model that included all variables identified in Step 1, in which variables were retained in the model if the corresponding P value was <.05. Finally, in Step 3, variables that were rejected in the first step were added back to the model, 1 at a time, for reassessment and were kept in the final model if the corresponding P value was <.05. Tests of significance were based on the likelihood ratio test statistic. Analyses were performed using Stata software (version 9.2; StataCorp., College Station, Tex).


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References


In total, 784 individuals personally completed the full telephone interview. They were younger, more educated, more likely to be white, and had higher household income than women who did not respond to the follow-up questionnaire (Table 1). Of 784 women, 764 provided data on antioxidant supplement use (Table 2). Their mean age at the time of diagnosis with a first primary breast cancer was 56.3 years (±11.4 years), and 94% were non-Hispanic whites. Greater than 60% of the women had at least some college education. In total, 555 of 764 respondents (72.6%) used multivitamin or single antioxidant supplements before diagnosis, and the number of users increased to 650 of 764 (85.1%) after diagnosis. All 764 women underwent surgical treatment for their breast cancer, and 663 (86.8%) also received adjuvant treatment: 310 (40.6%) received chemotherapy, 464 (60.7%) received radiation therapy, and 462 (60.5%) received tamoxifen. Of 663 women who received adjuvant treatment, 560 (84.5%) reported using antioxidants after their breast cancer diagnosis, and 401 (60.5%) specifically reported using antioxidants during their treatment. Women who received adjuvant treatment did not differ from those who did not receive such treatment with respect to antioxidant use after diagnosis (data not shown).

Table 1. Demographic and Breast Cancer-related Characteristics at Diagnosis of Responders and Nonresponders
CharacteristicResponders (n=764)Nonresponders (n=724)P*
  • *

    P values are based on chi-square tests and do not include individuals who had missing data.

Demographic characteristics     
 Age at diagnosis, y     
  Non-Hispanic white71894.062686.5<.001
  Hispanic white202.6273.7 
  Black/African American152.0547.5 
  ≤High school graduate30139.440956.5<.001
  Some college19525.516022.1 
  College graduate11114.57810.8 
 Annual household income     
Breast cancer-related characteristics     
  ≥5 y ago111.4283.9 
  Within past 5 y72194.462386.0 
 Stage at diagnosis     
  In situ13717.99513.10.01
Table 2. Demographic, Clinical, and Lifestyle Characteristics of Study Participants by Antioxidant Supplement Use During Adjuvant Treatment (n=764)
CharacteristicNo Adjuvant Treatment (n=101)Antioxidant Supplement Use During Chemotherapy, Radiotherapy, or Hormonal Therapy (n=663)P
No Use (n=262)Low-dose Use (n=169)High-dose Use (n=232)
  1. ER indicates estrogen receptor; −, negative; PR, progesterone receptor; +, positive; NA, not available; BMI, body mass index; CAM, complementary and alternative medicine; NE, not estimable; OTC, over the counter.

Demographic characteristics         
 Age at diagnosis, y         
  Non-Hispanic white9897.024693.916195.321391.8.233
  Hispanic white22.083.131.873.0 
  Black/African American11.062.342.441.7 
  ≤High school graduate2726.711744.78147.97632.8.001
  Some college2524.86625.24325.46126.3 
  College graduate1817.84015.31911.23414.7 
 Annual household income at diagnosis         
Clinical characteristics         
  In situ7271.3249.21810.7239.9<.001
 Hormone receptor status         
 Treatments received         
  ChemotherapyNA 11945.48147.911047.4<.001
  RadiotherapyNA 18169.111869.816571.1<.001
  Hormonal therapyNA 15258.012574.018579.7<.001
 BMI at diagnosis, kg/m2         
 Family history of breast cancer         
 Menopausal status at diagnosis         
Health behavior characteristics before diagnosis         
  Never had mammogram00.083.184.752.2.325
  Had mammogram >5 y ago22.020.831.841.7 
  Had mammogram ≤5 y ago9998.024693.915792.921994.4 
 Oral contraceptive use         
Hormone replacement therapy use         
Physical activity (from menarche to diagnosis), h/wk
Smoking history         
 Current (within 12 mo)1514.96223.73218.93314.2 
Alcohol use         
Fruit and vegetable intake, servings/wk
CAM use (ever)         
 Any CAM101100.025296.2169100.0232100.0NE
 Single vitamins8887.118269.513781.122998.7<.001
 Herbal supplements4847.58231.35633.114462.1<.001
 Other OTC healthcare products4039.67127.14828.49038.8.010
 Mind-body activities5453.511242.77645.014763.4<.001
 Special treatments65.962.310.6114.7.032
 Alternative cancer clinics00.
 Special diets3938.68231.34224.99741.8.002
 CAM practitioners4544.67629.04727.89340.1.002

