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The higher the decrease in the standardized uptake value of positron emission tomography after chemoradiation, the better the survival of patients with gastroesophageal adenocarcinoma

  1. Heta Javeri MD1,
  2. Lianchun Xiao MS2,
  3. Eric Rohren MD3,
  4. Jeffrey H. Lee MD4,
  5. Zhongxing Liao MD5,
  6. Wayne Hofstetter MD6,
  7. Dipen Maru MD7,
  8. Manoop S. Bhutani MD4,
  9. Stephen G. Swisher MD6,
  10. Homer Macapinlac MD3,
  11. Xuemei Wang PhD2,
  12. Jaffer A. Ajani MD1,†,*

Article first published online: 14 AUG 2009

DOI: 10.1002/cncr.24604

Issue

Cancer

Cancer

Volume 115, Issue 22, pages 5184–5192, 15 November 2009

Additional Information

How to Cite

Javeri, H., Xiao, L., Rohren, E., Lee, J. H., Liao, Z., Hofstetter, W., Maru, D., Bhutani, M. S., Swisher, S. G., Macapinlac, H., Wang, X. and Ajani, J. A. (2009), The higher the decrease in the standardized uptake value of positron emission tomography after chemoradiation, the better the survival of patients with gastroesophageal adenocarcinoma. Cancer, 115: 5184–5192. doi: 10.1002/cncr.24604

Author Information

  1. 1

    Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  2. 2

    Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  3. 3

    Department of Nuclear Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  4. 4

    Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  5. 5

    Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  6. 6

    Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  7. 7

    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas

  1. †

    Fax: (713) 745-1163

*Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030

Publication History

  1. Issue published online: 3 NOV 2009
  2. Article first published online: 14 AUG 2009
  3. Manuscript Accepted: 24 FEB 2009
  4. Manuscript Revised: 4 FEB 2009
  5. Manuscript Received: 1 OCT 2008

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Abstract

BACKGROUND:

Postchemoradiation percentage decrease in standardized uptake value (SUV) of positron emission tomography (PET) from baseline correlates with overall survival (OS) and pathologic response. Analyses of dichotomized data are commonly reported. The authors analyzed percentage SUV decrease as both dichotomized and continuous variables.

METHODS:

The authors assessed 151 consecutive patients with gastroesophageal adenocarcinoma who had chemoradiation and surgery. Baseline and postchemoradiation PET/computed tomography imaging was performed. The log-rank test and Cox proportional hazards models were used to associate percentage SUV changes and OS, and logistic regression models were used to detect the association between percentage SUV changes and pathologic response.

RESULTS:

A >52% SUV decrease (dichotomized analysis) was associated with a longer OS (log-rank test, P = .023). The univariate Cox proportional hazards model indicated that greater percentage SUV decrease (as a continuous variable) was associated with a lower risk of death (hazard ratio [HR], 0.99; P = .01). Pathologic response (≤50% residual cancer) was associated with longer OS (P = .003). Patients with chemoradiation resistance (>50% residual cancer) tended to have a higher risk of death than those with chemoradiation sensitivity (0-50% residual cancer; HR, 2.12; P = .099). In the multivariate model, the percentage SUV decrease (as a continuous variable) was the only prognosticator of OS (P = .01). The percentage SUV decrease was nonsignificantly associated with pathologic complete response (univariate odds ratio [OR], 1.01; P = .06 and multivariate OR, 1.03; P = .07).

CONCLUSIONS:

The greater the decline in SUV after chemoradiation, the longer is the OS of gastroesophageal adenocarcinoma patients. The percentage SUV decrease as a continuous variable is a better prognosticator of OS than its dichotomized assessments. Cancer 2009. © 2009 American Cancer Society.

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