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Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

  1. Michelle Z. Xu MD1,
  2. Tzy-Jyun Yao PhD2,
  3. Nikki P. Y. Lee PhD1,
  4. Irene O. L. Ng MD, PhD3,
  5. Yuk-Tat Chan MBBS4,
  6. Lars Zender MD5,
  7. Scott W. Lowe PhD5,
  8. Ronnie T. P. Poon MD, PhD1,
  9. John M. Luk DrMedSc1,†,*

Article first published online: 23 JUN 2009

DOI: 10.1002/cncr.24495

Issue

Cancer

Cancer

Volume 115, Issue 19, pages 4576–4585, 1 October 2009

Additional Information

How to Cite

Xu, M. Z., Yao, T.-J., Lee, N. P. Y., Ng, I. O. L., Chan, Y.-T., Zender, L., Lowe, S. W., Poon, R. T. P. and Luk, J. M. (2009), Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer, 115: 4576–4585. doi: 10.1002/cncr.24495

Author Information

  1. 1

    Department of Surgery and Center for Cancer Research, the University of Hong Kong, Pokfulam, Hong Kong

  2. 2

    Clinical Trial Center, the University of Hong Kong, Pokfulam, Hong Kong

  3. 3

    Department of Pathology, the University of Hong Kong, Pokfulam, Hong Kong

  4. 4

    Department of Pathology and Clinical Biochemistry, Queen Mary Hospital, Pokfulam, Hong Kong

  5. 5

    Howard Hughes Medical Institute and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

  1. †

    Fax: (011) 852-28199636

*Department of Surgery, the University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China

Publication History

  1. Issue published online: 17 SEP 2009
  2. Article first published online: 23 JUN 2009
  3. Manuscript Accepted: 13 FEB 2009
  4. Manuscript Revised: 22 JAN 2009
  5. Manuscript Received: 1 DEC 2008

Funded by

  • Research Grants Council of Hong Kong. Grant Numbers: 772109M, 771607M
  • Innovation and Technology Commission of the Hong Kong Government. Grant Number: ITS120/07
  • Sun Chieh Yeh Research Foundation for Hepatobiliary and Pancreatic Surgery

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  17. 17
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