Factors Associated With Antioxidant Use During Specific Treatments

Of 310 women who received chemotherapy, 120 women (38.7%) used antioxidants during chemotherapy. Antioxidant use during chemotherapy was positively associated with ever having used herbal products and high fruit and vegetable intake before diagnosis (Table 3). Of 464 women who received radiation therapy, 196 (42.2%) used antioxidants during radiation therapy. Antioxidant use during radiation therapy was positively associated with ever having used herbal products and having in situ (as opposed to invasive) disease (Table 3). Of 462 women who received tamoxifen treatment for their breast cancer, 286 (61.9%) used antioxidants during that treatment. Antioxidant use during tamoxifen therapy was positively associated with ever having used herbal products, lower body mass index (<25 kg/m2), moderate lifetime alcohol intake, and family history of breast cancer.

Table 3. Adjusted Analyses of Antioxidant Supplement Use During Chemotherapy, Radiation Therapy, and Tamoxifen Therapy
VariableAntioxidant Use During Chemotherapy, n=309Antioxidant Use During Radiotherapy, n=464Antioxidant Use During Tamoxifen Therapy, n=452
  1. OR indicates odds ratio; CI, confidence interval; BMI, body mass index.

  2. *The ORs displayed are for the variables that were included in each model.

Age at diagnosis (per y)1.020.99-
Race (vs non-Hispanic white)  .53  .67  .23
 Hispanic white0.460.08-2.58 0.570.17-1.96 0.750.20-2.80 
 Black/African American0.860.19-3.91 0.890.24-3.30 3.690.41-32.88 
 Other2.940.45-19.42 1.760.45-6.92 4.350.50-37.45 
Education (vs ≤high school graduate)  .66  .43  .10
 Some college0.810.43-1.53 1.460.91-2.34 1.290.77-2.17 
 College graduate0.630.29-1.39 1.160.62-2.16 0.560.29-1.09 
 Postgraduate0.730.37-1.43 1.340.78-2.30 1.240.68-2.24 
BMI (vs <25), kg/m2        .03
 25-<30      0.540.34-0.87 
 ≥30      0.600.34-1.06 
Lifetime alcohol intake (vs nondrinkers), g/d  .009
 <15      0.810.52-1.27 
 15-30      2.841.23-6.56 
 ≥30      1.510.52-4.40 
Family history of breast cancer (yes vs no)      1.821.07-3.09.02
Fruit and vegetable intake (vs <35 servings/wk)  .05      
 ≥35 servings/wk1.641.00-2.69       
Stage (invasive vs in situ)   0.510.28-0.94.03   
Herbal products (ever vs never)2.711.64-4.49<.0011.741.17-2.57.0062.311.49-3.58<.001

Antioxidant Supplement Dose Used During Treatment

Of 401 women who used antioxidants during therapy, 342 (51.6%) used multivitamins, 199 (30%) used individual vitamin C, 215 (32.4%) used individual vitamin E, 54 (8.1%) used individual selenium, and 14 (2.1%) used individual β-carotene (data not shown). Of all 401 women, 278 (69.3%) used high doses of antioxidant supplements; of 376 women who used any form of vitamin C (from multivitamins or as an individual supplement), 211 (56.1%) used >60 mg per day (Table 4); of 392 women who used any form of vitamin E, 224 (57.1%) used >30 IU per day; of 352 women who used any form of selenium, 88 (25%) used >20 μg per day; and, of 345 women who used any form of β-carotene, 54 (15.7%) used >5000 IU per day.

