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Article first published online: 30 JUL 2009
Published 2009 American Cancer Society
Volume 115, Issue 21, pages 5060–5070, 1 November 2009
How to Cite
Moore, S. C., Peters, T. M., Ahn, J., Park, Y., Schatzkin, A., Albanes, D., Hollenbeck, A. and Leitzmann, M. F. (2009), Age-specific physical activity and prostate cancer risk among white men and black men. Cancer, 115: 5060–5070. doi: 10.1002/cncr.24538
We are indebted to the participants in the NIH-AARP Diet and Health Study for their outstanding cooperation. This work was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, and by grant TU2CA105666 (to S.C.M.). S.C.M. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Cancer incidence data from the Atlanta metropolitan area were collected by the Georgia Center for Cancer Statistics, Department of Epidemiology, Rollins School of Public Health, Emory University. Cancer incidence data from California were collected by the California Department of Health Services, Cancer Surveillance Section. Cancer incidence data from the Detroit metropolitan area were collected by the Michigan Cancer Surveillance Program, Community Health Administration, State of Michigan. The Florida cancer incidence data used in this report were collected by the Florida Cancer Data System under contract to the Department of Health (DOH). The views expressed herein are solely those of the authors and do not necessarily reflect those of the contractor or DOH. Cancer incidence data from Louisiana were collected by the Louisiana Tumor Registry, Louisiana State University Medical Center in New Orleans. Cancer incidence data from New Jersey were collected by the New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey State Department of Health and Senior Services. Cancer incidence data from North Carolina were collected by the North Carolina Central Cancer Registry. Cancer incidence data from Pennsylvania were supplied by the Division of Health Statistics and Research, Pennsylvania Department of Health, Harrisburg, Pennsylvania. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions.
This article is US Government work and, as such, is in the public domain in the United States of America.
- Issue published online: 19 OCT 2009
- Article first published online: 30 JUL 2009
- Manuscript Revised: 11 MAR 2009
- Manuscript Accepted: 4 MAR 2009
- Manuscript Received: 29 DEC 2008
- physical activity;
The relation of physical activity across the lifespan to risk of prostate cancer has not been thoroughly investigated, particularly among black men. The authors investigated physical activity, including activity during different age periods and of various intensities, in relation to prostate cancer incidence among white men and black men.
In total, 160,006 white men and 3671 black men ages 51 years to 72 years who were enrolled in the National Institutes of Health-AARP Diet and Health Study reported their time spent per week engaging in physical activity during ages 15 to 18 years, 19 years to 29 years, 35 years to 39 years, and during the past 10 years. Cox regression models were used to examine physical activity, categorized by intensity (moderate or vigorous, light, and total), in relation to prostate cancer risk.
During 7 years of follow-up, 9624 white men and 371 black men developed prostate cancer. Among white men, physical activity had no association with prostate cancer regardless of age period or activity intensity. Among black men, engaging in ≥4 hours of moderate/vigorous intensity physical activity versus infrequent activity during ages 19 years to 29 years was related to a 35% lower risk of prostate cancer (relative risk, 0.65; 95% confidence interval [95% CI], 0.43-0.99 [Ptrend = .01]). Frequent moderate/vigorous physical activity at ages 35 years to 39 years also potentially was related to reduced prostate cancer risk (relative risk, 0.59; 95% CI, 0.36-0.96 [Ptrend = .15]).
Regular physical activity may reduce prostate cancer risk among black men, and activity during young adulthood may yield the greatest benefit. This novel finding needs confirmation in additional studies. Cancer 2009. Published 2009 by the American Cancer Society.