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Original Article
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Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma†‡
Article first published online: 17 JUN 2009
DOI: 10.1002/cncr.24481
Copyright © 2009 American Cancer Society
Additional Information
How to Cite
Anderson, W. F., Pfeiffer, R. M., Tucker, M. A. and Rosenberg, P. S. (2009), Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma. Cancer, 115: 4176–4185. doi: 10.1002/cncr.24481
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We thank the reviewers for helpful comments, which improved the content of this article.
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This article is US Government work and, as such, is in the public domain in the United States of America.
Publication History
- Issue published online: 4 SEP 2009
- Article first published online: 17 JUN 2009
- Manuscript Accepted: 5 FEB 2009
- Manuscript Revised: 2 FEB 2009
- Manuscript Received: 8 DEC 2008
References
- 1, , , . Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006; 24: 4340-4346.
- 2, , , . Toward a molecular classification of melanoma. J Clin Oncol. 2007; 25: 1606-1620.
- 3, , , , . Relationship of melanoma and other skin cancer mortality to latitude and ultraviolet radiation in the United States and Canada. Int J Epidemiol. 1974; 3: 325-332.
- 4, . Malignant melanoma risk by nativity, place of residence at diagnosis, and age at migration. Cancer Causes Control. 1991; 2: 401-411.
- 5, . Melanoma and sun exposure: an overview of published studies. Int J Cancer. 1997; 73: 198-203.Direct Link:
- 6, , , , . Occupational sunlight exposure and cancer incidence among Swedish construction workers. Epidemiology. 2001; 12: 552-557.
- 7. Site-specific risk of cutaneous malignant melanoma and pattern of sun exposure in New Zealand. Int J Cancer. 2000; 85: 627-632.Direct Link:
- 8, , . Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. Am J Epidemiol. 1977; 105: 420-427.
- 9, , , , . An analysis of risk factors for cutaneous melanoma by anatomical site (Australia). Cancer Causes Control. 2005; 16: 193-199.
- 10. Is sunlight important to melanoma causation? Cancer Epidemiol Biomarkers Prev. 2008; 17: 467-468.
- 11. Effect modification and the limits of biological inference from epidemiologic data. J Clin Epidemiol. 1991; 44: 221-232.
- 12, , , , . Age-related crossover in breast cancer incidence rates between black and white ethnic groups. J Natl Cancer Inst. 2008; 100: 1804-1814.
- 13National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) Program. SEER Program, SEER*Stat Database: Incidence-SEER 9 Registries, limited-use, based on the November 2006 submission (1992-2004). Bethesda, Md: National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch; 2007. Available at: http://www.seer.cancer.gov Accessed on February 1, 2009.
- 14World Health Organization. International Classification of Diseases for Oncology. 3rd ed. US Interim Version 2000. Geneva, Switzerland: World Health Organization; 2000.
- 15, . Testing for qualitative interactions between treatment effects and patient subsets. Biometrics. 1985; 41: 361-372.
- 16, , , . Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End results database. Breast Cancer Res Treat. 2002; 76: 27-36.
- 17, , , . Comparison of age frequency distribution patterns for different histopathologic types of breast carcinoma. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1899-1905.
- 18, , , , . Combining assays for estimating prevalence of human herpes virus 8 infection using multivariate mixture models. Biostatistics. 2008; 9: 137-151.
- 19. The estimation of age, period and cohort effects for vital rates. Biometrics. 1983; 39: 311-324.
- 20. Information theory and an extension of the maximum likelihood principle. In: PetrovB, CsakiF, eds. Proceedings of the Second International Symposium on Information Theory. Budapest, Hungary: Akademiai Kiado; 1973: 267-281.
- 21. Melanocytic and nevocytic malignant melanomas. Cellular and subcellular differentiation. Cancer. 1967; 20: 632-649.Direct Link:
- 22, , , , , . Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J Natl Cancer Inst. 2003; 95: 806-812.
- 23, , , . The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res. 1969; 29: 705-727.
- 24, , , , , . The developmental biology of primary human malignant melanomas. Semin Oncol. 1975; 2: 83-103.
- 25, , , , . The classification of malignant melanoma, its histological reporting and registration: a revision of the 1972 Sydney classification. Pathology (Phila). 1986; 18: 12-21.
- 26. The classification of melanoma and its relationship with prognosis. Pathology (Phila). 1970; 2: 85-98.
- 27. Malignant melanoma: a unifying concept. Hum Pathol. 1980; 11: 591-595.
- 28, , , et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001; 19: 3635-3648.
- 29, , . p53 Expression and risk factors for cutaneous melanoma: a case-control study. Int J Cancer. 1998; 77: 843-848.Direct Link:
- 30, , , et al. Etiologic factors associated with p53 immunostaining in cutaneous malignant melanoma. Int J Cancer. 2005; 117: 486-493.Direct Link:
- 31, , , et al. Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst. 2003; 95: 1878-1890.
- 32, , , et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005; 353: 2135-2147.
- 33, , , et al. MC1R germline variants confer risk for BRAF-mutant melanoma. Science. 2006; 313: 521-522.
- 34, , , et al. Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites. Clin Cancer Res. 2004; 10: 3444-3447.
- 35, , , . Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results Program. J Invest Dermatol. 2008; 128: 243-245.

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