1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
The first 2 authors contributed equally to this article.
1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
Original Article
You have full text access to this OnlineOpen article
Glioblastoma in the elderly
The Memorial Sloan-Kettering Cancer Center Experience (1997-2007)
Article first published online: 29 MAY 2009
DOI: 10.1002/cncr.24413
Copyright © 2009 American Cancer Society
Additional Information
How to Cite
Iwamoto, F. M., Cooper, A. R., Reiner, A. S., Nayak, L. and Abrey, L. E. (2009), Glioblastoma in the elderly. Cancer, 115: 3758–3766. doi: 10.1002/cncr.24413
Publication History
- Issue published online: 3 AUG 2009
- Article first published online: 29 MAY 2009
- Manuscript Accepted: 12 JAN 2009
- Manuscript Revised: 7 JAN 2009
- Manuscript Received: 17 NOV 2008
Funded by
- Memorial Sloan-Kettering Cancer Center Medical Student Summer Fellowship Program
References
- 1, , , . Epidemiology of brain tumors. Neurol Clin. 2007; 25: 867-890, vii.
- 2Central Brain Tumor Registry of the United States. 2007-2008 primary brain tumors in the United States statistical report 2000-2004 (years of data collected). Hinsdale, IL: CBTRUS; 2008.
- 3, , , et al. Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res. 2004; 10( 1 pt 1): 228-233.
- 4, , , et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005; 352: 987-996.
- 5, , , et al. Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma. J Neurosurg. 2008; 108: 642-648.
- 6, , , , . Patterns of care in elderly glioblastoma patients. Ann Neurol. 2008; 64: 628-634.Direct Link:
- 7, . Glioma extent of resection and its impact on patient outcome. Neurosurgery. 2008; 62: 753-764, discussion 264-266.
- 8, . Glioma in the elderly. Curr Opin Oncol. 2006; 18: 644-647.
- 9, , , . Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir (Wien). 2003; 145: 5-10.
- 10, . The limited value of cytoreductive surgery in elderly patients with malignant gliomas. Neurosurgery. 1994; 34: 62-66, discussion 66-67.
- 11, , , et al. Radiotherapy for glioblastoma in the elderly. N Engl J Med. 2007; 356: 1527-1535.
- 12, , , et al. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol. 2004; 22: 1583-1588.
- 13, , , , . Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993; 71: 2585-2597.Direct Link:
- 14, , , et al. A prospective study on glioblastoma in the elderly. Cancer. 2003; 97: 657-662.Direct Link:
- 15, , , et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol. 2008; 88: 97-103.
- 16, . A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma. J Neurooncol. 2007; 82: 207-209.
- 17, , , et al. Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer. 2004; 100: 2208-2214.Direct Link:
- 18, , , , , . Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution. Int J Radiat Oncol Biol Phys. 1998; 42: 981-987.
- 19, , , , . Management of patients aged >60 years with malignant glioma: good clinical status and radiotherapy determine outcome. Br J Neurosurg. 2002; 16: 343-347.
- 20, , . Management of patients aged over 60 years with supratentorial glioma: lessons from an audit. Surg Neurol. 1991; 36: 106-111.
- 21, , , et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993; 85: 704-710.
- 22, , . Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis. Neuro Oncol. 2004; 6: 227-235.
- 23, , , et al. Patterns of care for adults with newly diagnosed malignant glioma. JAMA. 2005; 293: 557-564.
- 24, , , et al. Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol. 2008; 89: 97-103.
- 25, , , et al. Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients. Expert Rev Anticancer Ther. 2008; 8: 733-741.