Table 4. Distribution of No Use, Low-dose Use, and High-dose Use for Total Intake of Antioxidant Supplements During Treatment (n=663)
AntioxidantAntioxidant Supplement Use During Treatment (n=663)
No UseLow-dose UseHigh-dose Use
  • *

    The high vitamin C dose was >60 mg.

  • The high vitamin E dose was >30 IU.

  • The high selenium dose was >20 μg.

  • §

    The high β-carotene dosewas >5000 IU.

Vitamin C*28743.316524.921131.8
Vitamin E27140.916825.322433.8
Antioxidant index26239.516925.523235.0

Antioxidant Index

Of 663 women who received any adjuvant therapy treatment, 232 (35%) scored high on the antioxidant index, which is a proxy for simultaneous high-dose use of multiple antioxidant supplements. In the polytomous model for predicting levels of antioxidant use during treatment, the strongest predictor low-dose antioxidant use during treatment was tamoxifen use (Table 5). The strongest predictors of high-dose antioxidant use during treatment were high fruit and vegetable intake before diagnosis, tamoxifen use, ever using herbal products, and ever using mind-body activities.

Table 5. Adjusted Analyses Using Polytomous Logistic Regression for Antioxidant Use During Any Treatment (n=642)
VariableLow-dose Antioxidant Supplement Use (n=164)*High-dose Antioxidant Supplement Use (N=228)*P
RR95% CIRR95% CI
  • RR indicates relative risk; 95% CI, 95% confidence interval; Ref, reference category; OTC products, over the counter products.

  • *

    Compared with nonusers (n=250) of antioxidant supplements during treatment.

  • P values were based on a likelihood ratio test of significance for each variable in the final, adjusted, polytomous regression model.

Age at diagnosis (per y)1.000.98-
 Non-Hispanic whiteRef Ref .11
 Hispanic white0.710.17-2.901.040.33-3.20 
 ≤High schoolRef Ref .62
 Some college0.960.58-1.591.060.63-1.77 
 College graduate0.560.28-1.100.790.42-1.46 
Fruit and vegtables, servings/wk     
 <35Ref Ref .03
Family history of breast cancer     
 NoRef Ref  
 NeverRef Ref  
Herbal products     
 NeverRef Ref  
Other OTC products     
 NeverRef Ref  
Mind-body activities     
 NeverRef Ref  
Special diets     
 NeverRef Ref  


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References

Among women with breast cancer who participated in the LIBCSP follow-up study, 38.7% reported antioxidant supplement use during chemotherapy, 42.2% reported antioxidant supplement use during radiation therapy, and 61.9% reported antioxidant supplement use during tamoxifen therapy. Greater than 50% of the study participants who used antioxidants during treatment consumed doses that exceeded the DRI.

The majority of participants in our study were well educated, non-Hispanic white, postmenopausal women with high household incomes who engaged in other health-oriented behaviors before diagnosis (eg, regular physical activity, high fruit and vegetable intake, not smoking), and we believe our results are generalizable to similar populations. Almost all participants reported previous use of 1 or more forms of CAM. Most women who reported antioxidant supplement use during treatment, especially those who used high doses, also engaged in other health-oriented behaviors. Women who used high-dose antioxidant supplements during treatment were much more likely ever to have used herbal products and ever to have received tamoxifen therapy than women who did not use antioxidant supplements.

