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Dynamics and management of cytopenias associated with dasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure
Article first published online: 10 JUN 2009
DOI: 10.1002/cncr.24432
Copyright © 2009 American Cancer Society
Additional Information
How to Cite
Quintás-Cardama, A., De Souza Santos, F. P., Kantarjian, H., O'Brien, S., Faderl, S., Awais, A., Borthakur, G. and Cortes, J. (2009), Dynamics and management of cytopenias associated with dasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure. Cancer, 115: 3935–3943. doi: 10.1002/cncr.24432
Publication History
- Issue published online: 20 AUG 2009
- Article first published online: 10 JUN 2009
- Manuscript Accepted: 22 JAN 2009
- Manuscript Revised: 15 JAN 2009
- Manuscript Received: 1 OCT 2008
References
- 1, , , et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004; 47: 6658-6661.
- 2, , , et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006; 354: 2531-2541.
- 3, , , et al. Dasatinib time to and durability of major and complete cytogenetic response (MCyR and CCyR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) [abstract]. Blood. 2008; 112. Abstract 450.
- 4, , , et al. Granulocyte-colony-stimulating factor (filgrastim) may overcome imatinib-induced neutropenia in patients with chronic-phase chronic myelogenous leukemia. Cancer. 2004; 100: 2592-2597.Direct Link:
- 5, , , , , . Interleukin 11 may improve thrombocytopenia associated with imatinib mesylate therapy in chronic myelogenous leukemia. Leuk Res. 2004; 28: 613-618.
- 6, , , et al. Erythropoietin is effective in improving the anemia induced by imatinib mesylate therapy in patients with chronic myeloid leukemia in chronic phase. Cancer. 2004; 100: 2396-2402.Direct Link:
- 7, , . Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell. 2003; 112: 831-843.
- 8, , , et al. A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: a Southwest oncology group study. Blood. 1998; 91: 3607-3615.
- 9, , , et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002; 346: 645-652.
- 10, , , et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006; 355: 2408-2417.
- 11, , , et al. Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C). [abstract]. Proc Am Soc Clin Oncol. 2008; 26( May 20 suppl. Abstract 7009.
- 12, , , et al. Dasatinib dose-optimization in chronic phase chronic myeloid leukemia (CML-CP): 2-year data from CA180–034 show equivalent long-term efficacy and improved safety with 100 mg once daily dose [abstract]. Blood. 2008; 112. Abstract 3225.
- 13, , , et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996; 2: 561-566.
- 14, , , , , . Overriding imatinib resistance with a novel ABL kinase inhibitor. Science. 2004; 305: 399-401.
- 15, , , et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer. 2004; 100: 116-121.Direct Link:
- 16, , , et al. Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa. Leukemia. 2003; 17: 1448-1453.
- 17, , , , , . Granulocyte colony-stimulating factor reverses cytopenia and may permit cytogenetic responses in patients with chronic myeloid leukemia treated with imatinib mesylate. Haematologica. 2003; 88: 227-229.
- 18, , , , . Imatinib-associated neutropenia may not be overcome by filgrastim treatment in patients with blastic phase of chronic myeloid leukaemia. Clin Lab Haematol. 2006; 28: 208-210.Direct Link:
- 19, , , et al. G-CSF for imatinib-induced neutropenia. Leukemia. 2003; 17: 805-807.
- 20, , , et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007; 109: 2112-2120.
- 21. Weighing the hazards of erythropoiesis stimulation in patients with cancer. N Engl J Med. 2007; 356: 2445-2448.

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