Original Article

You have full text access to this OnlineOpen article

Obesity as a predictor of adverse outcome across black and white race†

Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database

  1. Jayakrishnan Jayachandran MD1,2,
  2. Lionel L. Bañez MD1,2,
  3. William J. Aronson MD3,4,
  4. Martha K. Terris MD5,6,
  5. Joseph C. Presti Jr. MD7,8,
  6. Christopher L. Amling MD9,10,
  7. Christopher J. Kane MD11,
  8. Stephen J. Freedland MD1,2,‡,*,
  9. the SEARCH Database Study Group

Article first published online: 10 AUG 2009

DOI: 10.1002/cncr.24571

Issue

Cancer

Cancer

Volume 115, Issue 22, pages 5263–5271, 15 November 2009

Additional Information

How to Cite

Jayachandran, J., Bañez, L. L., Aronson, W. J., Terris, M. K., Presti, J. C., Amling, C. L., Kane, C. J., Freedland, S. J. and the SEARCH Database Study Group (2009), Obesity as a predictor of adverse outcome across black and white race. Cancer, 115: 5263–5271. doi: 10.1002/cncr.24571

Author Information

  1. 1

    Division of Urologic Surgery, Departments of Surgery and Pathology, and the Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina

  2. 2

    Urology Section, Veterans Affairs Medical Center, Durham, North Carolina

  3. 3

    Urology Section, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California

  4. 4

    Department of Urology, University of California at Los Angeles School of Medicine, Los Angeles, California

  5. 5

    Urology Section, Veterans Affairs Medical Center Augusta, Georgia

  6. 6

    Section of Urology, Medical College of Georgia, Augusta, Georgia

  7. 7

    Department of Urology, Stanford University School of Medicine, Palo Alto, California

  8. 8

    Urology Section, Veterans Affairs Medical Center, Palo Alto, California

  9. 9

    Division of Urology, University of Alabama at Birmingham, Birmingham, Alabama

  10. 10

    Urology Section, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama

  11. 11

    Division of Urology, University of California, San Diego School of Medicine, San Diego, California

  1. ‡

    Fax: (919) 668-7093

*Division of Urology, Box 2626 Duke University Medical Center, Duke University School of Medicine, Durham, NC 27710

  1. †

    Views and opinions of, and endorsements by the author(s) do not reflect those of the US Army or the Department of Defense.

Publication History

  1. Issue published online: 3 NOV 2009
  2. Article first published online: 10 AUG 2009
  3. Manuscript Revised: 9 DEC 2009
  4. Manuscript Accepted: 22 JAN 2009
  5. Manuscript Received: 8 OCT 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (228K)

References

  • 1
    Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003; 348: 1625-1638.
  • 2
    Freedland SJ, Aronson WJ, Kane CJ, et al. Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital Database Study Group. J Clin Oncol. 2004; 22: 446-453.
  • 3
    Amling CL, Riffenburgh RH, Sun L, et al. Pathologic variables and recurrence rates as related to obesity and race in men with prostate cancer undergoing radical prostatectomy. J Clin Oncol. 2004; 22: 439-445.
  • 4
    Bassett WW, Cooperberg MR, Sadetsky N, et al. Impact of obesity on prostate cancer recurrence after radical prostatectomy: data from CaPSURE. Urology. 2005; 66: 1060-1065.
  • 5
    Ries LAG, Eisner MP, Kosary CL, et al. eds. SEER Cancer Statistics Review, 1975-2002. Bethesda, Md: National Cancer Institute; 2005. Available at: http://seer.cancer.gov/csr/1975_2002/ Accessed February 15, 2008.
  • 6
    Freedland SJ, Isaacs WB. Explaining racial differences in prostate cancer in the United States: sociology or biology? Prostate. 2005; 62: 243-252.
    Direct Link:
  • 7
    Freedland SJ, Amling CL, Dorey F, et al. Shared Equal Access Regional Cancer Hospital Database Study Group. Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Urology. 2002; 60: 670-674.
  • 8
    Spangler E, Zeigler-Johnson CM, Coomes M, Malkowicz SB, Wein A, Rebbeck TR. Association of obesity with tumor characteristics and treatment failure of prostate cancer in African-American and European American men. J Urol. 2007; 178: 1939-1944; discussion 1945.
  • 9
    Freedman DS, Khan LK, Serdula MK, Galuska DA, Dietz WH. Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA. 2002; 288: 1758-1761.
  • 10
    Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006; 295: 1549-1555.
  • 11
    Rodriguez C, Freedland SJ, Deka A, et al. Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev. 2007; 16: 63-69.
  • 12
    Wright ME, Chang SC, Schatzkin A, et al. Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer. 2007; 109: 675-684.
    Direct Link:
  • 13
    Gong Z, Neuhouser ML, Goodman PJ, et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1977-1983.
  • 14
    Grossfeld GD, Latini DM, Downs T, Lubeck DP, Mehta SS, Carroll PR. Is ethnicity an independent predictor of prostate cancer recurrence after radical prostatectomy? J Urol. 2002; 168: 2510-2515.
  • 15
    Nielsen ME, Han M, Mangold L, et al. Black race does not independently predict adverse outcome following radical retropubic prostatectomy at a tertiary referral center. J Urol. 2006; 176: 515-519.
  • 16
    Severi G, Morris HA, MacInnis RJ, et al. Circulating steroid hormones and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006; 15: 86-91.
  • 17
    Platz EA, Leitzmann MF, Rifai N, et al. Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era. Cancer Epidemiol Biomarkers Prev. 2005; 14: 1262-1269.
  • 18
    Chang S, Wu X, Yu H, Spitz MR. Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. Cancer Epidemiol Biomarkers Prev. 2002; 11: 758-766.
  • 19
    Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004; 363: 1346-1353.
  • 20
    Saglam K, Aydur E, Yilmaz M, Goktas S. Leptin influences cellular differentiation and progression in prostate cancer. J Urol. 2003; 169: 1308-1311.
  • 21
    Goktas S, Yilmaz MI, Caglar K, Sonmez A, Kilic S, Bedir S. Prostate cancer and adiponectin. Urology. 2005; 65: 1168-1172.
  • 22
    Freedland SJ, Humphreys EB, Mangold LA, Eisenberger M, Partin AW. Time to prostate specific antigen recurrence after radical prostatectomy and risk of prostate cancer specific mortality. J Urol. 2006; 176: 1404-1408.
View Full Article (HTML) Get PDF (228K)