Antioxidant supplement use appears to have been more prevalent among the Long Island breast cancer patients in our sample than among respondents to the 2000 National Health Interview Survey. In that sample 51% of women, including 62% of non-Hispanic white women, reported using vitamins or minerals anytime in the past year.31 However, in a literature review of women who had a history of breast cancer, from 67% to 87% reported using vitamins and minerals9; those rates are similar to our observations.

We observed a strong association between antioxidant supplement use and tamoxifen use. This association may reflect tamoxifen users' strategies to manage vasomotor symptoms associated with this therapy (eg, taking vitamin E supplements to help with hot flashes32). We did not ask women about their motives for dietary supplement use during treatment; however, previous studies have demonstrated that women may take supplements to counteract toxicities due to breast cancer treatment.7

To our knowledge, this study is the first to report on antioxidant use during specific phases of breast cancer treatment. A recent review identified 8 articles that reported on vitamin/mineral supplement use among breast cancer survivors,9 but only 1 of those articles focused on the 12 months postresection.33 A report from the Nurses Health Study indicated that 20% of breast cancer survivors used high-dose vitamins during the 2 years before the assessment (mean, 3.2 years postdiagnosis).6 Among Canadian breast cancer patients (mean, 2.4 years postdiagnosis), 51% reported ever using vitamins and minerals other than those in a multivitamin; to treat symptoms associated with breast cancer, 13.2% used vitamin E, 12.3% used vitamin C, and 6% used β-carotene.8 Neither study reported on use during specific breast cancer treatments.

Another strength of the current study is our cumulative antioxidant index and categorization of study participants as high-dose, low-dose, or nonusers of multiple forms of antioxidants. We developed this approach to exposure measurement because antioxidants rarely are taken alone and may have cumulative physiologic effects. Although our categorization of antioxidant use as low-dose or high-dose was based on detailed questionnaire data, at best, it is an approximation of actual intake. We were conservative in calculating the specific doses of antioxidants consumed in multivitamins; therefore, we may have underestimated some actual doses.

The main limitation of our study is its relatively low response rate, especially compared with the high response rate of the original LIBCSP case-control study. However, we have complete first-hand follow-up questionnaire data on 764 of 1414 women (55.4%) who agreed to be contacted again for the follow-up study, including the CAM questionnaire. Our response bias analyses (data not shown) revealed that women who completed the full questionnaire were of higher socioeconomic status than those who did not. Because such women also are more likely than others to use CAM,34 our study participants may have been heavier users of antioxidants than breast cancer patients in the general population.

The follow-up survey was conducted at least 5 years after participants were diagnosed with a first primary breast cancer. The passage of time may have led to poor recall of supplement use before diagnosis and during treatment. Despite possible misclassification, our analyses identified strong predictors of supplement use that are consistent with those reported by other investigators.3, 35, 36

Data on the actual effects of antioxidant supplements during breast cancer treatment are limited.37 Some studies of antioxidant supplement use during treatment of other cancer sites have suggested harm.18 In a randomized clinical trial of patients who were undergoing radiation therapy for head and neck cancers, α-tocopherol supplementation (400 IU/day for 3 years beginning at the initiation of radiation therapy) was associated with a decrease in both adverse side effects during treatment38 and overall survival at 8 years.39 However, patients with head and neck cancer may differ from breast cancer patients in behaviors, such as tobacco use, that may be relevant to the effects of antioxidants. The effects of antioxidant supplementation during treatment also may depend on the doses and types of supplements, intake of fruits and vegetables, tumor site and stage, type of treatment, and genetic polymorphisms in endogenous antioxidant enzymes.

