Patterns of adaptation in patients living long term with advanced cancer

Authors

  • Julia Hannum Rose PhD, MA,

    Corresponding author
    1. Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
    3. Louis Stokes Cleveland Veterans Affairs Medical Center-Geriatric Research Education and Clinical Center, Cleveland, Ohio
    4. Case Comprehensive Cancer Center Program on Aging and Cancer, Cleveland, Ohio
    • Department of Medicine, Geriatrics and Palliative Care, Case Western Reserve University, 2500 MetroHealth Drive R245A, Cleveland, OH 44109
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    • Fax: (216) 778-5935

  • George Kypriotakis MA,

    1. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
    2. Louis Stokes Cleveland Veterans Affairs Medical Center-Geriatric Research Education and Clinical Center, Cleveland, Ohio
    3. Department of Sociology, Case Western Reserve University, Cleveland, Ohio
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  • Karen F. Bowman PhD,

    1. Case Comprehensive Cancer Center Program on Aging and Cancer, Cleveland, Ohio
    2. Department of Sociology, Case Western Reserve University, Cleveland, Ohio
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  • Douglas Einstadter MD, MPH,

    1. Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
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  • Elizabeth E. O'Toole MD,

    1. Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
    3. Case Comprehensive Cancer Center Program on Aging and Cancer, Cleveland, Ohio
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  • Rhoderick Mechekano PhD,

    1. Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
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  • Neal V. Dawson MD

    1. Case Western Reserve University School of Medicine, Cleveland, Ohio
    2. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio
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  • Cosponsored by the National Cancer Institute's Office of Cancer Survivorship, the Office of Cancer Survivorship of the Centers for Disease Control and Prevention, and the American Cancer Society's Behavioral Research Center.

  • Presented at the Fourth Biennial Cancer Survivorship Research Conference entitled “Cancer Survivorship Research: Mapping the New Challenges,” Atlanta, Georgia, June 18-20, 2008.

Abstract

BACKGROUND:

With improved treatment, increasing proportions of patients with advanced cancer are surviving longer with their disease: into a second year after diagnosis and beyond. These longer term survivors face continuing challenges in selecting and shifting personal life goals and goals of care over years (rather than months) of life with incurable cancer. Studies are needed to explore adaptation over time in patients who are living longer term with late-stage cancer, including anxiety, depression, and spiritual well being, which are conceptualized as indicators of psychospiritual well being in patients with advanced cancer.

METHODS:

Psychospiritual well being and adaptation were explored in a study of middle-aged and older patients with advanced cancer (N = 142) who survived into a second year after diagnosis and were assessed in interviews across 4 time points. Examining patterns of adaptation over time called for in depth analytical techniques to identify variation in key outcome trajectories. General growth mixture modeling was used to explore heterogeneity in adaptation using a multivariate parallel model of anxiety, depression. and spiritual well being.

RESULTS:

Modeling revealed 3 distinct group trajectories of psychospiritual well being and adaptation (low-worsening, moderate-improving, and high-stable). Age and education were correlated with group membership. Advanced cancer survivors who were older and had more years of education were more likely to be members of the high-stable group in psychospiritual adaptation throughout the study.

CONCLUSIONS:

The current findings suggested that psychospiritual adaptation, as measured in this study, is not uniform but is characterized by heterogeneous trajectories. The results contribute to the development of better hypotheses regarding the processes of adaptation in longer term survivors with advanced cancer and to the identification of potential subgroups at greatest risk for poor outcomes. Cancer 2009;115(18 suppl):4298–310. © 2009 American Cancer Society.

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