Areas in which further research is needed include the physiologic interactions between antioxidants and radiation therapy, chemotherapy, and hormone therapy; whether there is a dose threshold above which an antioxidant exerts benefit or harm; and the long-term effect of antioxidants on breast cancer recurrence and survival. Prospective observational studies and clinical trials need to elucidate whether antioxidants affect treatment toxicities, treatment efficacy, and recurrence and survival. Our data suggest that many women diagnosed with breast cancer who use antioxidant supplements also are engaging in other behaviors that may affect their risk of recurrence, and these behaviors should be accounted for in studies of antioxidant supplements during treatment. The results of these studies will shed light on whether or not patients can use antioxidant supplements to enhance the effects of conventional treatment or alleviate its side effects without adversely affecting their prospects for survival.

In summary, we observed that the majority of breast cancer patients in Long Island, many of whom were of high socioeconomic status, used antioxidants during treatment. We believe that oncologists should discuss supplement use and dosing with their patients. More specifically, oncologists can inform patients that antioxidant supplements may dampen the effects of chemotherapy and radiation therapy but that clear evidence of benefit or harm is not yet available.9, 18, 37


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References

We thank the women of Nassau and Suffolk Counties, New York who participated in the Long Island Breast Cancer Study Project for their valuable contributions.

Conflict of Interest Disclosure

  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References

Supported by a grant from the Lance Armstrong Foundation; by National Cancer Institute and National Institutes of Environmental Health and Sciences grants U01CA/ES66572, U01CA66572, CA52283, and P30ES10126; and by National Cancer Institute grant R25 CA09406.


  1. Top of page
  2. Abstract
  6. Acknowledgements
  7. Conflict of Interest Disclosure
  8. References
  • 1
    Lengacher CA, Bennett MP, Kip KE, et al. Frequency of use of complementary and alternative medicine in women with breast cancer. Oncol Nurs Forum. 2002; 29: 1445-1452.
  • 2
    VandeCreek L, Rogers E, Lester J. Use of alternative therapies among breast cancer outpatients compared with the general population. Altern Ther Health Med. 1999; 5: 71-76.
  • 3
    Demark-Wahnefried W, Peterson B, McBride C, Lipkus I, Clipp E. Current health behaviors and readiness to pursue life-style changes among men and women diagnosed with early stage prostate and breast carcinomas. Cancer. 2000; 88: 674-684.
  • 4
    Henderson JW, Donatelle RJ. Complementary and alternative medicine use by women after completion of allopathic treatment for breast cancer. Altern Ther Health Med. 2004; 10: 52-57.
  • 5
    Navo MA, Phan J, Vaughan C, et al. An assessment of the utilization of complementary and alternative medication in women with gynecologic or breast malignancies. J Clin Oncol. 2004; 22: 671-677.
  • 6
    Buettner C, Kroenke CH, Phillips RS, Davis RB, Eisenberg DM, Holmes MD. Correlates of use of different types of complementary and alternative medicine by breast cancer survivors in the nurses' health study. Breast Cancer Res Treat. 2006; 100: 219-227.
  • 7
    Boon H, Stewart M, Kennard MA, et al. Use of complementary/alternative medicine by breast cancer survivors in Ontario: prevalence and perceptions. J Clin Oncol. 2000; 18: 2515-2521.
  • 8
    Boon HS, Olatunde F, Zick SM. Trends in complementary/alternative medicine use by breast cancer survivors: comparing survey data from 1998 and 2005 [serial online]. BMC Womens Health. 2007; 7: 4.
  • 9
    Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol. 2008; 26: 665-673.
  • 10
    Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology (Williston Park). 1999; 13: 1003-1008; discussion 1008, 1011-1012.
  • 11
    Hamilton KK. Antioxidant supplements during cancer treatments: where do we stand? Clin J Oncol Nurs. 2001; 5: 181-182.
  • 12
    Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev. 1999; 4: 304-329.
  • 13
    Lamson DW, Brignall MS. Antioxidants and cancer therapy II: quick reference guide. Altern Med Rev. 2000; 5: 152-163.
  • 14
    D'Andrea GM. Use of antioxidants during chemotherapy and radiotherapy should be avoided. CA Cancer J Clin. 2005; 55: 319-321.
  • 15
    Prasad KN. Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Integr Cancer Ther. 2004; 3: 310-322.
  • 16
    Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 2. Altern Ther Health Med. 2007; 13: 40-47.
  • 17
    Simone CB 2nd, Simone NL, Simone V, Simone CB. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med. 2007; 13: 22-28.
  • 18
    Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst. 2008; 100: 773-783.
  • 19
    Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer. 2008; 123: 1227-1239.
  • 20
    Weijl NI, Cleton FJ, Osanto S. Free radicals and antioxidants in chemotherapy-induced toxicity. Cancer Treat Rev. 1997; 23: 209-240.
  • 21
    Sangeetha P, Das UN, Koratkar R, Suryaprabha P. Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer. Free Radic Biol Med. 1990; 8: 15-19.
  • 22
    Hellman S. Principles of radiation therapy. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 4th ed. Philadelphia, Pa: JB Lippincott; 1993.
  • 23
    Ladas EJ, Jacobson JS, Kennedy DD, Teel K, Fleischauer A, Kelly KM. Antioxidants and cancer therapy: a systematic review. J Clin Oncol. 2004; 22: 517-528.
  • 24
    Gammon MD, Neugut AI, Santella RM, et al. The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat. 2002; 74: 235-254.
  • 25
    Wyeth Consumer Healthcare. Centrum multivitamins [package insert]. Wilmington, Del: Wyeth Consumer Healthcare; 2002. Available at: Accessed on June 24, 2002.
  • 26
    Council for Responsible Nutrition. Historical Comparison of RDIs, RDA, and DRIs, 1968 to Present for Vitamins. Washington, DC: Council for Responsible Nutrition; 2007.
  • 27
    Council for Responsible Nutrition. Historical Comparison of RDIs, RDA, and DRIs, 1968 to Present for Minerals. Washington, DC: Council for Responsible Nutrition; 2007.
  • 28
    Institute of Medicine, Committee on Use of Dietary Reference Intakes in Nutrition Labeling. Dietary Reference Intakes. Washington, DC: National Academy of Sciences; 2004.
  • 29
    Fink BN, Gaudet MM, Britton JA, et al. Fruits, vegetables, and micronutrient intake in relation to breast cancer survival. Breast Cancer Res Treat. 2006; 98: 199-208.
  • 30
    Collett D. Modelling Survival Data in Medical Research. Boca Raton, Fla: Chapman & Hall/CRC; 2003.
  • 31
    Millen AE, Dodd KW, Subar AF. Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: The 1987, 1992, and 2000 National Health Interview Survey results. J Am Diet Assoc. 2004; 104: 942-950.
  • 32
    Barton DL, Loprinzi CL, Quella SK, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol. 1998; 16: 495-500.
  • 33
    Burstein HJ, Gelber S, Guadagnoli E, Weeks JC. Use of alternative medicine by women with early stage breast cancer. N Engl J Med. 1999; 340: 1733-1739.
  • 34
    Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. 2004; 27: 1-19.
  • 35
    Morris KT, Johnson N, Homer L, Walts D. A comparison of complementary therapy use between breast cancer patients and patients with other primary tumor sites. Am J Surg. 2000; 179: 407-411.
  • 36
    Patterson RE, Neuhouser ML, Hedderson MM, et al. Types of alternative medicine used by patients with breast, colon, or prostate cancer: predictors, motives, and costs. J Altern Complement Med. 2002; 8: 477-485.
  • 37
    Greenlee H, Hershman DL, Jacobson JS. Use of antioxidant supplements during breast cancer treatment: A comprehensive review. Breast Cancer Res Treat. In press.
  • 38
    Bairati I, Meyer F, Gelinas M, et al. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J Clin Oncol. 2005; 23: 5805-5813.
  • 39
    Bairati I, Meyer F, Gelinas M, et al. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst. 2005; 97: 481-488.